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ISSN 在线: 2162-660X

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Emerging Trends in Oral Delivery of Peptide and Protein Drugs

卷 20, 册 2&3, 2003, 62 pages
DOI: 10.1615/CritRevTherDrugCarrierSyst.v20.i23.30
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摘要

Most peptide and protein drugs are currently used as parenteral formulations because of their poor oral bioavailability. Development of an effective oral delivery system for these macromolecular drugs requires a thorough understanding of their physicochemical properties, such as molecular weight, hydrophobicity, ionization constants, and pH stability, as well as biological barriers that restrict protein and peptide absorption from the gastrointestinal (GI) tract, including pH variability, enzymatic degradation, and membrane efflux. Various strategies currently under investigation include amino acid backbone modifications, formulation approaches, chemical conjugation of hydrophobic or targeting ligand, and use of enzyme inhibitors, mucoadhesive polymers, and absorption enhancers. However, there is only limited success because of the hostile environment of the GI tract-e.g., strong pH extremes and abundant presence of potent luminal enzymes. Th is review focuses on the challenges posed by the GI system and how different pharmaceutical approaches can be used to make oral delivery of protein and peptide drugs more feasible. Th e roles of P-glycoprotein and CYP3A4 in controlling the extent of intestinal absorption and metabolism will also be discussed.

对本文的引用
  1. Tang Lisa, Persky Adam M., Hochhaus Günther, Meibohm Bernd, Pharmacokinetic aspects of biotechnology products, Journal of Pharmaceutical Sciences, 93, 9, 2004. Crossref

  2. Liederer Bianca M., Borchardt Ronald T., Stability of Oxymethyl-Modified Coumarinic Acid Cyclic Prodrugs of Diastereomeric Opioid Peptides in Biological Media from Various Animal Species Including Human, Journal of Pharmaceutical Sciences, 94, 10, 2005. Crossref

  3. Pawar Rajendra, Ben-Ari Alon, Domb Abraham J, Protein and peptide parenteral controlled delivery, Expert Opinion on Biological Therapy, 4, 8, 2004. Crossref

  4. Humphrys Simon, Lapidge Steven J., Delivering and registering species-tailored oral antifertility products: a review, Wildlife Research, 35, 6, 2008. Crossref

  5. Borghouts Corina, Kunz Christian, Groner Bernd, Peptide aptamers: recent developments for cancer therapy, Expert Opinion on Biological Therapy, 5, 6, 2005. Crossref

  6. Salehpour Mehran, Ekblom Jonas, Sabetsky Vladimir, Håkansson Karl, Possnert Göran, Accelerator mass spectrometry offers new opportunities for microdosing of peptide and protein pharmaceuticals, Rapid Communications in Mass Spectrometry, 24, 10, 2010. Crossref

  7. Porvasnik Stacy L., Mah Cathryn, Polyak Steven, Targeting murine small bowel and colon through selective superior mesenteric artery injection, Microsurgery, 30, 6, 2010. Crossref

  8. Hamman Josias H, Enslin Gill M, Kotz?? Awie F, Oral Delivery of Peptide Drugs, BioDrugs, 19, 3, 2005. Crossref

  9. Hou Jianhua, Yan Ruixiang, Ding Dongfeng, Yang Liquan, Wang Cuiyan, Wu Zhiqiang, Yu Xiaoju, Li Weidong, Li Minggang, Oral administration of a fusion protein containing eight GLP-1 analogues produced in Escherichia coli BL21(DE3) in streptozotocin-induced diabetic rats, Biotechnology Letters, 29, 10, 2007. Crossref

  10. Verheyen Ellen, Delain-Bioton Lise, van der Wal Steffen, el Morabit Najim, Barendregt Arjan, Hennink Wim E., van Nostrum Cornelus F., Conjugation of Methacrylamide Groups to a Model Protein via a Reducible Linker for Immobilization and Subsequent Triggered Release from Hydrogels, Macromolecular Bioscience, 10, 12, 2010. Crossref

  11. Chow Albert H.L., Tong Henry H.Y., Zheng Ying, Stability Assessment and Formulation Characterization, in Pharmaceutical Sciences Encyclopedia, 2010. Crossref

  12. Berkland Cory, Pollauf Emily, Raman Chandrashekar, Silverman Roshelle, Kim Kyekyoon (Kevin), Pack Daniel W., Macromolecule Release from Monodisperse PLG Microspheres: Control of Release Rates and Investigation of Release Mechanism, Journal of Pharmaceutical Sciences, 96, 5, 2007. Crossref

  13. Morley Paul, Delivery of parathyroid hormone for the treatment of osteoporosis, Expert Opinion on Drug Delivery, 2, 6, 2005. Crossref

  14. McDowell A., McLeod B. J., Rades T., Tucker I. G., Application of pharmaceutical drug delivery for biological control of the common brushtail possum in New Zealand: a review, Wildlife Research, 33, 8, 2006. Crossref

  15. Kim Moon Suk, Seo Kwang Su, Hyun Hoon, Khang Gilson, Cho Sun Hang, Lee Hai Bang, Controlled release of bovine serum albumin using MPEG–PCL diblock copolymers as implantable protein carriers, Journal of Applied Polymer Science, 102, 2, 2006. Crossref

  16. Bayindir Zerrin Sezgin, Yuksel Nilufer, Characterization of niosomes prepared with various nonionic surfactants for paclitaxel oral delivery, Journal of Pharmaceutical Sciences, 99, 4, 2010. Crossref

  17. Filipe Vasco, Hawe Andrea, Jiskoot Wim, Critical Evaluation of Nanoparticle Tracking Analysis (NTA) by NanoSight for the Measurement of Nanoparticles and Protein Aggregates, Pharmaceutical Research, 27, 5, 2010. Crossref

  18. Lapidge Steven J., Eason Charlie T., Humphrys Simon T., A review of chemical, biological and fertility control options for the camel in Australia, The Rangeland Journal, 32, 1, 2010. Crossref

  19. Cetin Meltem, Youn Yu Seok, Capan Yilmaz, Lee Kang Choon, Preparation and Characterization of Salmon Calcitonin–biotin Conjugates, AAPS PharmSciTech, 9, 4, 2008. Crossref

  20. Xue Weiming, Liu Xiudong, Yu Weiting, Ma Xiaojun, Preparation of protein-loaded microspheres with size ⩽10 μm by electrostatic droplet generation technology, Chinese Science Bulletin, 51, 3, 2006. Crossref

  21. Yamazaki Hiroyuki, Miyake Masateru, Kamada Naoki, Nishibayashi Toru, Mukai Tadashi, Odomi Masaaki, Ishida Tatsuhiro, Kiwada Hiroshi, Co-administration of Tacrolimus Suppresses Pharmacokinetic Modulation of Multiple Subcutaneously Administered Human Interferon-alpha in Beagle Dogs, Drug Metabolism and Pharmacokinetics, 25, 2, 2010. Crossref

  22. Porter R., Kissel C., Saunders H., Keck C., Patient and nurse evaluation of recombinant human follicle-stimulating hormone administration methods: comparison of two follitropin injection pens, Current Medical Research and Opinion, 24, 3, 2008. Crossref

  23. Simic Petra, Vukicevic Slobodan, Bone morphogenetic proteins in development and homeostasis of kidney, Cytokine & Growth Factor Reviews, 16, 3, 2005. Crossref

  24. Miedzybrodzki Ryszard, Fortuna Wojciech, Weber-Dabrowska Beata, Gorski Andrzej, Bacterial viruses against viruses pathogenic for man?, Virus Research, 110, 1-2, 2005. Crossref

  25. Katsila Theodora, Siskos Alexandros P., Tamvakopoulos Constantin, Peptide and protein drugs: The study of their metabolism and catabolism by mass spectrometry, Mass Spectrometry Reviews, 31, 1, 2012. Crossref

  26. McDowell A, McLeod BJ, Rades T, Tucker IG, Polymeric nanoparticles as an oral delivery system for biocontrol agents for the brushtail possum (Trichosurus vulpecula), New Zealand Veterinary Journal, 57, 6, 2009. Crossref

  27. Peniche Hazel, Peniche Carlos, Chitosan nanoparticles: a contribution to nanomedicine, Polymer International, 60, 6, 2011. Crossref

  28. Khafagy El-Sayed, Morishita Mariko, Onuki Yoshinori, Takayama Kozo, Current challenges in non-invasive insulin delivery systems: A comparative review, Advanced Drug Delivery Reviews, 59, 15, 2007. Crossref

  29. Li Zhengrong, Chen Jian, Sun Wenqiang, Xu Yuhong, Investigation of archaeosomes as carriers for oral delivery of peptides, Biochemical and Biophysical Research Communications, 394, 2, 2010. Crossref

  30. Tyagi Priyanka, Kumar Amit, Kumar Yougesh, Lahiri Sitanshu S., Synthesis and characterization of poly(HEMA-MAA) hydrogel carrier for oral delivery of insulin, Journal of Applied Polymer Science, 122, 3, 2011. Crossref

  31. Simi Chandroth Kalyad, Emilia Abraham Tholath, Encapsulation of crosslinked subtilisin microcrystals in hydrogel beads for controlled release applications, European Journal of Pharmaceutical Sciences, 32, 1, 2007. Crossref

  32. Rickard Craig, Letter to the Editor, Critical Reviews in Food Science and Nutrition, 50, 1, 2009. Crossref

  33. Kim Moon Suk, Seo Kwang Su, Hyun Hoon, Kim Sun Kyung, Khang Gilson, Lee Hai Bang, Sustained release of bovine serum albumin using implantable wafers prepared by MPEG–PLGA diblock copolymers, International Journal of Pharmaceutics, 304, 1-2, 2005. Crossref

  34. Maroni Alessandra, Zema Lucia, Del Curto Maria Dorly, Foppoli Anastasia, Gazzaniga Andrea, Oral colon delivery of insulin with the aid of functional adjuvants, Advanced Drug Delivery Reviews, 64, 6, 2012. Crossref

  35. Lee Ping I., Li Jian-Xin, Evolution of Oral Controlled Release Dosage Forms, in Oral Controlled Release Formulation Design and Drug Delivery, 2010. Crossref

  36. Graf Anja, Rades Thomas, Hook Sarah M., Oral insulin delivery using nanoparticles based on microemulsions with different structure-types: Optimisation and in vivo evaluation, European Journal of Pharmaceutical Sciences, 37, 1, 2009. Crossref

  37. Takatsuka Shinya, Morita Takahiro, Horikiri Yuji, Yamahara Hiroshi, Saji Hideo, Absorption enhancement of poorly absorbed hydrophilic compounds from various mucosal sites by combination of mucolytic agent and non-ionic surfactant, International Journal of Pharmaceutics, 338, 1-2, 2007. Crossref

  38. Liu Puchun, Dinh Steven, Oral Delivery of Protein/Peptide Therapeutics, in Oral Bioavailability, 2011. Crossref

  39. Wu Sihui, Tao Yi, Zhang Hongliang, Su Zhengquan, Preparation and Characterization of Water-Soluble Chitosan Microparticles Loaded with Insulin Using the Polyelectrolyte Complexation Method, Journal of Nanomaterials, 2011, 2011. Crossref

  40. Jin Cheng-Hao, Chae Su Young, Son Sohee, Kim Tae Hyung, Um Key An, Youn Yu Seok, Lee Seulki, Lee Kang Choon, A new orally available glucagon-like peptide-1 receptor agonist, biotinylated exendin-4, displays improved hypoglycemic effects in db/db mice, Journal of Controlled Release, 133, 3, 2009. Crossref

  41. Cheng Mao-Bo, Wang Jian-Cheng, Li Yu-Hua, Liu Xiao-Yan, Zhang Xuan, Chen Da-Wei, Zhou Shu-Feng, Zhang Qiang, Characterization of water-in-oil microemulsion for oral delivery of earthworm fibrinolytic enzyme, Journal of Controlled Release, 129, 1, 2008. Crossref

  42. Morishita Mariko, Peppas Nicholas A., Is the oral route possible for peptide and protein drug delivery?, Drug Discovery Today, 11, 19-20, 2006. Crossref

  43. Taluja Ajay, Bae You Han, Role of a novel multifunctional excipient poly(ethylene glycol)-block-oligo(vinyl sulfadimethoxine) in controlled release of lysozyme from PLGA microspheres, International Journal of Pharmaceutics, 358, 1-2, 2008. Crossref

  44. Sun Jing, Miller Jonathan M, Beig Avital, Rozen Liat, Amidon Gordon L, Dahan Arik, Mechanistic enhancement of the intestinal absorption of drugs containing the polar guanidino functionality, Expert Opinion on Drug Metabolism & Toxicology, 7, 3, 2011. Crossref

  45. Tomar Lomas K., Tyagi Charu, Lahiri Sitanshu S., Singh Harpal, Poly(PEGDMA-MAA) copolymeric micro and nanoparticles for oral insulin delivery, Polymers for Advanced Technologies, 22, 12, 2011. Crossref

  46. Ma Bin, Yin Chun, Yang Dan, Lin Ge, Effect of structural modification on the gastrointestinal stability and hepatic metabolism of α-aminoxy peptides, Amino Acids, 43, 5, 2012. Crossref

  47. Yao Jin-Feng, Zhou Ning, Lv Yu-Jian, Zhang Ruifeng, Liu Ke-Liang, Xue Ming, Metabolic stability of long-acting luteinizing hormone-releasing hormone antagonists, Amino Acids, 43, 4, 2012. Crossref

  48. Tang Maoxue, Xie Tingting, Cheng Wenke, Qian Lili, Yang Shulin, Yang Daichang, Cui Wentao, Li Kui, A 90-day safety study of genetically modified rice expressing rhIGF-1 protein in C57BL/6J rats, Transgenic Research, 21, 3, 2012. Crossref

  49. Yao Xudong, Bunt Craig, Cornish Jillian, Quek Siew-Young, Wen Jingyuan, Oral Delivery of Lactoferrin: A Review, International Journal of Peptide Research and Therapeutics, 19, 2, 2013. Crossref

  50. Baeriswyl V., Heinis C., Phage selection of cyclic peptide antagonists with increased stability toward intestinal proteases, Protein Engineering Design and Selection, 26, 1, 2013. Crossref

  51. Singh Deependra, Dubey Pooja, Pradhan Madhulika, Singh Manju Rawat, Ceramic nanocarriers: versatile nanosystem for protein and peptide delivery, Expert Opinion on Drug Delivery, 10, 2, 2013. Crossref

  52. Rekha M.R., Sharma Chandra P., Nanoparticle Mediated Oral Delivery of Peptides and Proteins, in Peptide and Protein Delivery, 2011. Crossref

  53. Sonia T.A., Sharma Chandra P., An overview of natural polymers for oral insulin delivery, Drug Discovery Today, 17, 13-14, 2012. Crossref

  54. Moeller Eva Horn, Jorgensen Lene, Alternative routes of administration for systemic delivery of protein pharmaceuticals, Drug Discovery Today: Technologies, 5, 2-3, 2008. Crossref

  55. Rang HP, Dale MM, Ritter JM, Flower RJ, Absorption and distribution of drugs, in Rang &amp Dale's Pharmacology, 2007. Crossref

  56. Honarparvar Bahareh, Makatini Maya M., Pawar Sachin A., Petzold Katja, Soliman Mahmoud E. S., Arvidsson Per I., Sayed Yasien, Govender Thavendran, Maguire Glenn E. M., Kruger Hendrik G., Pentacycloundecane-diol-Based HIV-1 Protease Inhibitors: Biological Screening, 2D NMR, and Molecular Simulation Studies, ChemMedChem, 7, 6, 2012. Crossref

  57. Chin Jungwook, Foyez Mahmud K.A., Kim Sung Eun, Park Kyeongsoon, Byun Youngro, Insight of current technologies for oral delivery of proteins and peptides, Drug Discovery Today: Technologies, 9, 2, 2012. Crossref

  58. Dong Qing-Guang, Zhang Yong, Wang Meng-Shu, Feng Jiao, Zhang Hai-Hong, Wu Yong-Ge, Gu Tie-Jun, Yu Xiang-Hui, Jiang Chun-Lai, Chen Yan, Li Wei, Kong Wei, Improvement of enzymatic stability and intestinal permeability of deuterohemin-peptide conjugates by specific multi-site N-methylation, Amino Acids, 43, 6, 2012. Crossref

  59. Patel Gaurang, Misra Ambikanandan, Oral Delivery of Proteins and Peptides, in Challenges in Delivery of Therapeutic Genomics and Proteomics, 2011. Crossref

  60. Brady Kevin, Webster Rob, Disposition of Biologics, in Current Concepts in Drug Metabolism and Toxicology, 63, 2012. Crossref

  61. Zhang Xiaoyan, Sun Muzhen, Zheng Aiping, Cao Deying, Bi Yunqi, Sun Jianxu, Preparation and characterization of insulin-loaded bioadhesive PLGA nanoparticles for oral administration, European Journal of Pharmaceutical Sciences, 45, 5, 2012. Crossref

  62. Rang H P, Dale M M, Ritter J M, Flower R J, Henderson G, Drug absorption and distribution, in Rang &amp Dale's Pharmacology, 2012. Crossref

  63. Hurkat Pooja, Jain Aviral, Jain Ashish, Shilpi Satish, Gulbake Arvind, Jain Sanjay K., Concanavalin A conjugated biodegradable nanoparticles for oral insulin delivery, Journal of Nanoparticle Research, 14, 11, 2012. Crossref

  64. Jastrzabek Konrad, Bednarek Przemyslaw, Kolesinska Beata, Kaminski Zbigniew J., Bis(4,6-dimethoxy-1,3,5-triazin-2-yl) Ether as Coupling Reagent for Peptide Synthesis, Chemistry & Biodiversity, 10, 5, 2013. Crossref

  65. Kumar Sandeep, Jana Asim K., Dhamija Isha, Maiti Mithu, Chitosan-assisted immobilization of serratiopeptidase on magnetic nanoparticles, characterization and its target delivery, Journal of Drug Targeting, 22, 2, 2014. Crossref

  66. Diao Lei, Meibohm Bernd, Pharmacokinetics and Pharmacokinetic–Pharmacodynamic Correlations of Therapeutic Peptides, Clinical Pharmacokinetics, 52, 10, 2013. Crossref

  67. Karsdal M. A., Henriksen K., Bay-Jensen A. C., Molloy B., Arnold M., John M. R., Byrjalsen I., Azria M., Riis B. J., Qvist P., Christiansen C., Lessons Learned From the Development of Oral Calcitonin: The First Tablet Formulation of a Protein in Phase III Clinical Trials, The Journal of Clinical Pharmacology, 51, 4, 2011. Crossref

  68. Moradi Shayli Varasteh, Mansfeld Friederike M., Toth Istvan, Synthesis and in vitro evaluation of glycosyl derivatives of luteinizing hormone-releasing hormone (LHRH), Bioorganic & Medicinal Chemistry, 21, 14, 2013. Crossref

  69. Jiang Tao, Singh Bijay, Li Hui-Shan, Kim You-Kyoung, Kang Sang-Kee, Nah Jae-Woon, Choi Yun-Jaie, Cho Chong-Su, Targeted oral delivery of BmpB vaccine using porous PLGA microparticles coated with M cell homing peptide-coupled chitosan, Biomaterials, 35, 7, 2014. Crossref

  70. The Scope of Preformulation Studies, in Handbook of Preformulation, 2006. Crossref

  71. Kumar Sandeep, Jana Asim K., Dhamija Isha, Singla Yashpaul, Maiti Mithu, Preparation, characterization and targeted delivery of serratiopeptidase immobilized on amino-functionalized magnetic nanoparticles, European Journal of Pharmaceutics and Biopharmaceutics, 85, 3, 2013. Crossref

  72. Eskandari Sharareh, Varamini Pegah, Toth Istvan, Formulation, characterization and permeability study of nano particles of lipo-endomorphin-1 for oral delivery, Journal of Liposome Research, 23, 4, 2013. Crossref

  73. Renukuntla Jwala, Vadlapudi Aswani Dutt, Patel Ashaben, Boddu Sai H.S., Mitra Ashim K., Approaches for enhancing oral bioavailability of peptides and proteins, International Journal of Pharmaceutics, 447, 1-2, 2013. Crossref

  74. Bandala Yamir, Reyes-Rangel Gloria, Obregón-Zúñiga Arturo, Cruz-Hernández Carlos, Corzo Gerardo, Juaristi Eusebio, trans-Hexahydrobenzoxazolidinones in the Enantioselective Synthesis of β2-Amino Acids Containing Proteinogenic Side Chains, European Journal of Organic Chemistry, 2014, 11, 2014. Crossref

  75. Caon Thiago, Jin Liang, Simões Cláudia M. O., Norton Raymond S., Nicolazzo Joseph A., Enhancing the Buccal Mucosal Delivery of Peptide and Protein Therapeutics, Pharmaceutical Research, 32, 1, 2015. Crossref

  76. Muheem Abdul, Shakeel Faiyaz, Jahangir Mohammad Asadullah, Anwar Mohammed, Mallick Neha, Jain Gaurav Kumar, Warsi Musarrat Husain, Ahmad Farhan Jalees, A review on the strategies for oral delivery of proteins and peptides and their clinical perspectives, Saudi Pharmaceutical Journal, 24, 4, 2016. Crossref

  77. Song Zuowei, Zhang Mengyao, Xue Renyu, Cao Guangli, Gong Chengliang, Reducing blood glucose levels in TIDM mice with an orally administered extract of sericin from hIGF-I-transgenic silkworm cocoons, Food and Chemical Toxicology, 67, 2014. Crossref

  78. Bagul Pravin, Khomane Kailas S., Kesharwani Siddharth S., Pragyan Preeti, Nandekar Prajwal P., Meena Chhuttan Lal, Bansal Arvind K., Jain Rahul, Tikoo Kulbhushan, Sangamwar Abhay T., Intestinal transport of TRH analogs through PepT1: the role ofin silicoandin vitromodeling, Journal of Molecular Recognition, 27, 10, 2014. Crossref

  79. Parmentier Johannes, Hofhaus Götz, Thomas Silke, Cuesta Laura Clusa, Gropp Felix, Schröder Rasmus, Hartmann Klaus, Fricker Gert, Improved Oral Bioavailability of Human Growth Hormone by a Combination of Liposomes Containing Bio-Enhancers and Tetraether Lipids and Omeprazole, Journal of Pharmaceutical Sciences, 103, 12, 2014. Crossref

  80. Farahani Majid D., Honarparvar Bahareh, Albericio Fernando, Maguire Glenn E. M., Govender Thavendran, Arvidsson Per I., Kruger Hendrik G., Proline N-oxides: modulators of the 3D conformation of linear peptides through “NO-turns”, Organic & Biomolecular Chemistry, 12, 25, 2014. Crossref

  81. Lv Peng-Cheng, Zhu Hai-Liang, EGFR-binding peptide: a patent evaluation of WO2014002836, Expert Opinion on Therapeutic Patents, 24, 12, 2014. Crossref

  82. Tuvia Shmuel, Pelled Dori, Marom Karen, Salama Paul, Levin-Arama Maya, Karmeli Irina, Idelson Gregory H., Landau Isaac, Mamluk Roni, A Novel Suspension Formulation Enhances Intestinal Absorption of Macromolecules Via Transient and Reversible Transport Mechanisms, Pharmaceutical Research, 31, 8, 2014. Crossref

  83. Müller Christiane, Bernkop-Schnürch Andreas, Thiomers, in Mucoadhesive Materials and Drug Delivery Systems, 2014. Crossref

  84. Di Li, Strategic Approaches to Optimizing Peptide ADME Properties, The AAPS Journal, 17, 1, 2015. Crossref

  85. Ibraheem D., Elaissari A., Fessi H., Administration strategies for proteins and peptides, International Journal of Pharmaceutics, 477, 1-2, 2014. Crossref

  86. Kumar Sandeep, Jana Asim K., Maiti Mithu, Dhamija Isha, Carbodiimide-mediated immobilization of serratiopeptidase on amino-, carboxyl-functionalized magnetic nanoparticles and characterization for target delivery, Journal of Nanoparticle Research, 16, 2, 2014. Crossref

  87. Saleh Ahmed S. M., Zhang Qing, Shen Qun, Recent Research in Antihypertensive Activity of Food Protein-derived Hydrolyzates and Peptides, Critical Reviews in Food Science and Nutrition, 56, 5, 2016. Crossref

  88. Inchaurraga Laura, Martín-Arbella Nekane, Zabaleta Virginia, Quincoces Gemma, Peñuelas Ivan, Irache Juan M., In vivo study of the mucus-permeating properties of PEG-coated nanoparticles following oral administration, European Journal of Pharmaceutics and Biopharmaceutics, 97, 2015. Crossref

  89. Sonia Thundiparambil Azeez, Sharma Chandra P., Polymers in oral insulin delivery, in Oral Delivery of Insulin, 2014. Crossref

  90. Sonia Thundiparambil Azeez, Sharma Chandra P., Summary and future perspectives for oral insulin delivery, in Oral Delivery of Insulin, 2014. Crossref

  91. Sonia Thundiparambil Azeez, Sharma Chandra P., Oral insulin delivery – challenges and strategies, in Oral Delivery of Insulin, 2014. Crossref

  92. Lennernäs Hans, Abrahamsson Bertil, The use of biopharmaceutic classification of drugs in drug discovery and development: current status and future extension, Journal of Pharmacy and Pharmacology, 57, 3, 2010. Crossref

  93. Ibañez Andrés Esteban, Coria Lorena Mirta, Carabajal Marianela Verónica, Delpino María Victoria, Risso Gabriela Sofía, Cobiello Paula Gonzalez, Rinaldi Jimena, Barrionuevo Paula, Bruno Laura, Frank Fernanda, Klinke Sebastián, Goldbaum Fernando Alberto, Briones Gabriel, Giambartolomei Guillermo Hernán, Pasquevich Karina Alejandra, Cassataro Juliana, A bacterial protease inhibitor protects antigens delivered in oral vaccines from digestion while triggering specific mucosal immune responses, Journal of Controlled Release, 220, 2015. Crossref

  94. Karsdal Morten Asser, Riis Bente Juul, Mehta Nozer, Stern William, Arbit Ehud, Christiansen Claus, Henriksen Kim, Lessons learned from the clinical development of oral peptides, British Journal of Clinical Pharmacology, 79, 5, 2015. Crossref

  95. Lennernäs H., Abrahamsson B., The Biopharmaceutics Classification System, in Comprehensive Medicinal Chemistry II, 2007. Crossref

  96. Truong-Le Vu, Lovalenti Phillip M., Abdul-Fattah Ahmad M., Stabilization Challenges and Formulation Strategies Associated with Oral Biologic Drug Delivery Systems, Advanced Drug Delivery Reviews, 93, 2015. Crossref

  97. Alakhov Valery, Pietrzynski Grzegorz, Patel Kishore, Kabanov Alexander, Bromberg Lev, Hatton T Alan, Pluronic block copolymers and Pluronic poly(acrylic acid) microgels in oral delivery of megestrol acetate, Journal of Pharmacy and Pharmacology, 56, 10, 2010. Crossref

  98. Tessaro Irene, Modina Silvia C., Franciosi Federica, Sivelli Giulia, Terzaghi Laura, Lodde Valentina, Luciano Alberto M., Effect of oral administration of low-dose follicle stimulating hormone on hyperandrogenized mice as a model of polycystic ovary syndrome, Journal of Ovarian Research, 8, 1, 2015. Crossref

  99. Maher Sam, Mrsny Randall J., Brayden David J., Intestinal permeation enhancers for oral peptide delivery, Advanced Drug Delivery Reviews, 106, 2016. Crossref

  100. Niu Zhigao, Conejos-Sánchez Inmaculada, Griffin Brendan T., O’Driscoll Caitriona M., Alonso María J., Lipid-based nanocarriers for oral peptide delivery, Advanced Drug Delivery Reviews, 106, 2016. Crossref

  101. Sachdeva Sakshi, Peptides as ‘Drugs’: The Journey so Far, International Journal of Peptide Research and Therapeutics, 23, 1, 2017. Crossref

  102. Fouché Marianne, Schäfer Michael, Blatter Markus, Berghausen Jörg, Desrayaud Sandrine, Roth Hans-Jörg, Pharmacokinetic Studies around the Mono- and Difunctionalization of a Bioavailable Cyclic Decapeptide Scaffold, ChemMedChem, 11, 10, 2016. Crossref

  103. Moradi Shayli Varasteh, Hussein Waleed M., Varamini Pegah, Simerska Pavla, Toth Istvan, Glycosylation, an effective synthetic strategy to improve the bioavailability of therapeutic peptides, Chemical Science, 7, 4, 2016. Crossref

  104. Peptide-Mediated Nanoparticle Drug Delivery System, in Nanotechnology in Drug Delivery, 2016. Crossref

  105. Bourganis Vassilis, Karamanidou Theodora, Kammona Olga, Kiparissides Costas, Polyelectrolyte complexes as prospective carriers for the oral delivery of protein therapeutics, European Journal of Pharmaceutics and Biopharmaceutics, 111, 2017. Crossref

  106. Pérez Yolanda, Urista Claudia, Martínez Javier, Nava María, Rodríguez Francisco, Functionalized Polymers for Enhance Oral Bioavailability of Sensitive Molecules, Polymers, 8, 6, 2016. Crossref

  107. Guha Arijit, Biswas Nikhil, Bhattacharjee Kaustav, Sahoo Nityananda, Kuotsu Ketousetuo, pH responsive cylindrical MSN for oral delivery of insulin-design, fabrication and evaluation, Drug Delivery, 23, 9, 2016. Crossref

  108. Smythe M.L., Orally Delivered Peptides for Treatment of Inflammatory Bowel Disease, in Comprehensive Medicinal Chemistry III, 2017. Crossref

  109. GAO YAN-FANG, WEI XUE-NI, YE XIAO-LEI, WENG GUO-BIN, CHEN YI-CHEN, ZHAO YA-RONG, JI HUI, Anticancer activity of stoppin based on a novel peptide delivery system, Molecular Medicine Reports, 12, 4, 2015. Crossref

  110. Zhu Siqi, Chen Shuangxi, Gao Yuan, Guo Feng, Li Fengying, Xie Baogang, Zhou Jianliang, Zhong Haijun, Enhanced oral bioavailability of insulin using PLGA nanoparticles co-modified with cell-penetrating peptides and Engrailed secretion peptide (Sec), Drug Delivery, 23, 6, 2016. Crossref

  111. Zakeri Siavashani Abdollah, Haghbin Nazarpak Masoumeh, Fayyazbakhsh Fateme, Toliyat Tayebeh, McInnes Steven James Peter, Solati-Hashjin Mehran, Effect of amino-functionalization on insulin delivery and cell viability for two types of silica mesoporous structures, Journal of Materials Science, 51, 24, 2016. Crossref

  112. Hecq J., Amighi K., Goole J., Development and evaluation of insulin-loaded cationic solid lipid nanoparticles for oral delivery, Journal of Drug Delivery Science and Technology, 36, 2016. Crossref

  113. Jin Liang, Zhou Qi (Tony), Chan Hak-Kim, Larson Ian C., Pennington Michael W., Morales Rodrigo A.V., Boyd Ben J., Norton Raymond S., Nicolazzo Joseph A., Pulmonary Delivery of the Kv1.3-Blocking Peptide HsTX1[R14A] for the Treatment of Autoimmune Diseases, Journal of Pharmaceutical Sciences, 105, 2, 2016. Crossref

  114. Nurunnabi Md, Khatun Zehedina, Revuri Vishnu, Nafiujjaman Md, Cha Seungbin, Cho Sungpil, Moo Huh Kang, Lee Yong-kyu, Design and strategies for bile acid mediated therapy and imaging, RSC Advances, 6, 78, 2016. Crossref

  115. Fouché Marianne, Schäfer Michael, Berghausen Jörg, Desrayaud Sandrine, Blatter Markus, Piéchon Philippe, Dix Ina, Martin Garcia Aimar, Roth Hans-Jörg, Design and Development of a Cyclic Decapeptide Scaffold with Suitable Properties for Bioavailability and Oral Exposure, ChemMedChem, 11, 10, 2016. Crossref

  116. Yadav Vipul, Varum Felipe, Bravo Roberto, Furrer Esther, Basit Abdul W., Gastrointestinal stability of therapeutic anti-TNF α IgG1 monoclonal antibodies, International Journal of Pharmaceutics, 502, 1-2, 2016. Crossref

  117. Shi Guorong, Liu Yating, He Zijun, Zhou Jihen, Chemical treatment and chitosan coating of yeast cells to improve the encapsulation and controlled release of bovine serum albumin, Artificial Cells, Nanomedicine, and Biotechnology, 45, 6, 2017. Crossref

  118. Van Eyk A.D., Van Der Bijl P., Moll L.M., Physicochemical Characteristics of Molecules and Their Diffusion across Human Vaginal Mucosa, European Journal of Inflammation, 6, 2, 2008. Crossref

  119. Norton Raymond S., Enhancing the therapeutic potential of peptide toxins, Expert Opinion on Drug Discovery, 12, 6, 2017. Crossref

  120. Shenmar Kitika, Sharma Krishna K., Wangoo Nishima, Maurya Indresh K., Kumar Vinod, Khan Shabana I., Jacob Melissa R., Tikoo Kulbhushan, Jain Rahul, Synthesis, stability and mechanistic studies of potent anticryptococcal hexapeptides, European Journal of Medicinal Chemistry, 132, 2017. Crossref

  121. Cui Yi, Shan Wei, Liu Min, Wu Lei, Huang Yuan, A strategy for developing effective orally-delivered nanoparticles through modulation of the surface “hydrophilicity/hydrophobicity balance”, Journal of Materials Chemistry B, 5, 6, 2017. Crossref

  122. Liu Xin, Zheng Sidi, Qin Yue, Ding Wenya, Tu Yabin, Chen Xingru, Wu Yunzhou, Yanhua Li, Cai Xuehui, Experimental Evaluation of the Transport Mechanisms of PoIFN-α in Caco-2 Cells, Frontiers in Pharmacology, 8, 2017. Crossref

  123. Maiti Sabyasachi, Nanometric Biopolymer Devices for Oral Delivery of Macromolecules with Clinical Significance, in Multifunctional Systems for Combined Delivery, Biosensing and Diagnostics, 2017. Crossref

  124. Khatri Pulkit, Shao Jun, Transport of lipid nano-droplets through MDCK epithelial cell monolayer, Colloids and Surfaces B: Biointerfaces, 153, 2017. Crossref

  125. Berardi Alberto, Lomonossoff George P., Evans David J., Barker Susan A., Plant-expressed Hepatitis B core antigen virus-like particles: Characterization and investigation of their stability in simulated and pig gastro-intestinal fluids, International Journal of Pharmaceutics, 522, 1-2, 2017. Crossref

  126. Gedawy Ahmed, Martinez Jorge, Al-Salami Hani, Dass Crispin R, Oral insulin delivery: existing barriers and current counter-strategies, Journal of Pharmacy and Pharmacology, 70, 2, 2018. Crossref

  127. Nawaz K.A. Ayub, David Swapna Merlin, Murugesh Easwaran, Thandeeswaran Murugesan, Kiran Kalarikkal Gopikrishnan, Mahendran Ramasamy, Palaniswamy Muthusamy, Angayarkanni Jayaraman, Identification and in silico characterization of a novel peptide inhibitor of angiotensin converting enzyme from pigeon pea ( Cajanus cajan ), Phytomedicine, 36, 2017. Crossref

  128. Sai Wenbo, Tian Hong, Yang Kangmin, Tang Daoqi, Bao Jinxiao, Ge Yang, Song Xiaoda, Zhang Yu, Luo Cheng, Gao Xiangdong, Yao Wenbing, Systematic Design of Trypsin Cleavage Site Mutated Exendin4-Cysteine 1, an Orally Bioavailable Glucagon-Like Peptide-1 Receptor Agonist, International Journal of Molecular Sciences, 18, 3, 2017. Crossref

  129. Pasquevich María Yanina, Dreon Marcos Sebastián, Qiu Jian-Wen, Mu Huawei, Heras Horacio, Convergent evolution of plant and animal embryo defences by hyperstable non-digestible storage proteins, Scientific Reports, 7, 1, 2017. Crossref

  130. Vela Ramirez Julia E., Sharpe Lindsey A., Peppas Nicholas A., Current state and challenges in developing oral vaccines, Advanced Drug Delivery Reviews, 114, 2017. Crossref

  131. Araújo Francisca, Fonte Pedro, Santos Hélder A., Sarmento Bruno, Oral Delivery of Glucagon-like Peptide-1 and Analogs: Alternatives for Diabetes Control?, Journal of Diabetes Science and Technology, 6, 6, 2012. Crossref

  132. Gupta Vivek, Doshi Nishit, Mitragotri Samir, Coles Jonathan A., Permeation of Insulin, Calcitonin and Exenatide across Caco-2 Monolayers: Measurement Using a Rapid, 3-Day System, PLoS ONE, 8, 2, 2013. Crossref

  133. Sakai-Kato Kumiko, Nanjo Kunie, Goda Yukihiro, Rapid Analysis of Cyclic Peptide Cyclosporine A by HPLC Using a Column Packed with Nonporous Particles, Chemical and Pharmaceutical Bulletin, 66, 8, 2018. Crossref

  134. Mohamed Mohamed Y H, Christie Graham, A system for the expression and release of heterologous proteins from the core ofBacillus subtilisspores, FEMS Microbiology Letters, 365, 23, 2018. Crossref

  135. Sangsawad Papungkorn, Choowongkomon Kiattawee, Kitts David D., Chen Xiu-Min, Li-Chan Eunice C.Y., Yongsawatdigul Jirawat, Transepithelial transport and structural changes of chicken angiotensin I-converting enzyme (ACE) inhibitory peptides through Caco-2 cell monolayers, Journal of Functional Foods, 45, 2018. Crossref

  136. Räder Andreas F. B., Weinmüller Michael, Reichart Florian, Schumacher-Klinger Adi, Merzbach Shira, Gilon Chaim, Hoffman Amnon, Kessler Horst, Orally Active Peptides: Is There a Magic Bullet?, Angewandte Chemie International Edition, 57, 44, 2018. Crossref

  137. Coria Lorena M., Risso Gabriela S., Guaimas Francisco F., Ferrero Mariana C., Bruno Laura, Pasquevich Karina A., Cassataro Juliana, Oral co-administration of a bacterial protease inhibitor in the vaccine formulation increases antigen delivery at the intestinal epithelial barrier, Journal of Controlled Release, 293, 2019. Crossref

  138. Räder Andreas F. B., Weinmüller Michael, Reichart Florian, Schumacher-Klinger Adi, Merzbach Shira, Gilon Chaim, Hoffman Amnon, Kessler Horst, Oral aktive Peptide: Gibt es ein Patentrezept?, Angewandte Chemie, 130, 44, 2018. Crossref

  139. Wang X.N., Wang L., Zheng D.Z., Chen S., Shi W., Qiao X.Y., Jiang Y.P., Tang L.J., Xu Y.G., Li Y.J., Oral immunization with aLactobacillus casei-based anti-porcine epidemic diarrhoea virus (PEDV) vaccine expressing microfold cell-targeting peptide Co1 fused with the COE antigen of PEDV, Journal of Applied Microbiology, 124, 2, 2018. Crossref

  140. Gourdon Betty, Chemin Caroline, Moreau Amélie, Arnauld Thomas, Delbos Jean-Marie, Péan Jean-Manuel, Declèves Xavier, Influence of PLA-PEG nanoparticles manufacturing process on intestinal transporter PepT1 targeting and oxytocin transport, European Journal of Pharmaceutics and Biopharmaceutics, 129, 2018. Crossref

  141. Vllasaliu Driton, Thanou Maya, Stolnik Snjezana, Fowler Robyn, Recent advances in oral delivery of biologics: nanomedicine and physical modes of delivery, Expert Opinion on Drug Delivery, 15, 8, 2018. Crossref

  142. Granhall Charlotte, Søndergaard Flemming L., Thomsen Mette, Anderson Thomas W., Pharmacokinetics, Safety and Tolerability of Oral Semaglutide in Subjects with Renal Impairment, Clinical Pharmacokinetics, 57, 12, 2018. Crossref

  143. Szloszár Aliz, Mándity István M., Fülöp Ferenc, Sustainable synthesis of N-methylated peptides in a continuous-flow fixed bed reactor, Journal of Flow Chemistry, 8, 1, 2018. Crossref

  144. Sroka Thomas C., Cress Anne E., Lam Kit S., EPITHELIAL CELL SURFACE TARGETING USING SYNTHETIC D-AMINO ACID PEPTIDES, in Cell Adhesion and Cytoskeletal Molecules in Metastasis, 9, 2006. Crossref

  145. Özyazıcı Mine, Gökçe Evren Homan, Yurdasiper Aysu, Nanosized Drug Delivery for Enhancement of Oral Bioavailability, in Patenting Nanomedicines, 2012. Crossref

  146. Zermeño‐Cervantes Lina Angélica, González‐Acosta Bárbara, Martínez‐Díaz Sergio Francisco, Cardona‐Félix César Salvador, Antibacterial proteins and peptides as potential treatment in aquaculture: current status and perspectives on delivery, Reviews in Aquaculture, 12, 2, 2020. Crossref

  147. Ruiz Sara Melisa Arciniegas, Bernad Bernad María Josefa, Arellano Raquel Lopez, Torres Roberto Diaz, Del Carmen Caballero Chacón Sara, Estrada Dinorah Vargas, In Vitro and In Vivo Profiles and Characterization of Insulin Nanocarriers Based in Flexible Liposomes Designed for Oral Administration, Letters in Drug Design & Discovery, 16, 8, 2019. Crossref

  148. Wilkhu Jitinder S., Perrie Yvonne, Developing Bilayer-Based Delivery Systems for Oral Delivery of Subunit Vaccines, in Subunit Vaccine Delivery, 2015. Crossref

  149. Meibohm Bernd, Pharmacokinetics and Pharmacodynamics of Therapeutic Peptides and Proteins, in Pharmaceutical Biotechnology, 2019. Crossref

  150. Lalatsa Aikaterini, Peptides, Proteins and Antibodies, in Fundamentals of Pharmaceutical Nanoscience, 2013. Crossref

  151. Thotakura Nagarani, Kaushik Lokesh, Kumar Vipin, Preet Simran, Babu Penke Vijaya, Advanced Approaches of Bioactive Peptide Molecules and Protein Drug Delivery Systems, Current Pharmaceutical Design, 24, 43, 2019. Crossref

  152. Deb Pran Kishore, Al-Attraqchi Omar, Chandrasekaran Balakumar, Paradkar Anant, Tekade Rakesh K., Protein/Peptide Drug Delivery Systems, in Basic Fundamentals of Drug Delivery, 2019. Crossref

  153. Ribeiro Antonio J., Seiça Raquel, Veiga Francisco, Nanoparticles for Oral Delivery of Insulin, in Drug Delivery Systems: Advanced Technologies Potentially Applicable in Personalised Treatment, 4, 2013. Crossref

  154. Guo Feng, Ouyang Ting, Peng Taoxing, Zhang Xiuying, Xie Baogang, Yang Xiaoling, Liang Desheng, Zhong Haijun, Enhanced oral absorption of insulin using colon-specific nanoparticles co-modified with amphiphilic chitosan derivatives and cell-penetrating peptides, Biomaterials Science, 7, 4, 2019. Crossref

  155. Wang Kai, Su Yu, Liang Yuting, Song Yanhui, Wang Liping, Oral DhHP-6 for the Treatment of Type 2 Diabetes Mellitus, International Journal of Molecular Sciences, 20, 6, 2019. Crossref

  156. Haasbroek Anja, Willers Clarissa, Glyn Matthew, du Plessis Lissinda, Hamman Josias, Intestinal Drug Absorption Enhancement by Aloe vera Gel and Whole Leaf Extract: In Vitro Investigations into the Mechanisms of Action, Pharmaceutics, 11, 1, 2019. Crossref

  157. Efiana Nuri Ari, Dizdarević Aida, Huck Christian W., Bernkop-Schnürch Andreas, Improved Intestinal Mucus Permeation of Vancomycin via Incorporation Into Nanocarrier Containing Papain-Palmitate, Journal of Pharmaceutical Sciences, 108, 10, 2019. Crossref

  158. Cao Shu-jun, Xu Shuo, Wang Hui-ming, Ling Yong, Dong Jiahua, Xia Rui-dong, Sun Xiang-hong, Nanoparticles: Oral Delivery for Protein and Peptide Drugs, AAPS PharmSciTech, 20, 5, 2019. Crossref

  159. Ibrahim Yousif H-E. Y., Regdon Géza, Hamedelniel Elnazeer I., Sovány Tamás, Review of recently used techniques and materials to improve the efficiency of orally administered proteins/peptides, DARU Journal of Pharmaceutical Sciences, 28, 1, 2020. Crossref

  160. Shukla Rahul, Vender Ronald B., Pharmacology of TNF inhibitors, in TNF-alpha Inhibitors, 2006. Crossref

  161. Sharma Jatin, Larkin Joseph, Therapeutic Implication of SOCS1 Modulation in the Treatment of Autoimmunity and Cancer, Frontiers in Pharmacology, 10, 2019. Crossref

  162. Hong Hui, Fan Hongbing, Chalamaiah Meram, Wu Jianping, Preparation of low-molecular-weight, collagen hydrolysates (peptides): Current progress, challenges, and future perspectives, Food Chemistry, 301, 2019. Crossref

  163. Zhao Shengnan, Li Jinhua, Wang Fazhan, Yu Ting, Zhou Yang, He Lili, Zhang Yi, Yang Jian, Semi-elastic core-shell nanoparticles enhanced the oral bioavailability of peptide drugs, Chinese Chemical Letters, 31, 5, 2020. Crossref

  164. Ribeiro Rita, Abreu Teresa Raquel, Silva Ana Catarina, Gonçalves João, Moreira João Nuno, Insights on the Formulation of Recombinant Proteins, in Current Applications of Pharmaceutical Biotechnology, 171, 2019. Crossref

  165. Nielsen Hanne Mørck, Epithelial Permeation and Absorption Mechanisms of Biopharmaceuticals, in Mucosal Delivery of Biopharmaceuticals, 2014. Crossref

  166. Meibohm Bernd, Pharmacokinetics and Pharmacodynamics of Peptide and Protein Therapeutics, in Pharmaceutical Biotechnology, 2013. Crossref

  167. Batista Patrícia, Castro Pedro, Madureira Ana, Sarmento Bruno, Pintado Manuela, Development and Characterization of Chitosan Microparticles-in-Films for Buccal Delivery of Bioactive Peptides, Pharmaceuticals, 12, 1, 2019. Crossref

  168. Yadav Krishna, Chauhan Nagendra Singh, Saraf Swarnlata, Singh Deependra, Singh Manju Rawat, Challenges and need of delivery carriers for bioactives and biological agents: an introduction, in Advances and Avenues in the Development of Novel Carriers for Bioactives and Biological Agents, 2020. Crossref

  169. Khaleel Basha S., Syed Muzammil M., Dhandayuthabani R., Sugantha Kumari V., Development of nanoemulsion of Alginate/Aloe vera for oral delivery of insulin, Materials Today: Proceedings, 36, 2021. Crossref

  170. Rasmussen Mads Frederik, The development of oral semaglutide, an oral GLP-1 analog, for the treatment of type 2 diabetes, Diabetology International, 11, 2, 2020. Crossref

  171. Zhang Zhentao, Tian Ye, Ye Keqiang, δ-secretase in neurodegenerative diseases: mechanisms, regulators and therapeutic opportunities, Translational Neurodegeneration, 9, 1, 2020. Crossref

  172. Oral Delivery Systems, in Biodrug Delivery Systems, 2016. Crossref

  173. Dan Nirnoy, Samanta Kamalika, Almoazen Hassan, An Update on Pharmaceutical Strategies for Oral Delivery of Therapeutic Peptides and Proteins in Adults and Pediatrics, Children, 7, 12, 2020. Crossref

  174. Günday Türeli Nazende, Türeli Akif Emre, Industrial perspectives and future of oral drug delivery, in Nanotechnology for Oral Drug Delivery, 2020. Crossref

  175. Raghuwanshi Sanjeev, Agarwal Rashi, Raval Ritu, Gutti Ravi Kumar, Chitosan Nanoparticles and Their Applications in Drug Delivery, Hemostasis, and Stem Cell Research, in Functional Bionanomaterials, 2020. Crossref

  176. Amigo Lourdes, Hernández-Ledesma Blanca, Current Evidence on the Bioavailability of Food Bioactive Peptides, Molecules, 25, 19, 2020. Crossref

  177. Pretorius Elizca, Willers Clarissa, Hamman Josias H., Steyn Johan D., Gastrointestinal Region Specific Insulin Permeation Enhancement by Aloe vera Gel, Drug Delivery Letters, 10, 2, 2020. Crossref

  178. Arciniegas Sara Melisa, Saavedra Sergio Andres, Balderas Danaé, del Carmen Caballero Sara, Bernad María Josefa, Sánchez Julio Cesar, Gracia María Isabel, Rico Héctor Ariel, Vargas Dinorah, Comparison in the Glucose Response of Flexible Liposomes Loaded with Insulin with the Addition of Different Surfactants in an Experimental Diabetes Model, Letters in Drug Design & Discovery, 17, 6, 2020. Crossref

  179. Tong Tong, Wang Liying, You Xinru, Wu Jun, Nano and microscale delivery platforms for enhanced oral peptide/protein bioavailability, Biomaterials Science, 8, 21, 2020. Crossref

  180. Marušić Maja, Zupančič Tina, Hribar Gorazd, Komel Radovan, Anderluh Gregor, Caserman Simon, The Caco-2 cell culture model enables sensitive detection of enhanced protein permeability in the presence of N-decyl-β-d-maltopyranoside, New Biotechnology, 30, 5, 2013. Crossref

  181. Shinde Priyanka, Badgujar Hina F., Kumar Umesh, Strategies to Improve Oral Delivery of Natural Anticancer Molecules, in Emerging Trends in Nanomedicine, 2021. Crossref

  182. Bruno Benjamin J, Miller Geoffrey D, Lim Carol S, Basics and recent advances in peptide and protein drug delivery, Therapeutic Delivery, 4, 11, 2013. Crossref

  183. Ellert-Miklaszewska Aleksandra, Poleszak Katarzyna, Kaminska Bozena, Short peptides interfering with signaling pathways as new therapeutic tools for cancer treatment, Future Medicinal Chemistry, 9, 2, 2017. Crossref

  184. Overgaard Rune V., Navarria Andrea, Ingwersen Steen H., Bækdal Tine A., Kildemoes Rasmus Juul, Clinical Pharmacokinetics of Oral Semaglutide: Analyses of Data from Clinical Pharmacology Trials, Clinical Pharmacokinetics, 60, 10, 2021. Crossref

  185. Delfi Masoud, Sartorius Rossella, Ashrafizadeh Milad, Sharifi Esmaeel, Zhang Yapei, De Berardinis Piergiuseppe, Zarrabi Ali, Varma Rajender S., Tay Franklin R., Smith Bryan Ronain, Makvandi Pooyan, Self-assembled peptide and protein nanostructures for anti-cancer therapy: Targeted delivery, stimuli-responsive devices and immunotherapy, Nano Today, 38, 2021. Crossref

  186. Narayanan Deepa, Anitha A., Jayakumar R., Chennazhi K. P., In Vitro and in Vivo Evaluation of Osteoporosis Therapeutic Peptide PTH 1–34 Loaded PEGylated Chitosan Nanoparticles, Molecular Pharmaceutics, 10, 11, 2013. Crossref

  187. Xu Zhe, Chen Hui, Fan Fengjiao, Shi Pujie, Cheng Shuzhen, Tu Maolin, Ei-Seedi Hesham R., Du Ming, Pharmacokinetics and Transport of an Osteogenic Dodecapeptide, Journal of Agricultural and Food Chemistry, 68, 37, 2020. Crossref

  188. Griffin BT, O’Driscoll CM, Opportunities and challenges for oral delivery of hydrophobic versus hydrophilic peptide and protein-like drugs using lipid-based technologies, Therapeutic Delivery, 2, 12, 2011. Crossref

  189. Khomane Kailas S., Nandekar Prajwal P., Wahlang Banrida, Bagul Pravin, Shaikh Naeem, Pawar Yogesh B., Meena Chhuttan Lal, Sangamwar Abhay T., Jain Rahul, Tikoo K., Bansal Arvind K., Mechanistic Insights into PEPT1-Mediated Transport of a Novel Antiepileptic, NP-647, Molecular Pharmaceutics, 9, 9, 2012. Crossref

  190. Pinto Reis Catarina, Silva Catarina, Martinho Nuno, Rosado Catarina, Drug carriers for oral delivery of peptides and proteins: accomplishments and future perspectives, Therapeutic Delivery, 4, 2, 2013. Crossref

  191. Gohil Dipti, Thirugnanasambandan Theivasanthi, Nanocarriers in Protein and Peptide Drug Delivery, in Nanocarriers: Drug Delivery System, 2021. Crossref

  192. Navarro Sara M, Darensbourg Caleb, Cross Linda, Stout Rhett, Coulon Diana, Astete Carlos E, Morgan Timothy, Sabliov Cristina M, Biodistribution of PLGA and PLGA/chitosan nanoparticles after repeat-dose oral delivery in F344 rats for 7 days, Therapeutic Delivery, 5, 11, 2014. Crossref

  193. Lau Ching Ching, Abdullah Noorlidah, Shuib Adawiyah Suriza, Novel angiotensin I-converting enzyme inhibitory peptides derived from an edible mushroom, Pleurotus cystidiosus O.K. Miller identified by LC-MS/MS, BMC Complementary and Alternative Medicine, 13, 1, 2013. Crossref

  194. Modi Nishit B., Cheng Xiaoli, Mattheakis Larry, Hwang Ching‐Chang, Nawabi Roya, Liu David, Gupta Suneel, Single‐ and Multiple‐Dose Pharmacokinetics and Pharmacodynamics of PN‐943, a Gastrointestinal‐Restricted Oral Peptide Antagonist of α4β7, in Healthy Volunteers, Clinical Pharmacology in Drug Development, 10, 11, 2021. Crossref

  195. Yeo JuDong, Shahidi Fereidoon, Bioactive peptides in health and disease: an overview, in Biologically Active Peptides, 2021. Crossref

  196. Li Caroline M., Haratipour Pouya, Lingeman Robert G., Perry J. Jefferson P., Gu Long, Hickey Robert J., Malkas Linda H., Novel Peptide Therapeutic Approaches for Cancer Treatment, Cells, 10, 11, 2021. Crossref

  197. Kaklotar Dhansukh, Agrawal Poornima, Abdulla Allabakshi, Singh Rahul P, Mehata Abhishesh K, Singh Sanjay, Mishra Brahmeshwar, Pandey Bajarangprasad L, Trigunayat Anshuman, Muthu Madaswamy S, Transition from passive to active targeting of oral insulin nanomedicines: enhancement in bioavailability and glycemic control in diabetes, Nanomedicine, 11, 11, 2016. Crossref

  198. Ahangarpour Marzieh, Kavianinia Iman, Harris Paul W. R., Brimble Margaret A., Photo-induced radical thiol–ene chemistry: a versatile toolbox for peptide-based drug design, Chemical Society Reviews, 50, 2, 2021. Crossref

  199. Utsunomiya Takafumi, Tanaka Atsushi, Tatsumi Kenichi, Ezcurra Diego, A questionnaire-based survey to assess patient satisfaction, ease-of-learning, ease-of-use, injection site pain and overall patient satisfaction of the follitropin-alpha (Gonal-f) filled-by-mass (FbM) prefilled pen compared with other systems of gonadotrophin administration, Reproductive Biology and Endocrinology, 10, 1, 2012. Crossref

  200. Xue Renyu, Wang Yang, Cao Guangli, Pan Zhonghua, Zheng Xiaojian, Zhou Wenlin, Gong Chengliang, Lowering the Blood Glucose of Diabetes Mellitus Mice by Oral Administration with Transgenic Human Insulin-like Growth Factor I Silkworms, Journal of Agricultural and Food Chemistry, 60, 26, 2012. Crossref

  201. Kósa Dóra, Pető Ágota, Fenyvesi Ferenc, Váradi Judit, Vecsernyés Miklós, Budai István, Németh József, Fehér Pálma, Bácskay Ildikó, Ujhelyi Zoltán, Oral Bioavailability Enhancement of Melanin Concentrating Hormone, Development and In Vitro Pharmaceutical Assessment of Novel Delivery Systems, Pharmaceutics, 14, 1, 2021. Crossref

  202. Wang Jie, Yadav Vipul, Smart Alice L., Tajiri Shinichiro, Basit Abdul W., Toward Oral Delivery of Biopharmaceuticals: An Assessment of the Gastrointestinal Stability of 17 Peptide Drugs, Molecular Pharmaceutics, 12, 3, 2015. Crossref

  203. Grant Marshall, Leone-Bay Andrea, Peptide therapeutics: it’s all in the delivery, Therapeutic Delivery, 3, 8, 2012. Crossref

  204. Constance Jonathan E, Lim Carol S, Targeting malignant mitochondria with therapeutic peptides, Therapeutic Delivery, 3, 8, 2012. Crossref

  205. Chawla Ruchi, Rani Varsha, Mishra Mohini, Nanoparticulate Carriers—Versatile Delivery Systems, in Nanopharmaceutical Advanced Delivery Systems, 2021. Crossref

  206. Ovadia Oded, Greenberg Sarit, Chatterjee Jayanta, Laufer Burkhardt, Opperer Florian, Kessler Horst, Gilon Chaim, Hoffman Amnon, The Effect of Multiple N-Methylation on Intestinal Permeability of Cyclic Hexapeptides, Molecular Pharmaceutics, 8, 2, 2011. Crossref

  207. Hong Sungchae, Yum Soohwan, Yoo Hyun-Jung, Kang Sookjin, Yoon Jeong-Hyun, Min Dosik, Kim Young Mi, Jung Yunjin, Colon-Targeted Cell-Permeable NFκB Inhibitory Peptide Is Orally Active against Experimental Colitis, Molecular Pharmaceutics, 9, 5, 2012. Crossref

  208. Thompson Colin, Ibie Chidinma, The oral delivery of proteins using interpolymer polyelectrolyte complexes, Therapeutic Delivery, 2, 12, 2011. Crossref

  209. Zhang Chi, Duan Jiwen, Huang Yongxiang, Chen Ming, Enhanced Skin Delivery of Therapeutic Peptides Using Spicule-Based Topical Delivery Systems, Pharmaceutics, 13, 12, 2021. Crossref

  210. Alavi Seyed Ebrahim, Cabot Peter J., Moyle Peter M., Glucagon-Like Peptide-1 Receptor Agonists and Strategies To Improve Their Efficiency, Molecular Pharmaceutics, 16, 6, 2019. Crossref

  211. Wicke Niels, Bedford Mike R., Howarth Mark, Gastrobodies are engineered antibody mimetics resilient to pepsin and hydrochloric acid, Communications Biology, 4, 1, 2021. Crossref

  212. Lee Beom-Jin, Amin Hardik Hastibhai, Kang Taehee, Patient friendly strategy via chemical modification of proteins and peptides in oral delivery, in Advances and Challenges in Oral Delivery of Macromolecules, 2016. Crossref

  213. Jia Zhengyang, Wignall Anthony, Delon Ludivine, Guo Zhaobin, Prestidge Clive, Thierry Benjamin, An ex Vivo Model Enables Systematic Investigation of the Intestinal Absorption and Transcytosis of Oral Particulate Nanocarriers, ACS Biomaterials Science & Engineering, 2021. Crossref

  214. Rangasamy Loganathan, Chelvam Venkatesh, Kanduluru Ananda Kumar, Srinivasarao Madduri, Bandara N. Achini, You Fei, Orellana Esteban A., Kasinski Andrea L., Low Philip S., New Mechanism for Release of Endosomal Contents: Osmotic Lysis via Nigericin-Mediated K+/H+Exchange, Bioconjugate Chemistry, 29, 4, 2018. Crossref

  215. Serrano Lopez Dolores Remedios, Lalatsa Aikaterini, Peptide pills for brain diseases? Reality and future perspectives, Therapeutic Delivery, 4, 4, 2013. Crossref

  216. Brian Chia C. S., A Review on the Metabolism of 25 Peptide Drugs, International Journal of Peptide Research and Therapeutics, 27, 2, 2021. Crossref

  217. Chaudhri Owais B., Wynne Katie, Bloom Stephen R., Can Gut Hormones Control Appetite and Prevent Obesity?, Diabetes Care, 31, Supplement_2, 2008. Crossref

  218. Antunes Filipa, Andrade Fernanda, Sarmento Bruno, Chitosan‐Based Nanoparticulates for Oral Delivery of Biopharmaceuticals, in Chitosan‐Based Systems for Biopharmaceuticals, 2012. Crossref

  219. Shrestha Neha, Araújo Francisca, Shahbazi Mohammad-Ali, Mäkilä Ermei, Gomes Maria João, Airavaara Mikko, Kauppinen Esko I., Raula Janne, Salonen Jarno, Hirvonen Jouni, Sarmento Bruno, Santos Hélder A., Oral hypoglycaemic effect of GLP-1 and DPP4 inhibitor based nanocomposites in a diabetic animal model, Journal of Controlled Release, 232, 2016. Crossref

  220. Ahn Sukyung, Lee In-Hyun, Lee Eunhye, Kim Hyungjun, Kim Yong-Chul, Jon Sangyong, Oral delivery of an anti-diabetic peptide drug via conjugation and complexation with low molecular weight chitosan, Journal of Controlled Release, 170, 2, 2013. Crossref

  221. Zhang Yi, Meibohm Bernd, Pharmacokinetics and Pharmacodynamics of Therapeutic Peptides and Proteins, in Pharmaceutical Biotechnology, 2012. Crossref

  222. Sahu Kantrol Kumar, Minz Sunita, Kaurav Monika, Pandey Ravi Shankar, Proteins and peptides: The need to improve them as promising therapeutics for ulcerative colitis, Artificial Cells, Nanomedicine, and Biotechnology, 44, 2, 2016. Crossref

  223. Meibohm Bernd, Pharmacokinetics and Half‐Life of Protein Therapeutics, in Therapeutic Proteins, 2012. Crossref

  224. Lee Sehan, Cho Kwang-Hwi, Kang Young-Mook, Scheraga Harold A., No Kyoung Tai, A generalized G-SFED continuum solvation free energy calculation model, Proceedings of the National Academy of Sciences, 110, 8, 2013. Crossref

  225. Xie Tingting, Qiu Qingchuan, Zhang Wei, Ning Tingting, Yang Wei, Zheng Congyi, Wang Chuan, Zhu Yingguo, Yang Daichang, A biologically active rhIGF-1 fusion accumulated in transgenic rice seeds can reduce blood glucose in diabetic mice via oral delivery, Peptides, 29, 11, 2008. Crossref

  226. Foster Andrew D., Ingram James D., Leitch Eilidh K., Lennard Katherine R., Osher Eliot L., Tavassoli Ali, Methods for the Creation of Cyclic Peptide Libraries for Use in Lead Discovery, SLAS Discovery, 20, 5, 2015. Crossref

  227. Mahmood Iftekhar, Pettinato Mark, Impact of Intrinsic and Extrinsic Factors on the Pharmacokinetics of Peptides: When Is the Assessment of Certain Factors Warranted?, Antibodies, 11, 1, 2021. Crossref

  228. Ibrahim Yousif H-E.Y., Regdon Géza, Kristó Katalin, Kelemen András, Adam Mohamed E., Hamedelniel Elnazeer I., Sovány Tamás, Design and characterization of chitosan/citrate films as carrier for oral macromolecule delivery, European Journal of Pharmaceutical Sciences, 146, 2020. Crossref

  229. Isaacs Diana M., Kruger Davida F., Spollett Geralyn R., Optimizing Therapeutic Outcomes With Oral Semaglutide: A Patient-Centered Approach, Diabetes Spectrum, 34, 1, 2021. Crossref

  230. Dahan Arik, Tsume Yasuhiro, Sun Jing, Miller Jonathan M., Amidon Gordon L., Oral Bioavailability of Peptide and Peptidomimetic Drugs, in Amino Acids, Peptides and Proteins in Organic Chemistry, 2011. Crossref

  231. Prasad Kollur Shiva, Pillai Renjith Raveendran, Ghimire Madhav Prasad, Ray Rajyavardhan, Richter Manuel, Shivamallu Chandan, Jain Anisha S., Prasad Shashanka K., P Sushma, Armaković Stevan, Armaković Sanja J., Amachawadi Raghavendra G., Indole moiety induced biological potency in pseudo-peptides derived from 2-amino-2-(1H-indole-2-yl) based acetamides: Chemical synthesis, in vitro anticancer activity and theoretical studies, Journal of Molecular Structure, 1217, 2020. Crossref

  232. Asfour Marwa Hasanein, Advanced trends in protein and peptide drug delivery: a special emphasis on aquasomes and microneedles techniques, Drug Delivery and Translational Research, 11, 1, 2021. Crossref

  233. Takano Mikihisa, Koyama Yuka, Nishikawa Hiromi, Murakami Teruo, Yumoto Ryoko, Segment-selective absorption of lysozyme in the intestine, European Journal of Pharmacology, 502, 1-2, 2004. Crossref

  234. Aroda Vanita R., Rosenstock Julio, Terauchi Yasuo, Altuntas Yuksel, Lalic Nebojsa M., Morales Villegas Enrique C., Jeppesen Ole K., Christiansen Erik, Hertz Christin L., Haluzík Martin, Belkacem Krim, Chiali Nabil, Bourezane Samia, Guermaz Rachida, Popivanov Plamen, Lefterov Ivaylo, Tankova Tsvetalina, Penchev Ivan, Koskova Martina, Hudcova Miroslava, Vesela Alica, Rancova Anna, Haluzik Martin, Kiyosue Arihiro, Matsuoka Osamu, Inoue Satoshi, Terauchi Yasuo, Fukushima Yasushi, Ide Yumiko, Violante Ortiz Rafael Margarito, Morales Villegas Enrique, Golovach Albina, Alpenidze Diana, Frolova Elena, Zhdanova Elena, Ruyatkina Ludmila, Ershova Olga, Samoilova Yulia, Zyangirova Svetlana, Lalic Katarina, Lalic Nebojsa, Beljic Zivkovic Teodora, Ataoglu Esra, Bakiner Okan, Dayan Akin, Sargin Mehmet, Mert Meral, Adas Mine, Tabak Omur, Altuntas Yuksel, Murray Alexander, Iranmanesh Ali, Schlau Aron, Wieskopf Bram, Snyder Brian, Griffin Carl, Fogarty Charles, Lovell Charles, Allison Dale, Fitz-Patrick David, Grant David, Klonoff David, Williams Dwayne, Armas Eddie, Palace Eileen, Ruoff Gary, Martinez Gilbert, Perez Gilberto, Bays Harold, Tatu Horia, Maynard James, Cedeno Jeanne-Elyse, Aroda Vanita, Park Jean, Sutton Jennefer, Pouzar Joe, Bertsch John, Condit Jonathan, Serje Jorge, Cabaccan Josel, Risser Joseph, Frias Juan, Rosenstock Julio, Sivalingam Kanagaratnam, Maw Kelli, Hanson Lenita, Billings Liana, Connery Lisa, Juarez Mario, Lillestol Michael, Fraser Neil, Beckett Paul, Wade Ralph, Gaona Raul, Jackson Richard, DeLuca Robert, Alpizar Sady, Herring Sharon, Stringam Stanley, Bauer Steven, Gangi Sumana, Sligh Teresa, Jarrett Wentworth, Fitzgibbons William, PIONEER 1: Randomized Clinical Trial of the Efficacy and Safety of Oral Semaglutide Monotherapy in Comparison With Placebo in Patients With Type 2 Diabetes, Diabetes Care, 42, 9, 2019. Crossref

  235. Shamkhalova M. Sh., Shestakova M. V., Efficacy and safety of oral semaglutide in Russian patients with type 2 diabetes: subgroup analysis of PIONEER 1, 2, 3 trials, Diabetes mellitus, 25, 3, 2022. Crossref

  236. Yuan Qian, Su Kui, Li Shuyi, Long Xinyi, Liu Lang, Yang Minghui, Yuan Xin, Sun Jianwu, Hu Junhua, Li Qin, Zhao Yu, Yuan Zhengqiang, Pulmonary Delivery of Extracellular Vesicle-Encapsulated Dinaciclib as an Effective Lung Cancer Therapy, Cancers, 14, 14, 2022. Crossref

  237. Sábio Rafael Miguel, Meneguin Andréia Bagliotti, Martins dos Santos Aline, Monteiro Andreia Sofia, Chorilli Marlus, Exploiting mesoporous silica nanoparticles as versatile drug carriers for several routes of administration, Microporous and Mesoporous Materials, 312, 2021. Crossref

  238. Yamada Yuichiro, Katagiri Hideki, Hamamoto Yoshiyuki, Deenadayalan Srikanth, Navarria Andrea, Nishijima Keiji, Seino Yutaka, Fukushima Y, Hamamoto Y, Hisatomi A, Ide Y, Inoue S, Kawada T, Kim H, Kiyosue A, Matoba K, Matsuoka O, Nishimura H, Noguchi M, Osonoi T, Sawada S, Shibasaki Y, Shin K, Yamada Y, Dose-response, efficacy, and safety of oral semaglutide monotherapy in Japanese patients with type 2 diabetes (PIONEER 9): a 52-week, phase 2/3a, randomised, controlled trial, The Lancet Diabetes & Endocrinology, 8, 5, 2020. Crossref

  239. van Schaik Pauline E. M., Zuhorn Inge S., Baron Wia, Targeting Fibronectin to Overcome Remyelination Failure in Multiple Sclerosis: The Need for Brain- and Lesion-Targeted Drug Delivery, International Journal of Molecular Sciences, 23, 15, 2022. Crossref

  240. Guo Yiyue, Yang Yuqi, Xu You, Meng Yingying, Ye Jun, Xia Xuejun, Liu Yuling, Deformable Nanovesicle-Loaded Gel for Buccal Insulin Delivery, Pharmaceutics, 14, 11, 2022. Crossref

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