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ISSN 打印: 1040-8401

ISSN 在线: 2162-6472

The Impact Factor measures the average number of citations received in a particular year by papers published in the journal during the two preceding years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) IF: 1.3 To calculate the five year Impact Factor, citations are counted in 2017 to the previous five years and divided by the source items published in the previous five years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) 5-Year IF: 2.6 The Eigenfactor score, developed by Jevin West and Carl Bergstrom at the University of Washington, is a rating of the total importance of a scientific journal. Journals are rated according to the number of incoming citations, with citations from highly ranked journals weighted to make a larger contribution to the eigenfactor than those from poorly ranked journals. Eigenfactor: 0.00079 The Journal Citation Indicator (JCI) is a single measurement of the field-normalized citation impact of journals in the Web of Science Core Collection across disciplines. The key words here are that the metric is normalized and cross-disciplinary. JCI: 0.24 SJR: 0.429 SNIP: 0.287 CiteScore™:: 2.7 H-Index: 81

Indexed in

Generation of Human γδ T-Cell Repertoires

卷 19, 册 5-6, 1999, 30 pages
DOI: 10.1615/CritRevImmunol.v19.i5-6.30
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摘要

The nature of how the human γδ T-cell repertoire is generated during normal development is poorly understood. Unlike TCR -αβ+ cells that are almost exclusively dependent upon the thymus for their development and maturation, γδ T cells can be generated in extrathymic sites. The focus of this article is to understand how the human γδ T-cell repertoire is generated during normal human development before and after birth. The expressed repertoire is a reflection of many mechanisms operating at both the DNA and protein levels, and we describe the features of the observed repertoires in various tissues in fetal and postnatal development and in the adult, and the potential mechanisms that account for them. Identifying the site(s) of origin and understanding how the various subsets of γδ T cells are generated is important for understanding their function. In addition, understanding how the γδ T-cell repertoire is modulated during life by infection, inflammation, and cancer should also bring us closer to understanding its function.

对本文的引用
  1. Goldman Armond S., Goldman Lynn R., Goldman Daniel A., What Caused the Epidemic of Pneumocystis Pneumonia in European Premature Infants in the Mid-20th Century?, Pediatrics, 115, 6, 2005. Crossref

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