图书馆订阅: Guest
Begell Digital Portal Begell 数字图书馆 电子图书 期刊 参考文献及会议录 研究收集
免疫学评论综述™
影响因子: 1.352 5年影响因子: 3.347 SJR: 1.022 SNIP: 0.55 CiteScore™: 2.19

ISSN 打印: 1040-8401
ISSN 在线: 2162-6472

免疫学评论综述™

DOI: 10.1615/CritRevImmunol.2015012327
pages 15-31

The Ezrin-Radixin-Moesin Family of Proteins in the Regulation of B-Cell Immune Response

Debasis Pore
Department of Immunology, Lerner Research Institute, Cleveland Clinic, Cleveland, OH
Neetu Gupta
Department of Immunology, Lerner Research Institute, Cleveland Clinic, Cleveland, OH

ABSTRACT

Dynamic reorganization of the cortical cytoskeleton is essential for numerous cellular processes, including B- and T-cell activation and migration. The ezrin-radixin-moesin (ERM) family of proteins plays structural and regulatory roles in the rearrangement of plasma membrane flexibility and protrusions through its members' reversible interaction with cortical actin filaments and the plasma membrane. Recent studies demonstrated that ERM proteins not only are involved in cytoskeletal organization but also offer a platform for the transmission of signals in response to a variety of extracellular stimuli through their ability to cross-link transmembrane receptors with downstream signaling components. In this review, we summarize present knowledge relating to ERMs and recent progress made toward elucidating a novel role for them in the regulation of B-cell function in health and disease.


Articles with similar content:

Antigen-Specific B-Lymphocyte Activation
Critical Reviews™ in Immunology, Vol.23, 2003, issue 3
Gail A. Bishop, Sokol A. Haxhinasto, Bruce S. Hostager, Laura L. Stunz
Mechanisms of Calcium Signaling and Function in Lymphocytes
Critical Reviews™ in Immunology, Vol.26, 2006, issue 2
Bruce D. Freedman
Mechanical Cues for T Cell Activation: Role of Piezo1 Mechanosensors
Critical Reviews™ in Immunology, Vol.39, 2019, issue 1
Dipyaman Ganguly, Chinky Shiu Chen Liu
Immunomodulatory Bonds of the Partnership between Dendritic Cells and T Cells
Critical Reviews™ in Immunology, Vol.38, 2018, issue 5
Jessica Bourque, Daniel Hawiger
Post-Translational Processing of Proopiomelanocortin in the Pituitary and in the Brain
Critical Reviews™ in Neurobiology, Vol.11, 1997, issue 1
Ewan Morrison, Maria G. Castro