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The Impact Factor measures the average number of citations received in a particular year by papers published in the journal during the two preceding years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) IF: 1.3 To calculate the five year Impact Factor, citations are counted in 2017 to the previous five years and divided by the source items published in the previous five years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) 5-Year IF: 2.6 The Eigenfactor score, developed by Jevin West and Carl Bergstrom at the University of Washington, is a rating of the total importance of a scientific journal. Journals are rated according to the number of incoming citations, with citations from highly ranked journals weighted to make a larger contribution to the eigenfactor than those from poorly ranked journals. Eigenfactor: 0.00079 The Journal Citation Indicator (JCI) is a single measurement of the field-normalized citation impact of journals in the Web of Science Core Collection across disciplines. The key words here are that the metric is normalized and cross-disciplinary. JCI: 0.24 SJR: 0.429 SNIP: 0.287 CiteScore™:: 2.7 H-Index: 81

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Natural IgM and the Development of B Cell-Mediated Autoimmune Diseases

卷 36, 册 2, 2016, pp. 163-177
DOI: 10.1615/CritRevImmunol.2016018175
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摘要

Most serum immunoglobulin M (IgM) is "natural IgM", which is produced apparently spontaneously by a distinct subset of B cells requiring no exogenous antigenic or microbial stimuli. Natural IgM is an evolutionarily conserved molecule and reacts with a variety of epitopes expressed on both self- and non-self antigens. It has long been understood that secreted (s) IgM contributes to the removal of altered self-antigens, such as apoptotic and dying cells. As we outline in this review, it is thought that this sIgM housekeeping function removes potential triggers of autoresponse induction. However, we recently demonstrated an unexpected and distinct role for sIgM in the control of autoreactive B cells: the regulation of bone marrow B cell development. The absence of sIgM blocked pro- to pre- B-cell transition and greatly altered the BCR repertoire of the developing B cells and the peripheral B-cell pools in genetically engineered mice. This finding strongly suggests that IgM is critical for B-cell central tolerance induction. Given that treatment of sIgM-deficient mice with polyclonal IgM corrected these developmental defects, therapeutic application of IgM could be of clinical relevance in the treatment of some B-cell−mediated autoimmune diseases.

对本文的引用
  1. Dufaud Chad, Rivera Johanna, Rohatgi Soma, Pirofski Liise-anne, Naïve B cells reduce fungal dissemination in Cryptococcus neoformans infected Rag1−/− mice, Virulence, 9, 1, 2018. Crossref

  2. Gupta Sudhir, Gupta Ankmalika, Selective IgM Deficiency—An Underestimated Primary Immunodeficiency, Frontiers in Immunology, 8, 2017. Crossref

  3. Seeling Michaela, Brückner Christin, Nimmerjahn Falk, Differential antibody glycosylation in autoimmunity: sweet biomarker or modulator of disease activity?, Nature Reviews Rheumatology, 13, 10, 2017. Crossref

  4. Grywalska Ewelina, Smarz-Widelska Iwona, Krasowska-Zajac Ewelina, Korona-Glowniak Izabela, Zaluska-Patel Karolina, Mielnik Michal, Podgajna Martyna, Malm Anna, Rolinski Jacek, Zaluska Wojciech, The PD-1/PD-L1 Inhibitory Pathway is Altered in Primary Glomerulonephritides, Archivum Immunologiae et Therapiae Experimentalis, 66, 2, 2018. Crossref

  5. Ehrenreich Hannelore, Autoantibodies against the N-Methyl-d-Aspartate Receptor Subunit NR1: Untangling Apparent Inconsistencies for Clinical Practice, Frontiers in Immunology, 8, 2017. Crossref

  6. Geier Christoph B., Sauerwein Kai M. T., Leiss-Piller Alexander, Zmek Isabella, Fischer Michael B., Eibl Martha M., Wolf Hermann M., Hypomorphic Mutations in the BCR Signalosome Lead to Selective Immunoglobulin M Deficiency and Impaired B-cell Homeostasis, Frontiers in Immunology, 9, 2018. Crossref

  7. Srdic-Rajic Tatjana, Kohler Heinz, Jurisic Vladimir, Metlas Radmila, Antibody Epitope Specificity for dsDNA Phosphate Backbone Is an Intrinsic Property of the Heavy Chain Variable Germline Gene Segment Used, Frontiers in Immunology, 9, 2018. Crossref

  8. Pan Hong, Oliveira Bárbara, Saher Gesine, Dere Ekrem, Tapken Daniel, Mitjans Marina, Seidel Jan, Wesolowski Janina, Wakhloo Debia, Klein-Schmidt Christina, Ronnenberg Anja, Schwabe Kerstin, Trippe Ralf, Mätz-Rensing Kerstin, Berghoff Stefan, Al-Krinawe Yazeed, Martens Henrik, Begemann Martin, Stöcker Winfried, Kaup Franz-Josef, Mischke Reinhard, Boretius Susann, Nave Klaus-Armin, Krauss Joachim K., Hollmann Michael, Lühder Fred, Ehrenreich Hannelore, Uncoupling the widespread occurrence of anti-NMDAR1 autoantibodies from neuropsychiatric disease in a novel autoimmune model, Molecular Psychiatry, 24, 10, 2019. Crossref

  9. Setz Corinna S., Hug Eva, Khadour Ahmad, Abdelrasoul Hend, Bilal Mayas, Hobeika Elias, Jumaa Hassan, PI3K-Mediated Blimp-1 Activation Controls B Cell Selection and Homeostasis, Cell Reports, 24, 2, 2018. Crossref

  10. Ehrenreich Hannelore, Autoantibodies against N-methyl-d-aspartate receptor 1 in health and disease, Current Opinion in Neurology, 31, 3, 2018. Crossref

  11. Platt Jeffrey L., Garcia de Mattos Barbosa Mayara, Cascalho Marilia, The five dimensions of B cell tolerance, Immunological Reviews, 292, 1, 2019. Crossref

  12. Morris Gerwyn, Puri Basant K., Olive Lisa, Carvalho Andre F., Berk Michael, Maes Michael, Emerging role of innate B1 cells in the pathophysiology of autoimmune and neuroimmune diseases: Association with inflammation, oxidative and nitrosative stress and autoimmune responses, Pharmacological Research, 148, 2019. Crossref

  13. Koulouri Vasiliki, Koutsilieris Michael, Mavragani Clio P., B cells and atherosclerosis in systemic lupus erythematosus, Expert Review of Clinical Immunology, 15, 4, 2019. Crossref

  14. Grywalska Ewelina, Smarz-Widelska Iwona, Mertowski Sebastian, Gosik Krzysztof, Mielnik Michał, Podgajna Martyna, Abramiuk Monika, Drop Bartłomiej, Roliński Jacek, Załuska Wojciech, CTLA-4 Expression Inversely Correlates with Kidney Function and Serum Immunoglobulin Concentration in Patients with Primary Glomerulonephritides, Archivum Immunologiae et Therapiae Experimentalis, 67, 5, 2019. Crossref

  15. Blandino Rebecca, Baumgarth Nicole, Secreted IgM: New tricks for an old molecule, Journal of Leukocyte Biology, 106, 5, 2019. Crossref

  16. Kurtenkov Oleg, Profiling of Naturally Occurring Antibodies to the Thomsen-Friedenreich Antigen in Health and Cancer: The Diversity and Clinical Potential, BioMed Research International, 2020, 2020. Crossref

  17. Matsuda Yoshiko, Hiramitsu Takahisa, Li Xiao-kang, Watanabe Takeshi, Characteristics of Immunoglobulin M Type Antibodies of Different Origins from the Immunologic and Clinical Viewpoints and Their Application in Controlling Antibody-Mediated Allograft Rejection, Pathogens, 10, 1, 2020. Crossref

  18. Sangesland Maya, Yousif Ashraf S., Ronsard Larance, Kazer Samuel W., Zhu Alex Lee, Gatter G. James, Hayward Matthew R., Barnes Ralston M., Quirindongo-Crespo Maricel, Rohrer Daniel, Lonberg Nils, Kwon Douglas, Shalek Alex K., Lingwood Daniel, A Single Human VH-gene Allows for a Broad-Spectrum Antibody Response Targeting Bacterial Lipopolysaccharides in the Blood, Cell Reports, 32, 8, 2020. Crossref

  19. Jani Peter K, Kubagawa Hiromi, Melchers Fritz, A rheostat sets B-cell receptor repertoire selection to distinguish self from non-self, Current Opinion in Immunology, 67, 2020. Crossref

  20. Olson Caroline G., Olson Nancy Y., Mansour Ahmad, Hyper IgG4-Related Disease Presenting with Orbital Tumor and Immune Deficiency, Case Reports in Immunology, 2021, 2021. Crossref

  21. Webb Nicholas E, Bernshtein Biana, Alter Galit, Tissues: the unexplored frontier of antibody mediated immunity, Current Opinion in Virology, 47, 2021. Crossref

  22. Matsuda Yoshiko, Watanabe Takeshi, Li Xiao-Kang, Approaches for Controlling Antibody-Mediated Allograft Rejection Through Targeting B Cells, Frontiers in Immunology, 12, 2021. Crossref

  23. Böröcz K, Simon D, Erdő-Bonyár S, Kovács K T, Tuba É, Czirják L, Németh P, Berki T, Relationship between natural and infection-induced antibodies in systemic autoimmune diseases (SAD): SLE, SSc and RA, Clinical and Experimental Immunology, 203, 1, 2020. Crossref

  24. Petkau Georg, Turner Martin, Signalling circuits that direct early B-cell development, Biochemical Journal, 476, 5, 2019. Crossref

  25. Werner Anja, Schäfer Simon, Zaytseva Olga, Albert Heike, Lux Anja, Krištić Jasminka, Pezer Marija, Lauc Gordan, Winkler Thomas, Nimmerjahn Falk, Targeting B cells in the pre-phase of systemic autoimmunity globally interferes with autoimmune pathology, iScience, 24, 9, 2021. Crossref

  26. Alipour Razieh, Sereshki Nasrin, Rafiee Mitra, Mofid Mohammad Reza, Alsahebfosoul Fereshteh, Pourazar Abbasali, Blood IgMs from healthy donors and patients with systemic lupus erythematosus reduce the inflammatory properties of platelets from healthy donors, Immunobiology, 227, 3, 2022. Crossref

  27. Zhang Wei, Wang Yong-Fu, Hu Fan-Lei, Lu Fu-Ai, Wu Tao, Feng Yue-Lan, Li Ke, Dysfunction of CD27+IgD+ B cells correlates with aggravated systemic lupus erythematosus, Clinical Rheumatology, 41, 5, 2022. Crossref

  28. Halperin Saar T., ’t Hart Bert A., Luchicchi Antonio, Schenk Geert J., The Forgotten Brother: The Innate-like B1 Cell in Multiple Sclerosis, Biomedicines, 10, 3, 2022. Crossref

  29. Ma Fengge, Zhan Yating, Bartolomé-Cabrero Rocío, Ying Wei, Asano Masahide, Huang Zhe, Xiao Changchun, González-Martín Alicia, Analysis of a miR-148a Targetome in B Cell Central Tolerance, Frontiers in Immunology, 13, 2022. Crossref

  30. Lymberi Peggy, Zannikou Markella, Hatzioannou Aikaterini, Natural Autoantibodies in Health and Disease, in Comprehensive Pharmacology, 2022. Crossref

  31. Paluri Sesha L., Burak Matthew, Senejani Alireza G., Levinson Madison, Rahim Tania, Clairmont Kaylyn, Kashgarian Michael, Alvarado-Cruz Isabel, Meas Rithy, Cardó-Vila Marina, Zeiss Caroline, Maher Stephen, Bothwell Alfred L.M., Coskun Erdem, Kant Melis, Jaruga Pawel, Dizdaroglu Miral, Stephen Lloyd R., Sweasy Joann B., DNA glycosylase deficiency leads to decreased severity of lupus in the Polb-Y265C mouse model, DNA Repair, 105, 2021. Crossref

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