图书馆订阅: Guest
免疫学评论综述™

每年出版 6 

ISSN 打印: 1040-8401

ISSN 在线: 2162-6472

The Impact Factor measures the average number of citations received in a particular year by papers published in the journal during the two preceding years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) IF: 1.3 To calculate the five year Impact Factor, citations are counted in 2017 to the previous five years and divided by the source items published in the previous five years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) 5-Year IF: 2.6 The Eigenfactor score, developed by Jevin West and Carl Bergstrom at the University of Washington, is a rating of the total importance of a scientific journal. Journals are rated according to the number of incoming citations, with citations from highly ranked journals weighted to make a larger contribution to the eigenfactor than those from poorly ranked journals. Eigenfactor: 0.00079 The Journal Citation Indicator (JCI) is a single measurement of the field-normalized citation impact of journals in the Web of Science Core Collection across disciplines. The key words here are that the metric is normalized and cross-disciplinary. JCI: 0.24 SJR: 0.429 SNIP: 0.287 CiteScore™:: 2.7 H-Index: 81

Indexed in

The Caspase-8 Modulator c-FLIP

卷 25, 册 1, 2005, pp. 31-58
DOI: 10.1615/CritRevImmunol.v25.i1.30
Get accessGet access

摘要

Death receptors belong to the tumor necrosis factor receptor superfamily and can induce apoptosis through activation of procaspase-8. The cellular FLICE-inhibitory protein (c-FLIP) is able to modulate activation of procaspase-8 and thereby prevents induction of apoptosis mediated by death receptors. As an important modulator of caspase-8, c-FLIP regulates life and death in various types of normal cells and tissues, such as lymphoid cells, and renders resistance to death receptor-mediated apoptosis in many types of cancer cells. In addition to an apoptosis modulator, c-FLIP has been shown to exert other physiological functions related to cell proliferation and tumorigenesis. Dysregulation of c-FLIP expression has been shown to be associated with various diseases, such as cancer and autoimmune diseases, and c-FLIP might be a critical target for therapeutic intervention. This review focuses on recent findings about the physiological function and intracellular regulation of c-FLIP.

对本文的引用
  1. van Houdt I S, Muris J J, Hesselink A T, Kramer D, Cillessen S A G M, Moesbergen L M, Vos W, Hooijberg E, Meijer C J L M, Kummer J A, Oudejans J J, Expression of c-FLIP is primarily detected in diffuse large B-cell lymphoma and Hodgkin’s lymphoma and correlates with lack of caspase 8 activation, Histopathology, 51, 6, 2007. Crossref

  2. Kataoka Takao, Chemical biology of inflammatory cytokine signaling, The Journal of Antibiotics, 62, 12, 2009. Crossref

  3. Clemo Nadine K., Collard Tracey J., Southern Samantha L., Edwards Kieron D., Moorghen Moganaden, Packham Graham, Hague Angela, Paraskeva Christos, Williams Ann C., BAG-1 is up-regulated in colorectal tumour progression and promotes colorectal tumour cell survival through increased NF-κB activity, Carcinogenesis, 29, 4, 2008. Crossref

  4. Ueffing Nana, Schuster Marc, Keil Eric, Schulze-Osthoff Klaus, Schmitz Ingo, Up-regulation of c-FLIPshort by NFAT contributes to apoptosis resistance of short-term activated T cells, Blood, 112, 3, 2008. Crossref

  5. Silbermann Katrin, Grassmann Ralph, Human T cell leukemia virus type 1 Tax-induced signals in cell survival, proliferation, and transformation, Signal Transduction, 7, 1, 2007. Crossref

  6. Bijangi-Vishehsaraei Khadijeh, Saadatzadeh Mohammad Reza, Huang Su, Murphy Michael P., Safa Ahmad R., 4-(4-Chloro-2-methylphenoxy)-N-hydroxybutanamide (CMH) targets mRNA of the c-FLIP variants and induces apoptosis in MCF-7 human breast cancer cells, Molecular and Cellular Biochemistry, 342, 1-2, 2010. Crossref

  7. Han Lihui, Zhao Yishu, Jia Xiaoqing, Mathematical modeling identified c-FLIP as an apoptotic switch in death receptor induced apoptosis, Apoptosis, 13, 10, 2008. Crossref

  8. Nagane M., Shimizu S., Mori E., Kataoka S., Shiokawa Y., Predominant antitumor effects by fully human anti-TRAIL-receptor2 (DR5) monoclonal antibodies in human glioma cells in vitro and in vivo, Neuro-Oncology, 12, 7, 2010. Crossref

  9. Kerstan Andreas, Leverkus Martin, Trautmann Axel, Effector pathways during eczematous dermatitis: where inflammation meets cell death, Experimental Dermatology, 18, 10, 2009. Crossref

  10. Geserick Peter, Hupe Mike, Moulin Maryline, Wong W. Wei-Lynn, Feoktistova Maria, Kellert Beate, Gollnick Harald, Silke John, Leverkus Martin, Cellular IAPs inhibit a cryptic CD95-induced cell death by limiting RIP1 kinase recruitment, Journal of Cell Biology, 187, 7, 2009. Crossref

  11. Raclaw Kristin A., Heemers Hannelore V., Kidd Emily M., Dehm Scott M., Tindall Donald J., Induction of FLIP expression by androgens protects prostate cancer cells from TRAIL-mediated apoptosis, The Prostate, 68, 15, 2008. Crossref

  12. Plati Jessica, Bucur Octavian, Khosravi‐Far Roya, Dysregulation of apoptotic signaling in cancer: Molecular mechanisms and therapeutic opportunities, Journal of Cellular Biochemistry, 104, 4, 2008. Crossref

  13. Yang Jin Kuk, FLIP as an Anti-Cancer Therapeutic Target, Yonsei Medical Journal, 49, 1, 2008. Crossref

  14. Darvas Katalin, Rosenberger Simone, Brenner Dirk, Fritsch Cornelius, Gmelin Nadine, Krammer Peter H., Rösl Frank, Histone deacetylase inhibitor-induced sensitization to TNFα/TRAIL-mediated apoptosis in cervical carcinoma cells is dependent on HPV oncogene expression, International Journal of Cancer, 127, 6, 2010. Crossref

  15. Servais H., Ortiz A., Devuyst O., Denamur S., Tulkens P. M., Mingeot-Leclercq M.-P., Renal cell apoptosis induced by nephrotoxic drugs: cellular and molecular mechanisms and potential approaches to modulation, Apoptosis, 13, 1, 2008. Crossref

  16. Conus Sébastien , Perozzo Remo , Reinheckel Thomas , Peters Christoph , Scapozza Leonardo , Yousefi Shida , Simon Hans-Uwe , Caspase-8 is activated by cathepsin D initiating neutrophil apoptosis during the resolution of inflammation , Journal of Experimental Medicine, 205, 3, 2008. Crossref

  17. Kim Sung-Su, Won So-Jung, Kim Nam Jae, Yoo Jae Kuk, Bae KiHwan, Lee Kyung-Tae, 3-Oxoolean-12-en-27-oic Acid Isolated from Aceriphyllum rossii Induces Caspase-8-Dependent Apoptosis in Human Promyelocytic Leukemia HL-60 Cells, Biological and Pharmaceutical Bulletin, 32, 1, 2009. Crossref

  18. Schmidt Marc, Hupe Mike, Endres Nicole, Raghavan Badrinarayanan, Kavuri Shyam, Geserick Peter, Goebeler Matthias, Leverkus Martin, The contact allergen nickel sensitizes primary human endothelial cells and keratinocytes to TRAIL-mediated apoptosis, Journal of Cellular and Molecular Medicine, 14, 6b, 2009. Crossref

  19. Hori Takeshi, Kondo Takashi, Kanamori Masahiko, Tabuchi Yoshiaki, Ogawa Ryohei, Zhao Qing-Li, Ahmed Kanwal, Yasuda Taketoshi, Seki Shoji, Suzuki Kayo, Kimura Tomoatsu, Ionizing radiation enhances tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-induced apoptosis through up-regulations of death receptor 4 (DR4) and death receptor 5 (DR5) in human osteosarcoma cells, Journal of Orthopaedic Research, 28, 6, 2010. Crossref

  20. Seto Shintaro, Kurita-Ochiai Tomoko, Ochiai Kuniyasu, Increased susceptibility to tumor necrosis factor-α in butyric acid-induced apoptosis is caused by downregulation of cFLIP expression in Jurkat T cells, Microbiology and Immunology, 52, 3, 2008. Crossref

  21. Leverkus Martin, Diessenbacher Philip, Geserick Peter, FLIP ing the coin? Death receptor-mediated signals during skin tumorigenesis, Experimental Dermatology, 17, 7, 2008. Crossref

  22. Lim Dae-Seog, Bae Yong-Soo, Metastatic lymph node 51 and fibroblast-like synoviocyte hyperproliferation in rheumatoid arthritis pathogenesis, Rheumatology International, 31, 7, 2011. Crossref

  23. Saleem Mohammad, Murtaza Imtiyaz, Witkowsky Olya, Kohl Amanda Marie, Maddodi Nityanand, Lupeol triterpene, a novel diet-based microtubule targeting agent: Disrupts survivin/cFLIP activation in prostate cancer cells, Biochemical and Biophysical Research Communications, 388, 3, 2009. Crossref

  24. Zhao Jing, Lu Yixin, Shen Han-Ming, Targeting p53 as a therapeutic strategy in sensitizing TRAIL-induced apoptosis in cancer cells, Cancer Letters, 314, 1, 2012. Crossref

  25. Fischer-Posovszky Pamela, Keuper Michaela, Nagel Stella, Hesse Deike, Schürmann Annette, Debatin Klaus-Michael, Strauss Gudrun, Wabitsch Martin, Downregulation of FLIP by cycloheximide sensitizes human fat cells to CD95-induced apoptosis, Experimental Cell Research, 317, 15, 2011. Crossref

  26. Yamada Yuriko, Taketani Shigeru, Osada Hiroyuki, Kataoka Takao, Cytotrienin A, a translation inhibitor that induces ectodomain shedding of TNF receptor 1 via activation of ERK and p38 MAP kinase, European Journal of Pharmacology, 667, 1-3, 2011. Crossref

  27. Fang Yujiang, Sharp Gordon C., Braley-Mullen Helen, Effect of Transgenic Overexpression of FLIP on Lymphocytes on Development and Resolution of Experimental Autoimmune Thyroiditis, The American Journal of Pathology, 179, 3, 2011. Crossref

  28. Su Ling, Liu Guangbo, Hao Xuexi, Zhong Ning, Zhong Diansheng, Liu Xiangguo, Singhal Sunil, Death Receptor 5 and cellular FLICE-inhibitory protein regulate pemetrexed-induced apoptosis in human lung cancer cells, European Journal of Cancer, 47, 16, 2011. Crossref

  29. Ren Jun, Babcock Sara A., Li Qun, Huff Anna F., Li Shi-Yan, Doser Thomas A., Aldehyde dehydrogenase-2 transgene ameliorates chronic alcohol ingestion-induced apoptosis in cerebral cortex, Toxicology Letters, 187, 3, 2009. Crossref

  30. Duiker Evelien W., van der Zee Ate G.J., de Graeff Pauline, Boersma-van Ek Wytske, Hollema Harry, de Bock Geertruida H., de Jong Steven, de Vries Elisabeth G.E., The extrinsic apoptosis pathway and its prognostic impact in ovarian cancer, Gynecologic Oncology, 116, 3, 2010. Crossref

  31. García-Fuster M.J., Ramos-Miguel A., Rivero G., La Harpe R., Meana J.J., García-Sevilla J.A., Regulation of the extrinsic and intrinsic apoptotic pathways in the prefrontal cortex of short- and long-term human opiate abusers, Neuroscience, 157, 1, 2008. Crossref

  32. Niedermeier Marianne, Pap Thomas, Korb Adelheid, Therapeutic opportunities in fibroblasts in inflammatory arthritis, Best Practice & Research Clinical Rheumatology, 24, 4, 2010. Crossref

  33. Zhang Shuhong, Suvannasankha Attaya, Crean Colin D., White Valerie L., Chen Ching-Shih, Farag Sherif S., The novel histone deacetylase inhibitor, AR-42, inhibits gp130/Stat3 pathway and induces apoptosis and cell cycle arrest in multiple myeloma cells, International Journal of Cancer, 129, 1, 2011. Crossref

  34. Chinen Takumi, Nagumo Yoko, Watanabe Tsubasa, Imaizumi Takamichi, Shibuya Masatoshi, Kataoka Takao, Kanoh Naoki, Iwabuchi Yoshiharu, Usui Takeo, Irciniastatin A induces JNK activation that is involved in caspase-8-dependent apoptosis via the mitochondrial pathway, Toxicology Letters, 199, 3, 2010. Crossref

  35. Dash Philip R., McCormick James, Thomson Mika J.C.B., Johnstone Alan P., Cartwright Judith E., Whitley Guy StJ., Fas ligand-induced apoptosis is regulated by nitric oxide through the inhibition of fas receptor clustering and the nitrosylation of protein kinase Cε, Experimental Cell Research, 313, 16, 2007. Crossref

  36. El-Gazzar Ahmed, Wittinger Michael, Perco Paul, Anees Mariam, Horvat Reinhard, Mikulits Wolfgang, Grunt Thomas W., Mayer Bernd, Krainer Michael, The role of c-FLIPL in ovarian cancer: Chaperoning tumor cells from immunosurveillance and increasing their invasive potential, Gynecologic Oncology, 117, 3, 2010. Crossref

  37. González Raúl, Ferrín Gustavo, Aguilar-Melero Patricia, Ranchal Isidora, Linares Clara I., Bello Rosario I., De la Mata Manuel, Gogvadze Vladimir, Bárcena José A., Álamo José M., Orrenius Sten, Padillo Francisco J., Zhivotovsky Boris, Muntané Jordi, Targeting Hepatoma Using Nitric Oxide Donor Strategies, Antioxidants & Redox Signaling, 18, 5, 2013. Crossref

  38. Kataoka Takao, Translation inhibitors and their unique biological properties, European Journal of Pharmacology, 676, 1-3, 2012. Crossref

  39. Turk Boris, Stoka Veronika, Protease signalling in cell death: caspases versus cysteine cathepsins, FEBS Letters, 581, 15, 2007. Crossref

  40. Min Kyoung-jin, Jang Ji Hoon, Lee Jung Tae, Choi Kyeong Sook, Kwon Taeg Kyu, Glucocorticoid receptor antagonist sensitizes TRAIL-induced apoptosis in renal carcinoma cells through up-regulation of DR5 and down-regulation of c-FLIP(L) and Bcl-2, Journal of Molecular Medicine, 90, 3, 2012. Crossref

  41. Duiker E.W., Mom C.H., de Jong S., Willemse P.H.B., Gietema J.A., van der Zee A.G.J., de Vries E.G.E., The clinical trail of TRAIL, European Journal of Cancer, 42, 14, 2006. Crossref

  42. Uesugi Kazuhiro, Hiasa Yoichi, Tokumoto Yoshio, Mashiba Toshie, Koizumi Yohei, Hirooka Masashi, Abe Masanori, Matsuura Bunzo, Onji Morikazu, Wilms’ tumor 1 gene modulates Fas-related death signals and anti-apoptotic functions in hepatocellular carcinoma, Journal of Gastroenterology, 48, 9, 2013. Crossref

  43. Tian F., Lu J. J., Wang L., Li L., Yang J., Li Y., Liu Y. Q., Shen G. X., Tu Y. T., Tao J., Expression of c-FLIP in malignant melanoma, and its relationship with the clinicopathological features of the disease, Clinical and Experimental Dermatology, 37, 3, 2012. Crossref

  44. Bremer Edwin, Targeting of the Tumor Necrosis Factor Receptor Superfamily for Cancer Immunotherapy, ISRN Oncology, 2013, 2013. Crossref

  45. Schmid Sandra J., Glatzel Marie-Charlotte, Welke Claudia, Kornmann Marko, Kleger Alexander, Barth Thomas F. E., Fulda Simone, Lennerz Jochen K., Möller Peter, Absence of FLICE-Inhibitory Protein Is a Novel Independent Prognostic Marker for Very Short Survival in Pancreatic Ductal Adenocarcinoma, Pancreas, 42, 7, 2013. Crossref

  46. Koenig Andreas, Sateriale Adam, Budd Ralph C., Huber Sally A., Buskiewicz Iwona A., The Role of Sex Differences in Autophagy in the Heart During Coxsackievirus B3-Induced Myocarditis, Journal of Cardiovascular Translational Research, 7, 2, 2014. Crossref

  47. Rashmi Ramachandran, Schnulle Patricia M, Maddox Allison C, Armbrecht Eric S, Koenig Joyce M, Flice Inhibitory Protein Is Associated With the Survival of Neonatal Neutrophils, Pediatric Research, 70, 4, 2011. Crossref

  48. Sastalla Inka, Crown Devorah, Masters Seth L, McKenzie Andrew, Leppla Stephen H, Moayeri Mahtab, Transcriptional analysis of the three Nlrp1 paralogs in mice, BMC Genomics, 14, 1, 2013. Crossref

  49. Tsuda Hiromasa, Ning Zhao, Yamaguchi Yoko, Suzuki Naoto, Programmed cell death and its possible relationship with periodontal disease, Journal of Oral Science, 54, 2, 2012. Crossref

  50. Panganiban Ronald-Allan, Snow Andrew, Day Regina, Mechanisms of Radiation Toxicity in Transformed and Non-Transformed Cells, International Journal of Molecular Sciences, 14, 8, 2013. Crossref

  51. Xu Li-Xia, Grimaldo Sammy, Qi Jian-Wei, Yang Gui-Li, Qin Ting-Ting, Xiao Huai-Yuan, Xiang Rong, Xiao Zhixiong, Li Lu-Yuan, Zhang Zhi-Song, Death receptor 3 mediates TNFSF15- and TNFα-induced endothelial cell apoptosis, The International Journal of Biochemistry & Cell Biology, 55, 2014. Crossref

  52. Feoktistova Maria, Leverkus Martin, Programmed necrosis and necroptosis signalling, FEBS Journal, 282, 1, 2015. Crossref

  53. García-Fuster M. Julia, García-Sevilla Jesús A., Monoamine receptor agonists, acting preferentially at presynaptic autoreceptors and heteroreceptors, downregulate the cell fate adaptor FADD in rat brain cortex, Neuropharmacology, 89, 2015. Crossref

  54. Elia Androulla, Powley Ian R., MacFarlane Marion, Clemens Michael J., Modulation of the Sensitivity of Jurkat T-Cells to Inhibition of Protein Synthesis by Tumor Necrosis Factor α-Related Apoptosis-Inducing Ligand, Journal of Interferon & Cytokine Research, 34, 10, 2014. Crossref

  55. Keller Benjamin, García-Sevilla Jesús A., Regulation of hippocampal Fas receptor and death-inducing signaling complex after kainic acid treatment in mice, Progress in Neuro-Psychopharmacology and Biological Psychiatry, 63, 2015. Crossref

  56. Gajate Consuelo, Mollinedo Faustino, Lipid rafts and raft-mediated supramolecular entities in the regulation of CD95 death receptor apoptotic signaling, Apoptosis, 20, 5, 2015. Crossref

  57. Fan Songqing, Li Yikun, Yue Ping, Khuri Fadlo R., Sun Shi-Yong, The eIF4E/eIF4G Interaction Inhibitor 4EGI-1 Augments TRAIL-Mediated Apoptosis through c-FLIP Down-regulation and DR5 Induction Independent of Inhibition of Cap-Dependent Protein Translation, Neoplasia, 12, 4, 2010. Crossref

  58. Yamaguchi Yumi, Shiraki Katsuya, Fuke Hiroyuki, Inoue Tomoko, Miyashita Kazumi, Yamanaka Yutaka, Nakano Takeshi, Adenovirus-mediated transfection of caspase-8 sensitizes hepatocellular carcinoma to TRAIL- and chemotherapeutic agent-induced cell death, Biochimica et Biophysica Acta (BBA) - Molecular Cell Research, 1763, 8, 2006. Crossref

  59. Lin Yidan, Wang Yu, Liu Xianfang, Yan Jiamei, Su Ling, Liu Xiangguo, A novel derivative of tetrandrine (H1) induces endoplasmic reticulum stress-mediated apoptosis and prosurvival autophagy in human non-small cell lung cancer cells, Tumor Biology, 37, 8, 2016. Crossref

  60. Högstrand Kari, Hejll Eduar, Sander Birgitta, Rozell Björn, Larsson Lars-Gunnar, Grandien Alf, Bunting Kevin D., Inhibition of the Intrinsic but Not the Extrinsic Apoptosis Pathway Accelerates and Drives Myc-Driven Tumorigenesis Towards Acute Myeloid Leukemia, PLoS ONE, 7, 2, 2012. Crossref

  61. García-Fuster M. Julia, García-Sevilla Jesús A., Effects of anti-depressant treatments on FADD and p-FADD protein in rat brain cortex: enhanced anti-apoptotic p-FADD/FADD ratio after chronic desipramine and fluoxetine administration, Psychopharmacology, 233, 15-16, 2016. Crossref

  62. Liu Xiangguo, Sun Shi-Yong, FLICE-Inhibitory Protein, in Encyclopedia of Cancer, 2014. Crossref

  63. Lizarraga Floria, Ceballos-Cancino Gisela, Espinosa Magali, Vazquez-Santillan Karla, Maldonado Vilma, Melendez-Zajgla Jorge, Sang Qing-Xiang Amy, Tissue Inhibitor of Metalloproteinase-4 Triggers Apoptosis in Cervical Cancer Cells, PLOS ONE, 10, 8, 2015. Crossref

  64. Yao Qian, Du Juan, Lin Jie, Luo Yiming, Wang Yuxiang, Liu Yan, Zhang Bo, Ren Caixia, Liu Congrong, Prognostic significance of TRAIL signalling molecules in cervical squamous cell carcinoma, Journal of Clinical Pathology, 69, 2, 2016. Crossref

  65. Adameova Adriana, Goncalvesova Eva, Szobi Adrian, Dhalla Naranjan S., Necroptotic cell death in failing heart: relevance and proposed mechanisms, Heart Failure Reviews, 21, 2, 2016. Crossref

  66. He Ying-Chun, Zhou Fang-Liang, Shen Yi, Liao Duan-Fang, Cao Deliang, Apoptotic Death of Cancer Stem Cells for Cancer Therapy, International Journal of Molecular Sciences, 15, 5, 2014. Crossref

  67. LUAN ZHOU, HE YING, HE FAN, CHEN ZHISHUI, Rocaglamide overcomes tumor necrosis factor-related apoptosis-inducing ligand resistance in hepatocellular carcinoma cells by attenuating the inhibition of caspase-8 through cellular FLICE-like-inhibitory protein downregulation, Molecular Medicine Reports, 11, 1, 2015. Crossref

  68. Zhao Xingwei, Zhang Qiang, Chen Liang, Triptolide induces the cell apoptosis of osteosarcoma cells through the TRAIL pathway, Oncology Reports, 36, 3, 2016. Crossref

  69. TIAN FEN, HU YANGE, SUN XIXI, LU GAIHUI, LI YAN, YANG JING, TAO JUAN, Suppression of c-FLIPL promotes JNK activation in malignant melanoma cells, Molecular Medicine Reports, 13, 3, 2016. Crossref

  70. Sun Jichun, Yu Xiao, Wang Changfa, Yu Can, Li Zhiqiang, Nie Wanpin, Xu Xundi, Miao Xiongying, Jin Xiaoxin, RIP-1/c-FLIPL Induce Hepatic Cancer Cell Apoptosis Through Regulating Tumor Necrosis Factor-Related Apoptosis-Inducing Ligand (TRAIL), Medical Science Monitor, 23, 2017. Crossref

  71. Rippo M.R., Villanova F., Ardori F. Tomassoni, Graciotti L., Amatori S., Manzotti S., Fanelli M., Gigante A., Procopio A., Dexamethasone Affects FAS-and Serum Deprivation-Induced Cell Death of Human Osteoblastic Cells through Survivin Regulation, International Journal of Immunopathology and Pharmacology, 23, 4, 2010. Crossref

  72. Liu Xiangguo, Sun Shi-Yong, FLICE-Inhibitory Protein, in Encyclopedia of Cancer, 2014. Crossref

  73. Harada Misuzu, Morimoto Kyoko, Kondo Tetsuya, Hiramatsu Reiko, Okina Yuji, Muko Ryo, Matsuda Iyo, Kataoka Takao, Quinacrine Inhibits ICAM-1 Transcription by Blocking DNA Binding of the NF-κB Subunit p65 and Sensitizes Human Lung Adenocarcinoma A549 Cells to TNF-α and the Fas Ligand, International Journal of Molecular Sciences, 18, 12, 2017. Crossref

  74. Kong Wei, Mou Xiaoyang, Deng Jin, Di Benteng, Zhong Ruxing, Wang Shuaiqun, Yang Yang, Zeng Weiming, Li Xia, Differences of immune disorders between Alzheimer’s disease and breast cancer based on transcriptional regulation, PLOS ONE, 12, 7, 2017. Crossref

  75. Kyläniemi Minna K., Kaukonen Riina, Myllyviita Johanna, Rasool Omid, Lahesmaa Riitta, Tasken Kjetil, The Regulation and Role of c-FLIP in Human Th Cell Differentiation, PLoS ONE, 9, 7, 2014. Crossref

  76. Liu Xiangguo, Sun Shi-Yong, FLICE Inhibitory Protein, in Encyclopedia of Cancer, 2011. Crossref

  77. Upadrasta Sindhuri, Saini Neeru, Proteases and Their Role in Drug Development with an Emphasis in Cancer, in Role of Proteases in Cellular Dysfunction, 2014. Crossref

  78. Benayoun Béatrice, Baghdiguian Stephen, Lajmanovich Alicia, Bartoli Marc, Daniele Nathalie, Gicquel Evelyne, Bourg Nathalie, Raynaud Fabrice, Pasquier Marie‐Anne, Suel Laurence, Lochmuller Hanns, Lefranc Gérard, Richard Isabelle, NF‐NF‐κBB‐dependent expression of the antiapoptotic factor c‐FLIP is regulated by calpain 3, the protein involved in limb‐girdle muscular dystrophy type 2A, The FASEB Journal, 22, 5, 2008. Crossref

  79. Gong Ping, Li Kun, Li Ying, Liu Dan, Zhao Linxiang, Jing Yongkui, HDAC and Ku70 axis- an effective target for apoptosis induction by a new 2-cyano-3-oxo-1,9-dien glycyrrhetinic acid analogue, Cell Death & Disease, 9, 6, 2018. Crossref

  80. Huang Yuefeng, Chen Liang, Zhou Yi, Liu Heng, Yang Jueqing, Liu Zhenggang, Wang Chen, Heldin Carl-Henrik, UXT-V1 protects cells against TNF-induced apoptosis through modulating complex II formation, Molecular Biology of the Cell, 22, 8, 2011. Crossref

  81. Liu Ying Xun, Huang Jian Yuan, Wang Dong Liang, Wang Jin Ke, Identification of DMSA-Coated Fe<sub>3</sub>O<sub>4</sub> Nanoparticles Induced-Apoptosis Response Genes in Human Monocytes by cDNA Microarrays, Advanced Materials Research, 749, 2013. Crossref

  82. Luebke Tobias, Schwarz Lisa, Beer Yan Yan, Schumann Sabrina, Misterek Maria, Sander Frida Ewald, Plaza-Sirvent Carlos, Schmitz Ingo, c-FLIP and CD95 signaling are essential for survival of renal cell carcinoma, Cell Death & Disease, 10, 6, 2019. Crossref

  83. Mollinedo Faustino, Death Receptors in Multiple Myeloma and Therapeutic Opportunities, in Myeloma Therapy, 2008. Crossref

  84. Younossi Zobair M., Afendy Arian, Stepanova Maria, Hossain Noreen, Younossi Issah, Ankrah Kathy, Gramlich Terry, Baranova Ancha, Gene expression profile associated with superimposed non-alcoholic fatty liver disease and hepatic fibrosis in patients with chronic hepatitis C, Liver International, 29, 9, 2009. Crossref

  85. Frommer Friederike, Heinen Tobias J. A. J., Wunderlich F. Thomas, Yogev Nir, Buch Thorsten, Roers Axel, Bettelli Estelle, Müller Werner, Anderton Stephen M., Waisman Ari, Tolerance without Clonal Expansion: Self-Antigen-Expressing B Cells Program Self-Reactive T Cells for Future Deletion, The Journal of Immunology, 181, 8, 2008. Crossref

  86. Shimada Keiji, Nakamura Mitsutoshi, Matsuyoshi Syuichi, Ishida Eiwa, Konishi Noboru, Specific positive and negative effects of FLIP on cell survival in human prostate cancer, Carcinogenesis, 27, 7, 2006. Crossref

  87. Shi Puyu, Zhang Shuo, Zhu Lei, Qian Guoqing, Ren Hui, Ramalingam Suresh S., Chen Mingwei, Sun Shi-Yong, The Third-Generation EGFR Inhibitor, Osimertinib, Promotes c-FLIP Degradation, Enhancing Apoptosis Including TRAIL-Induced Apoptosis in NSCLC Cells with Activating EGFR Mutations, Translational Oncology, 12, 5, 2019. Crossref

  88. Azad Neelam, Iyer Anand Krishnan V., Reactive Oxygen Species and Apoptosis, in Systems Biology of Free Radicals and Antioxidants, 2014. Crossref

  89. Iyer Anand Krishnan V., Azad Neelam, Talbot Siera, Stehlik Christian, Lu Bin, Wang Liying, Rojanasakul Yon, Antioxidant c-FLIP Inhibits Fas Ligand-Induced NF-κB Activation in a Phosphatidylinositol 3-Kinase/Akt-Dependent Manner, The Journal of Immunology, 187, 6, 2011. Crossref

  90. Perez Lia Elena, Parquet Nancy, Shain Kenneth, Nimmanapalli Ramadevi, Alsina Melissa, Anasetti Claudio, Dalton William, Bone Marrow Stroma Confers Resistance to Apo2 Ligand/TRAIL in Multiple Myeloma in Part by Regulating c-FLIP, The Journal of Immunology, 180, 3, 2008. Crossref

  91. Kim Eun-Ae, Kim Sang-Woo, Nam Jehyun, Sung Eon-Gi, Song In-Hwan, Kim Joo-Young, Kwon Taeg Kyu, Lee Tae-Jin, Inhibition of c-FLIPL expression by miRNA-708 increases the sensitivity of renal cancer cells to anti-cancer drugs, Oncotarget, 7, 22, 2016. Crossref

  92. Du Juan, Wu Jinfeng, Fu Xiuqiong, Kai-Wing Tse Anfernee, Li Ting, Su Tao, Yu Zhi-Ling, Icariside II overcomes TRAIL resistance of melanoma cells through ROS-mediated downregulation of STAT3/cFLIP signaling, Oncotarget, 7, 32, 2016. Crossref

  93. Fang Yujiang, DeMarco Vincent G., Sharp Gordon C., Braley-Mullen Helen, Expression of Transgenic FLIP on Thyroid Epithelial Cells Inhibits Induction and Promotes Resolution of Granulomatous Experimental Autoimmune Thyroiditis in CBA/J Mice, Endocrinology, 148, 12, 2007. Crossref

  94. Bredholt Therese, Dimba Elizabeth AO, Hagland Hanne R, Wergeland Line, Skavland Jørn, Fossan Kjell O, Tronstad Karl J, Johannessen Anne C, Vintermyr Olav K, Gjertsen Bjørn T, Camptothecin and khat (Catha edulis Forsk.) induced distinct cell death phenotypes involving modulation of c-FLIPL, Mcl-1, procaspase-8 and mitochondrial function in acute myeloid leukemia cell lines, Molecular Cancer, 8, 1, 2009. Crossref

  95. Matsuda Iyo, Matsuo Kentaro, Matsushita Yuka, Haruna Yasushi, Niwa Masamitsu, Kataoka Takao, The C-terminal Domain of the Long Form of Cellular FLICE-inhibitory Protein (c-FLIPL) Inhibits the Interaction of the Caspase 8 Prodomain with the Receptor-interacting Protein 1 (RIP1) Death Domain and Regulates Caspase 8-dependent Nuclear Factor κB (NF-κB) Activation, Journal of Biological Chemistry, 289, 7, 2014. Crossref

  96. Chen Shuzhen, Fu Lei, Raja Shruti M, Yue Ping, Khuri Fadlo R, Sun Shi-Yong, Dissecting the roles of DR4, DR5 and c-FLIP in the regulation of Geranylgeranyltransferase I inhibition-mediated augmentation of TRAIL-induced apoptosis, Molecular Cancer, 9, 1, 2010. Crossref

  97. Kadohara Kimiko, Nagumo Michiko, Asami Shun, Tsukumo Yoshinori, Sugimoto Hikaru, Igarashi Masayuki, Nagai Kazuo, Kataoka Takao, Caspase-8 Mediates Mitochondrial Release of Pro-apoptotic Proteins in a Manner Independent of Its Proteolytic Activity in Apoptosis Induced by the Protein Synthesis Inhibitor Acetoxycycloheximide in Human Leukemia Jurkat Cells, Journal of Biological Chemistry, 284, 9, 2009. Crossref

  98. Yu Guang, Mao Jianning, Wu Yulian, Luo Hongyu, Wu Jiangping, Ephrin-B1 Is Critical in T-cell Development, Journal of Biological Chemistry, 281, 15, 2006. Crossref

  99. Liang Ya-Han, Wu Jiann-Ming, Teng Jui-Wen, Hung Eric, Wang Hwai-Shi, Embelin downregulated cFLIP in breast cancer cell lines facilitate anti-tumor effect of IL-1β-stimulated human umbilical cord mesenchymal stem cells, Scientific Reports, 11, 1, 2021. Crossref

  100. Xu Fei, Wu Qiaolan, Li Lei, Gong Jie, Huo Ran, Cui Wenqiang, Icariside II: Anticancer Potential and Molecular Targets in Solid Cancers, Frontiers in Pharmacology, 12, 2021. Crossref

  101. Oh You-Take, Sun Shi-Yong, Regulation of Cancer Metastasis by TRAIL/Death Receptor Signaling, Biomolecules, 11, 4, 2021. Crossref

  102. Lee Ah Ram, Park Yong Kwang, Dezhbord Mehrangiz, Kim Kyun-Hwan, Interaction between the Hepatitis B Virus and Cellular FLIP Variants in Viral Replication and the Innate Immune System, Viruses, 14, 2, 2022. Crossref

  103. Takada Yohei, Matsuo Kentaro, Ogura Hirotsugu, Bai Liming, Toki Asami, Wang Liyan, Ando Masayoshi, Kataoka Takao, Odoroside A and ouabain inhibit Na+/K+-ATPase and prevent NF-κB-inducible protein expression by blocking Na+-dependent amino acid transport, Biochemical Pharmacology, 78, 9, 2009. Crossref

  104. Geserick P, Drewniok C, Hupe M, Haas T L, Diessenbacher P, Sprick M R, Schön M P, Henkler F, Gollnick H, Walczak H, Leverkus M, Suppression of cFLIP is sufficient to sensitize human melanoma cells to TRAIL- and CD95L-mediated apoptosis, Oncogene, 27, 22, 2008. Crossref

  105. Helfer Brooke, Boswell Bernard C., Finlay Darren, Cipres Angel, Vuori Kristiina, Bong Kang Tae, Wallach David, Dorfleutner Andrea, Lahti Jill M., Flynn Daniel C., Frisch Steven M., Caspase-8 Promotes Cell Motility and Calpain Activity under Nonapoptotic Conditions, Cancer Research, 66, 8, 2006. Crossref

  106. Raja Shruti M., Chen Shuzhen, Yue Ping, Acker Timothy M., Lefkove Benjamin, Arbiser Jack L., Khuri Fadlo R., Sun Shi-Yong, The natural product honokiol preferentially inhibits cellular FLICE-inhibitory protein and augments death receptor–induced apoptosis, Molecular Cancer Therapeutics, 7, 7, 2008. Crossref

  107. Murtaza Imtiyaz, Saleem Mohammad, Adhami Vaqar Mustafa, Hafeez Bilal Bin, Mukhtar Hasan, Suppression of cFLIP by Lupeol, a Dietary Triterpene, Is Sufficient to Overcome Resistance to TRAIL-Mediated Apoptosis in Chemoresistant Human Pancreatic Cancer Cells, Cancer Research, 69, 3, 2009. Crossref

  108. Roca Hernan, Varsos Zachary S., Sud Sudha, Craig Matthew J., Ying Chi, Pienta Kenneth J., CCL2 and Interleukin-6 Promote Survival of Human CD11b+ Peripheral Blood Mononuclear Cells and Induce M2-type Macrophage Polarization, Journal of Biological Chemistry, 284, 49, 2009. Crossref

  109. Wang S, The promise of cancer therapeutics targeting the TNF-related apoptosis-inducing ligand and TRAIL receptor pathway, Oncogene, 27, 48, 2008. Crossref

  110. Suvannasankha Attaya, Crean Colin D., Shanmugam Rajasubramaniam, Farag Sherif S., Abonour Rafat, Boswell H. Scott, Nakshatri Harikrishna, Antimyeloma Effects of a Sesquiterpene Lactone Parthenolide, Clinical Cancer Research, 14, 6, 2008. Crossref

  111. Elrod Heath A., Lin Yi-Dan, Yue Ping, Wang Xuerong, Lonial Sagar, Khuri Fadlo R., Sun Shi-Yong, The alkylphospholipid perifosine induces apoptosis of human lung cancer cells requiring inhibition of Akt and activation of the extrinsic apoptotic pathway, Molecular Cancer Therapeutics, 6, 7, 2007. Crossref

  112. Hori Takeshi, Kondo Takashi, Kanamori Masahiko, Tabuchi Yoshiaki, Ogawa Ryohei, Zhao Qing-Li, Ahmed Kanwal, Yasuda Taketoshi, Seki Shoji, Suzuki Kayo, Kimura Tomoatsu, Nutlin-3 enhances tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-induced apoptosis through up-regulation of death receptor 5 (DR5) in human sarcoma HOS cells and human colon cancer HCT116 cells, Cancer Letters, 287, 1, 2010. Crossref

  113. Rae Colin, Langa Susana, Tucker Steven J., MacEwan David J., Elevated NF-κB responses and FLIP levels in leukemic but not normal lymphocytes: reduction by salicylate allows TNF-induced apoptosis, Proceedings of the National Academy of Sciences, 104, 31, 2007. Crossref

  114. Ogura Hirotsugu, Tsukumo Yoshinori, Sugimoto Hikaru, Igarashi Masayuki, Nagai Kazuo, Kataoka Takao, Ectodomain shedding of TNF receptor 1 induced by protein synthesis inhibitors regulates TNF-α-mediated activation of NF-κB and caspase-8, Experimental Cell Research, 314, 6, 2008. Crossref

  115. Sohn Dennis, Totzke Gudrun, Essmann Frank, Schulze-Osthoff Klaus, Levkau Bodo, Jänicke Reiner U., The Proteasome Is Required for Rapid Initiation of Death Receptor-Induced Apoptosis, Molecular and Cellular Biology, 26, 5, 2006. Crossref

  116. Kavuri Shyam M., Geserick Peter, Berg Daniela, Dimitrova Diana Panayotova, Feoktistova Maria, Siegmund Daniela, Gollnick Harald, Neumann Manfred, Wajant Harald, Leverkus Martin, Cellular FLICE-inhibitory Protein (cFLIP) Isoforms Block CD95- and TRAIL Death Receptor-induced Gene Induction Irrespective of Processing of Caspase-8 or cFLIP in the Death-inducing Signaling Complex, Journal of Biological Chemistry, 286, 19, 2011. Crossref

  117. Li Bo, Ren Hui, Yue Ping, Chen Mingwei, Khuri Fadlo R., Sun Shi-Yong, The Novel Akt Inhibitor API-1 Induces c-FLIP Degradation and Synergizes with TRAIL to Augment Apoptosis Independent of Akt Inhibition, Cancer Prevention Research, 5, 4, 2012. Crossref

  118. Martelli A M, Nyåkern M, Tabellini G, Bortul R, Tazzari P L, Evangelisti C, Cocco L, Phosphoinositide 3-kinase/Akt signaling pathway and its therapeutical implications for human acute myeloid leukemia, Leukemia, 20, 6, 2006. Crossref

  119. Fulda Simone, Pervaiz Shazib, Apoptosis signaling in cancer stem cells, The International Journal of Biochemistry & Cell Biology, 42, 1, 2010. Crossref

  120. Bedoui Sammy, Herold Marco J., Strasser Andreas, Emerging connectivity of programmed cell death pathways and its physiological implications, Nature Reviews Molecular Cell Biology, 21, 11, 2020. Crossref

  121. Kubo Satoshi, Kataria Rhea, Yao Yikun, Gabrielski Justin Q., Zheng Lixin, Markowitz Tovah E., Chan Waipan, Song Jian, Boddapati Arun K., Saeki Keita, Häupl Björn, Park Ann Y., Cheng Yan H., Cui Jing, Oellerich Thomas, Lenardo Michael J., Early B cell factor 4 modulates FAS-mediated apoptosis and promotes cytotoxic function in human immune cells, Proceedings of the National Academy of Sciences, 119, 33, 2022. Crossref

  122. Sun Shi-Yong, Targeting apoptosis to manage acquired resistance to third generation EGFR inhibitors, Frontiers of Medicine, 2022. Crossref

  123. Jia Song Hui, Parodo Jean, Kapus Andras, Rotstein Ori D., Marshall John C., Dynamic Regulation of Neutrophil Survival through Tyrosine Phosphorylation or Dephosphorylation of Caspase-8, Journal of Biological Chemistry, 283, 9, 2008. Crossref

  124. Jang Ji, Lee Tae-Jin, Sung Eon-Gi, Song In-Hwan, Kim Joo-Young, Dapagliflozin induces apoptosis by downregulating cFILPL and increasing cFILPS instability in Caki‑1 cells, Oncology Letters, 24, 5, 2022. Crossref

将发表的论文

Identification of a novel five-gene prognostic model for laryngeal cancer associated with mitophagy using integrated bioinformatics analysis and experimental verification Dong Song, Lun Dong, Mei Wang, Xiaoping Gao Function of steroid receptor coactivators (SRCs) in T cells and cancers: Implications for cancer immunotherapy Wencan Zhang, Xu Cao, Hongmin Wu, Xiancai Zhong, Yun Shi, Zuoming Sun Electroacupuncture Alleviates Ischemic Stroke by Activating the mTOR/SREBP1 Pathway Jiawang Lang, Jianchang Luo, Luodan Wang, Wenbin Xu, Jie Jia, Zhipeng Zhao, Boxu Lang KIAA1429 induces the m6A modification of LINC01106 to enhance the malignancy of lung adenocarcinoma cell via JAK/STAT3 pathway Di Xu, Ziming Wang, Fajiu Li Effect of p-estrogen receptor at serine on its function and breast growth Yuan Liang, Junhui Qin, Tiancheng Ma, Tong Yang, Zhenyu Ke, Ruian Wang Mechanistic Insights into Tanshinone IIA in the Amelioration of Post-Thyroidectomy Hypoparathyroidism Xiaoyu Qian, Lin Li, Liang Chen, Chao Shen, Jian Tang MiRNA let-7d-5p alleviates inflammatory responses by targeting Map3k1 and inactivating ERK/p38 MAPK signaling in microglia Fan Fang, Cheng Chen Role of Natural Killer Cells as Cell-Based Immunotherapy in Oral Tumor Eradication and Differentiation Both In Vivo and In Vitro Kawaljit Kaur, Anahid Jewett The Current and Future States of Natural Killer Cell-Based Immunotherapy in Hepatocellular Carcinoma Tu Nguyen, Po-Chun Chen, Janet Pham, Kawaljit Kaur, Steven Raman, Anahid Jewett, Jason Chiang Phillygenin alleviated arthritis through the inhibition of NLRP3 inflammasome and Ferroptosis by AMPK Jianghui Wang, Shufang Ni, Kai Zheng, Yan Zhao, peihong zhang, Hong Chang The value of systemic immune-inflammation index and T cell subsets in the severity and prognosis of sepsis Hao Zhou Efficacy and Nuances of Precision Molecular Engineering for Hodgkin's Disease to a Gene Therapeutic Approach Muhammad Imran Qadir, Bilal Ahmed, Nadir Hussain Serum interleukin 6 and ferritin levels are the independent risk factors for pneumonia in elderly patients Hao Yuan, Jing Tian, Lu Wen Exploration of diagnostic markers associated with inflammation in chronic kidney disease (CKD) based on WGCNA and machine learning Qianjia Wu, Yang Yang, Chongze Lin Clinical significance of serum CTRP3 level in the prediction of cardiac dysfunction and intestinal mucosal barrier dysfunction in patients with severe acute pancreatitis Qiang Shao, Lin Sun The protective effect and mechanism of mild hypothermia on pig lung injury after cardiopulmonary resuscitation Jinlin Ren, Fangfang Zhu, Dongdong Sang, Mulin Cong, Shujuan Jiang Exploring mechanism of Zilongjin in treating lung adenocarcinoma based on network pharmacology combined with experimental verification Kang Zhang, Xiaoqun Chen Gastric Cancer Immune Subtypes and Prognostic Modeling: Insights from Aging-Related Genes Analysis Jian Shen, Minzhe Li Effects of different doses of dexmedetomidine on the prevention of postoperative sleep disturbance and serum neurotransmitter level in patients under general anesthesia Huifei Lu, Fei He, Ying Huang, Zhongliang Wei Identification of key ubiquitination-related genes and their associated with immune infiltration in osteoarthritis based on mRNA-miRNA network Dalu Yuan, Hailiang Shen, Lina Bai, Menglin Li, Qiujie Ye Diagnostic and Prognostic value of peripheral neutrophil CD64 index in elderly patients with community-acquired pneumonia Yan Li, Jing Zhang, Suhang Wang, Jie Cao Identification of Metabolism-Related Prognostic Biomarkers and Immune Features of Head and Neck Squamous Cell Carcinoma Rongjin Zhou, Junguo Wang Downregulation of miR-503-5p promotes the development of pancreatic cancer via targeting cyclin E2 Fei Li, Ying-pei Ling, Pan Wang, Shi-cheng Gu, Hao Jiang, Jie Zhu
Begell Digital Portal Begell 数字图书馆 电子图书 期刊 参考文献及会议录 研究收集 订购及政策 Begell House 联系我们 Language English 中文 Русский Português German French Spain