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医药载体系统评论综述
影响因子: 2.9 5年影响因子: 3.72 SJR: 0.736 SNIP: 0.551 CiteScore™: 2.43

ISSN 打印: 0743-4863
ISSN 在线: 2162-660X

医药载体系统评论综述

DOI: 10.1615/CritRevTherDrugCarrierSyst.v19.i1.10
72 pages

Pluronic® Block Copolymers in Drug Delivery: from Micellar Nanocontainers to Biological Response Modifiers

Alexander V. Kabanov
College of Pharmacy, Department of Pharmaceutical Sciences, 986025 Nebraska Medical Center, Omaha, NE 68198-6025, USA
Valery Yu. Alakhov
Supratek Pharma Inc., 531 Blvd. des Prairies, Building 18, Laval, Quebec, Canada H7V 1B7

ABSTRACT

Pluronicв block copolymers are recognized pharmaceutical excipients listed in the US and British Pharmacopoeia. The incorporation of drugs into Pluronic micelles results in increased solubility and stability of drugs. Consequently, the micelles are used for delivery of drugs in the body. Pluronic unimers sensitize multidrug-resistant cells by inhibiting drug efflux transporters. This allows for the development of formulations for the treatment of multidrug-resistant and metastatic tumors. Furthermore, these formulations can be used to enhance brain and oral bioavailability of various drugs. Finally, Pluronic formulations were shown to enhance transgene expression in the body. This opens new possibilities for the use of Pluronic in gene therapies.


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