图书馆订阅: Guest
Begell Digital Portal Begell 数字图书馆 电子图书 期刊 参考文献及会议录 研究收集
免疫学评论综述™
影响因子: 1.404 5年影响因子: 3.347 SJR: 0.706 SNIP: 0.55 CiteScore™: 2.19

ISSN 打印: 1040-8401
ISSN 在线: 2162-6472

免疫学评论综述™

DOI: 10.1615/CritRevImmunol.v23.i56.20
32 pages

Shigellosis: Innate Mechanisms of Inflammatory Destruction of the Intestinal Epithelium, Adaptive Immune Response, and Vaccine Development

Armelle Phalipon
Unite de Pathogenie Microbienne Moleculaire, INSERM U389, Institut Pasteur, 28 Rue du Dr Roux, 75015 Paris, France
P. J. Sansonetti
Unite de Pathogenie Microbienne Moleculaire, INSERM U389, Institut Pasteur, 28 Rue du Dr Roux, 75015 Paris, France

ABSTRACT

Acute infectious colitis remains a major pediatric issue of worldwide impact because it still represents a significant public health burden among the larger group of diarrheal diseases with the highest mortality rate. It is also a relevant model of inflammatory bowel diseases (IBD), such as Crohn’s disease and ulcerative colitis. Among cases of acute colitis of infectious origin, shigellosis is certainly the one that has benefited the most from a significant research effort. Shigella, the causative agent, is a Gram-negative bacterium that has the capacity to invade, disrupt, and cause inflammatory destruction of the intestinal epithelial barrier. The molecular and cellular bases of this invasive phenotype essentially encompass crossing of the epithelial lining, apoptotic killing of macrophages, entry into epithelial cells, and escape into the cytoplasm, followed by cell-to-cell spread. Intracellular colonization is likely to protect the micro-organisms from killing by humoral and cellular effectors of the innate immune response. Concurrently, the capacity of Shigella to reprogram invaded epithelial cells to produce proinflammatory mediators plays a major role in the strong inflammatory profile of the disease. This profile is likely to impact on the nature and quality of the adaptive response, which is dominated by humoral protection at the mucosal level.


Articles with similar content:

The Goldilocks Conundrum: NLR Inflammasome Modulation of Gastrointestinal Inflammation during Inflammatory Bowel Disease
Critical Reviews™ in Immunology, Vol.36, 2016, issue 4
Veronica M. Ringel-Scaia, Irving C. Allen, Dylan K. McDaniel
Regulation of NK Cell Repertoire and Function in the Liver
Critical Reviews™ in Immunology, Vol.31, 2011, issue 1
Peter D. Krueger, Huihong Qiao, Matthew G. Lassen, Young S. Hahn
Induction of Cytokines and Chemokines by Toll-like Receptor Signaling: Strategies for Control of Infammation
Critical Reviews™ in Immunology, Vol.30, 2010, issue 1
Goutam Gupta, Ahmet Zeytun, Anu Chaudhary, Paige Pardington, R. Bruce Cary
IL-21 Is an Immune Activator That also Mediates Suppression via IL-10
Critical Reviews™ in Immunology, Vol.30, 2010, issue 6
Warren J. Leonard, Rosanne Spolski
The Contribution of Thymic Stromal Abnormalities to Autoimmune Disease
Critical Reviews™ in Immunology, Vol.31, 2011, issue 3
Melanie N. Hince, Adrienne Calder, Anne L. Fletcher, Ann P. Chidgey, Richard L. Boyd