图书馆订阅: Guest
Begell Digital Portal Begell 数字图书馆 电子图书 期刊 参考文献及会议录 研究收集
免疫学评论综述™
影响因子: 1.352 5年影响因子: 3.347 SJR: 0.657 SNIP: 0.55 CiteScore™: 2.19

ISSN 打印: 1040-8401
ISSN 在线: 2162-6472

免疫学评论综述™

DOI: 10.1615/CritRevImmunol.2013006858
pages 435-476

MicroRNA Regulation of T-Lymphocyte Immunity: Modulation of Molecular Networks Responsible for T-Cell Activation, Differentiation, and Development

Katie Podshivalova
Laboratory for Functional Genomics, Department of Molecular and Experimental Medicine, The Scripps Research Institute, La Jolla, CA
Daniel R. Salomon
Laboratory for Functional Genomics, Department of Molecular and Experimental Medicine, The Scripps Research Institute, La Jolla, CA

ABSTRACT

MicroRNAs (miRNA) are a class of small non-coding RNAs that constitute an essential and evolutionarily conserved mechanism for post-transcriptional gene regulation. Multiple miRNAs have been described to play key roles in T-lymphocyte development, differentiation, and function. In this review, we highlight the current literature regarding the differential expression of miRNAs in various models of murine and human T-cell biology. We emphasize mechanistic understandings of miRNA regulation of thymocyte development, T-cell activation, and differentiation into effector and memory subsets. We describe the participation of miRNAs in complex regulatory circuits shaping T-cell proteomes in a context-dependent manner. It is striking that some miRNAs regulate multiple processes, while others only appear in limited functional contexts. It is also evident that the expression and function of specific miRNAs can differ between murine and human systems. Ultimately, it is not always correct to simplify the complex events of T-cell biology into a model driven by only one or two master regulator miRNAs. In reality, T-cell activation and differentiation involve the expression of multiple miRNAs with many mRNA targets; thus, the true extent of miRNA regulation of T-cell biology is likely far more vast than currently appreciated.


Articles with similar content:

Drugs That Target Gene Expression: An Overview
Critical Reviews™ in Eukaryotic Gene Expression, Vol.6, 1996, issue 1
Filippo Cavalieri
Multifaceted Modulation of SIRT1 in Cancer and Inflammation
Critical Reviews™ in Oncogenesis, Vol.20, 2015, issue 1-2
Yun Lu, Xi Chen, Guangwei Liu, Hui Yang, Yujing Bi, Zhengguo Zhang, Yiwei Chu, Jian Wang, Ruifu Yang, Ruoning Wang, Lixiang Xue
The Roles of Chromatin Remodeling Genes in Pancreatic-Biliary Malignancies
Critical Reviews™ in Oncogenesis, Vol.22, 2017, issue 5-6
Claudio Luchini, Alessia Nottegar
Tumor Necrosis Factor-α Signaling in Macrophages
Critical Reviews™ in Eukaryotic Gene Expression, Vol.20, 2010, issue 2
Sonika Patial, Narayanan Parameswaran
mTOR Regulates T-Cell Differentiation and Activation in Immunity and Autoimmunity
Critical Reviews™ in Eukaryotic Gene Expression, Vol.21, 2011, issue 4
Guangwei Liu, Yujing Bi, Ruifu Yang