每年出版 6 期
ISSN 打印: 1040-8401
ISSN 在线: 2162-6472
IF:
1.3
5-Year IF:
2.6
Eigenfactor:
0.00079
JCI:
0.24
SJR:
0.429
SNIP:
0.287
CiteScore™::
2.7
H-Index:
81
Indexed in
Therapeutic Potential of Leukemia-Derived Dendritic Cells: Preclinical and Clinical Progress
Get access
摘要
Human leukemia-derived dendritic cells show potential as tools for therapy. Leukemic cells of patients with chronic myelogenous leukemia (CML), acute myelogenous leukemia (AML), and chronic myelomonocytic leukemia (CMML) will all undergo substantial differentiation toward dendritic cells (DC) and may be used to drive autologous T cells to acquire anti-leukemic cytotoxicity. This article describes the use of these human leukemia-derived dendritic cells for stimulation of allogeneic donor lymphocytes and presents a clinical trial of autologous CML DC-stimulated lymphocytes.
-
Kufner S., Zitzelsberger H., Kroell T., Pelka-Fleischer R., Salem A., de Valle F., Schmid C., Schweiger C., Kolb H. J., Schmetzer H. M., Leukaemia-Derived Dendritic Cells Can Be Generated From Blood or Bone Marrow Cells From Patients With Myelodysplasia: A Methodological Approach Under Serum-Free Culture Conditions, Scandinavian Journal of Immunology, 62, 1, 2005. Crossref
-
Kankuri Esko, Babusikova Olga, Hlubinova Kristina, Salmenperä Pertteli, Boccaccio Carla, Lubitz Werner, Harjula Ari, Bizik Jozef, Fibroblast nemosis arrests growth and induces differentiation of human leukemia cells, International Journal of Cancer, 122, 6, 2008. Crossref
-
Kufner S., Zitzelsberger H., Kroell T., Pelka-Fleischer R., Salem A., de Valle F., Schweiger C., Nuessler V., Schmid C., Kolb H. J., Schmetzer H. M., Leukemia-Derived Dendritic Cells can be Generated from Blood or Bone Marrow Cells from Patients with Acute Myeloid Leukaemia: A Methodological Approach under Serum-Free Culture Conditions, Scandinavian Journal of Immunology, 62, 1, 2005. Crossref
-
Yannelli John R., Sturgill Jamie, Foody Terry, Hirschowitz Edward, The large scale generation of dendritic cells for the immunization of patients with non-small cell lung cancer (NSCLC), Lung Cancer, 47, 3, 2005. Crossref
-
Costello Régis T, Fauriat Cyril, Rey Jérôme, Gastaut Jean-Albert, Olive Daniel, Immunobiology of haematological malignant disorders: the basis for novel immunotherapy protocols, The Lancet Oncology, 5, 1, 2004. Crossref
-
Kufner S., Fleischer R. Pelka, Kroell T., Schmid C., Zitzelsberger H., Salih H., Valle F. de, Treder W., Schmetzer H. M., Serum-free generation and quantification of functionally active Leukemia-derived DC is possible from malignant blasts in acute myeloid leukemia and myelodysplastic syndromes, Cancer Immunology, Immunotherapy, 54, 10, 2005. Crossref
-
Grabrucker Christine, Liepert Anja, Dreyig Julia, Kremser Andreas, Kroell Tanja, Freudenreich Markus, Schmid Christoph, Schweiger Cornelia, Tischer Johanna, Kolb Hans-Jochen, Schmetzer Helga, The Quality and Quantity of Leukemia-derived Dendritic Cells From Patients With Acute Myeloid Leukemia and Myelodysplastic Syndrome Are a Predictive Factor for the Lytic Potential of Dendritic Cells-primed Leukemia-Specific T Cells, Journal of Immunotherapy, 33, 5, 2010. Crossref
-
Schwartz Joseph, Pinilla-Ibarz Javier, Yuan Rui Rong, Scheinberg David A., Novel targeted and immunotherapeutic strategies in chronic myeloid leukemia, Seminars in Hematology, 40, 1, 2003. Crossref
-
Liepert Anja, Grabrucker Christine, Kremser Andreas, Dreyßig Julia, Ansprenger Christian, Freudenreich Markus, Kroell Tanja, Reibke Roland, Tischer Johanna, Schweiger Cornelia, Schmid Christoph, Kolb Hans-Jochem, Schmetzer Helga, Quality of T-cells after stimulation with leukemia-derived dendritic cells (DC) from patients with acute myeloid leukemia (AML) or myeloid dysplastic syndrome (MDS) is predictive for their leukemia cytotoxic potential, Cellular Immunology, 265, 1, 2010. Crossref
-
Büchler Tomas, Michalek Jaroslav, Kovarova Lucie, Musilova Romana, Hajek Roman, Dendritic Cell-based Immunotherapy for the Treatment of Hematological Malignancies, Hematology, 8, 2, 2003. Crossref
-
Fischbacher Dorothea, Merle Marion, Liepert Anja, Grabrucker Christine, Kroell Tanja, Kremser Andreas, Dreyßig Julia, Freudenreich Markus, Schuster Friedhelm, Borkhardt Arndt, Kraemer Doris, Koehne Claus-Henning, Kolb Hans-Jochem, Schmid Christoph, Schmetzer Helga Maria, Cytokine Release Patterns in Mixed Lymphocyte Culture (MLC) of T-Cells with Dendritic Cells (DC) Generated from AML Blasts Contribute to Predict anti-Leukaemic T-Cell Reactions and Patients’ Response to Immunotherapy, Cell Communication & Adhesion, 22, 2-6, 2015. Crossref
-
Moldenhauer Anja, Frank Richard C., Pinilla-Ibarz Javier, Holland Gudrun, Boccuni Piernicola, Scheinberg David A., Salama Abdulgabar, Seeger Karl, Moore Malcolm A. S., Nimer Stephen D., Histone deacetylase inhibition improves dendritic cell differentiation of leukemic blasts with AML1-containing fusion proteins, Journal of Leukocyte Biology, 76, 3, 2004. Crossref
-
Yi Qing, Vaccines for Hematological Malignancies, in Handbook of Cancer Vaccines, 2004. Crossref
-
Gabriele Lucia, Borghi Paola, Rozera Carmela, Sestili Paola, Andreotti Mauro, Guarini Anna, Montefusco Enrico, Foà Robert, Belardelli Filippo, IFN-α promotes the rapid differentiation of monocytes from patients with chronic myeloid leukemia into activated dendritic cells tuned to undergo full maturation after LPS treatment, Blood, 103, 3, 2004. Crossref
-
Shi Yin, Zhang Zhen, Qu Xintao, Zhu Xiaoxiao, Zhao Lin, Wei Ran, Guo Qiang, Sun Linlin, Yin Xunqiang, Zhang Yunhong, Li Xia, Roles of STAT3 in leukemia (Review), International Journal of Oncology, 2018. Crossref
-
Moldenhauer Anja, Moore Malcolm A.S., Schmidt Kerstin, Kiesewetter Holger, Salama Abdulgabar, Differences in the transmigration of different dendritic cells, Experimental Hematology, 34, 6, 2006. Crossref
-
Salesse Stephanie, Verfaillie Catherine M, BCR/ABL: from molecular mechanisms of leukemia induction to treatment of chronic myelogenous leukemia, Oncogene, 21, 56, 2002. Crossref