图书馆订阅: Guest
Begell Digital Portal Begell 数字图书馆 电子图书 期刊 参考文献及会议录 研究收集
免疫学评论综述™
影响因子: 1.404 5年影响因子: 3.347 SJR: 0.706 SNIP: 0.55 CiteScore™: 2.19

ISSN 打印: 1040-8401
ISSN 在线: 2162-6472

免疫学评论综述™

DOI: 10.1615/CritRevImmunol.2018026790
pages 379-401

Immunomodulatory Bonds of the Partnership between Dendritic Cells and T Cells

Jessica Bourque
Department of Molecular Microbiology and Immunology, St. Louis University School of Medicine, St. Louis, MO, USA
Daniel Hawiger
Department of Molecular Microbiology and Immunology, St. Louis University School of Medicine, St. Louis, MO, USA

ABSTRACT

By acquiring, processing, and presenting both foreign and self-antigens, dendritic cells (DCs) initiate T cell activation that is shaped through the immunomodulatory functions of a variety of cell-membrane-bound molecules including BTLA-HVEM, CD40-CD40L, CTLA-4-CD80/CD86, CD70-CD27, ICOS-ICOS-L, OX40-OX40L, and PD-L1-PD-1, as well as several key cytokines and enzymes such as interleukin-6 (IL-6), IL-12, IL-23, IL-27, transforming growth factor-beta 1 (TGF-β1), retinaldehyde dehydrogenase (Raldh), and indoleamine 2,3-dioxygenase (IDO). Some of these distinct immunomodulatory signals are mediated by specific subsets of DCs, therefore contributing to the functional specialization of DCs in the priming and regulation of immune responses. In addition to responding to the DC-mediated signals, T cells can reciprocally modulate the immunomodulatory capacities of DCs, further refining immune responses. Here, we review recent studies, particularly in experimental mouse systems, that have delineated the integrated mechanisms of crucial immunomodulatory pathways that enable specific populations of DCs and T cells to work intimately together as single functional units that are indispensable for the maintenance of immune homeostasis.


Articles with similar content:

Functions of IL-4 and Control of Its Expression
Critical Reviews™ in Immunology, Vol.17, 1997, issue 1
Melissa A. Brown , John Hural
Functions of IL-4 and Control of Its Expression
Critical Reviews™ in Immunology, Vol.37, 2017, issue 2-6
Melissa A. Brown , John Hural
Inhibitory Receptor-Mediated Regulation of Natural Killer Cells
Critical Reviews™ in Immunology, Vol.34, 2014, issue 6
Beena Jeevan-Raj , Camille Grandclement, Werner Held, Elisenda Alari-Pahissa
Involvement of Yin Yang 1 (YY1) Expression in T-Cell Subsets Differentiation and Their Functions: Implications in T Cell-Mediated Diseases
Critical Reviews™ in Immunology, Vol.39, 2019, issue 6
Feodora Roxanne Kosasih, Benjamin Bonavida
Interleukin 21: A Key Player in Lymphocyte Maturation
Critical Reviews™ in Immunology, Vol.24, 2004, issue 4
Jason Brady, Mark J. Smyth, Stephen L. Nutt, Yoshihiro Hayakawa