图书馆订阅: Guest
医药载体系统评论综述

每年出版 6 

ISSN 打印: 0743-4863

ISSN 在线: 2162-660X

The Impact Factor measures the average number of citations received in a particular year by papers published in the journal during the two preceding years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) IF: 2.7 To calculate the five year Impact Factor, citations are counted in 2017 to the previous five years and divided by the source items published in the previous five years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) 5-Year IF: 3.6 The Immediacy Index is the average number of times an article is cited in the year it is published. The journal Immediacy Index indicates how quickly articles in a journal are cited. Immediacy Index: 0.8 The Eigenfactor score, developed by Jevin West and Carl Bergstrom at the University of Washington, is a rating of the total importance of a scientific journal. Journals are rated according to the number of incoming citations, with citations from highly ranked journals weighted to make a larger contribution to the eigenfactor than those from poorly ranked journals. Eigenfactor: 0.00023 The Journal Citation Indicator (JCI) is a single measurement of the field-normalized citation impact of journals in the Web of Science Core Collection across disciplines. The key words here are that the metric is normalized and cross-disciplinary. JCI: 0.39 SJR: 0.42 SNIP: 0.89 CiteScore™:: 5.5 H-Index: 79

Indexed in

Engineered PLGA Nanoparticles: An Emerging Delivery Tool in Cancer Therapeutics

卷 28, 册 1, 2011, pp. 1-45
DOI: 10.1615/CritRevTherDrugCarrierSyst.v28.i1.10
Get accessGet access

摘要

Nanocarriers formulated with the US Food and Drug Administration-approved biocompatible and biodegradable polymer poly(lactic-co-glycolic acid) (PLGA) are being widely explored for the controlled delivery of therapeutic drugs, proteins, peptides, oligonucleotides, and genes. Surface functionalization of PLGA nanoparticles has paved the way to a variety of engineered PLGA-based nanocarriers, which, depending on reticular requirements, can demonstrate a wide variety of combined properties and functions such as prolonged residence time in blood circulation, enhanced oral bioavailability, site-specific drug delivery, and tailored release characteristics. The present review highlights the recent leaps in PLGA-based nanotechnology with a particular focus on cancer therapeutics. Starting with a brief introduction to cancer nanotechnology, we then discuss developmental aspects and the in vitro and in vivo efficacy of PLGA-based nanocarriers in terms of targeted drug or gene delivery. The main objective of this review is to convey information about the state of art and to critically address the limitations and the need for further progress and clinical developments in this emerging technology.

对本文的引用
  1. Fields Rachel J., Cheng Christopher J., Quijano Elias, Weller Caroline, Kristofik Nina, Duong Nha, Hoimes Christopher, Egan Marie E., Saltzman W. Mark, Surface modified poly(β amino ester)-containing nanoparticles for plasmid DNA delivery, Journal of Controlled Release, 164, 1, 2012. Crossref

  2. Srinivas Mangala, Boehm-Sturm Philipp, Figdor Carl G., de Vries I. Jolanda, Hoehn Mathias, Labeling cells for in vivo tracking using 19F MRI, Biomaterials, 33, 34, 2012. Crossref

  3. Patravale Vandana, Dandekar Prajakta, Jain Ratnesh, Nanoparticulate systems as drug carriers: the need, in Nanoparticulate Drug Delivery, 2012. Crossref

  4. Ungaro Francesca, d' Angelo Ivana, Miro Agnese, La Rotonda Maria I, Quaglia Fabiana, Engineered PLGA nano- and micro-carriers for pulmonary delivery: challenges and promises, Journal of Pharmacy and Pharmacology, 64, 9, 2012. Crossref

  5. Bell Iris R., Schwartz Gary E., Boyer Nancy N., Koithan Mary, Brooks Audrey J., Advances in integrative nanomedicine for improving infectious disease treatment in public health, European Journal of Integrative Medicine, 5, 2, 2013. Crossref

  6. Rosalia Rodney A., Silva Ana Luisa, Camps Marcel, Allam Ahmed, Jiskoot Wim, van der Burg Sjoerd H., Ossendorp Ferry, Oostendorp Jaap, Efficient ex vivo induction of T cells with potent anti-tumor activity by protein antigen encapsulated in nanoparticles, Cancer Immunology, Immunotherapy, 62, 7, 2013. Crossref

  7. Thanki Kaushik, Gangwal Rahul P., Sangamwar Abhay T., Jain Sanyog, Oral delivery of anticancer drugs: Challenges and opportunities, Journal of Controlled Release, 170, 1, 2013. Crossref

  8. Xu Hao, Kona Soujanya, Su Lee-Chun, Tsai Yi-Ting, Dong Jing-Fei, Brilakis Emmanouil S., Tang Liping, Banerjee Subhash, Nguyen Kytai T., Multi-Ligand Poly(l-Lactic-co-Glycolic Acid) Nanoparticles Inhibit Activation of Endothelial Cells, Journal of Cardiovascular Translational Research, 6, 4, 2013. Crossref

  9. Kiparissides Costas, Kammona Olga, Nanoscale carriers for targeted delivery of drugs and therapeutic biomolecules, The Canadian Journal of Chemical Engineering, 91, 4, 2013. Crossref

  10. Félix Lanao Rosa P., Bosco Ruggero, Leeuwenburgh Sander C. G., Kersten-Niessen Monique J. F., Wolke Joop G. C., van den Beucken Jeroen J. J. P., Jansen John A., RANKL delivery from calcium phosphate containing PLGA microspheres, Journal of Biomedical Materials Research Part A, 2013. Crossref

  11. Korin Netanel, Kanapathipillai Mathumai, Ingber Donald E., Shear-Responsive Platelet Mimetics for Targeted Drug Delivery, Israel Journal of Chemistry, 2013. Crossref

  12. Bladder Tissue Engineering, in Introduction to Tissue Engineering, 2014. Crossref

  13. Kona Soujanya, Dong Jing-Fei, Liu Yaling, Tan Jifu, Nguyen Kytai T., Biodegradable nanoparticles mimicking platelet binding as a targeted and controlled drug delivery system, International Journal of Pharmaceutics, 423, 2, 2012. Crossref

  14. Luo Cong, Sun Jin, Du Yuqian, He Zhonggui, Emerging integrated nanohybrid drug delivery systems to facilitate the intravenous-to-oral switch in cancer chemotherapy, Journal of Controlled Release, 176, 2014. Crossref

  15. Zheng Linfeng, Li Kangan, Han Yuedong, Wei Wei, Zheng Sujuan, Zhang Guixiang, In vivo targeted peripheral nerve imaging with a nerve-specific nanoscale magnetic resonance probe, Medical Hypotheses, 83, 5, 2014. Crossref

  16. Uskoković Vuk, Desai Tejal A, Nanoparticulate drug delivery platforms for advancing bone infection therapies, Expert Opinion on Drug Delivery, 11, 12, 2014. Crossref

  17. Sharma Shweta, Parmar Ankush, Kori Shivpoojan, Sandhir Rajat, PLGA-based nanoparticles: A new paradigm in biomedical applications, TrAC Trends in Analytical Chemistry, 80, 2016. Crossref

  18. Büll Christian, Boltje Thomas Jan, van Dinther Eric A. W., Peters Timo, de Graaf Annemarie M. A., Leusen Jeanette H. W., Kreutz Martin, Figdor Carl G., den Brok Martijn H., Adema Gosse J., Targeted Delivery of a Sialic Acid-Blocking Glycomimetic to Cancer Cells Inhibits Metastatic Spread, ACS Nano, 9, 1, 2015. Crossref

  19. Schiller Stefan, Hanefeld Andrea, Schneider Marc, Lehr Claus-Michael, Focused Ultrasound as a Scalable and Contact-Free Method to Manufacture Protein-Loaded PLGA Nanoparticles, Pharmaceutical Research, 32, 9, 2015. Crossref

  20. Swarnakar Nitin K., Jain Amit K., Singh Raman P., Godugu Chandraiah, Das Manasmita, Jain Sanyog, Oral bioavailability, therapeutic efficacy and reactive oxygen species scavenging properties of coenzyme Q10-loaded polymeric nanoparticles, Biomaterials, 32, 28, 2011. Crossref

  21. Ajorlou Elham, Khosroushahi Ahmad Yari, Trends on polymer- and lipid-based nanostructures for parenteral drug delivery to tumors, Cancer Chemotherapy and Pharmacology, 79, 2, 2017. Crossref

  22. Jain Amit K., Jain Sanyog, Advances in oral delivery of anti-cancer prodrugs, Expert Opinion on Drug Delivery, 13, 12, 2016. Crossref

  23. Doppalapudi Sindhu, Jain Anjali, Domb Abraham J., Khan Wahid, Biodegradable polymers for targeted delivery of anti-cancer drugs, Expert Opinion on Drug Delivery, 13, 6, 2016. Crossref

  24. Sun Dongdong, Li Nuan, Zhang Weiwei, Zhao Zhiwei, Mou Zhipeng, Huang Donghui, Liu Jie, Wang Weiyun, Design of PLGA-functionalized quercetin nanoparticles for potential use in Alzheimer’s disease, Colloids and Surfaces B: Biointerfaces, 148, 2016. Crossref

  25. Durán-Lobato Matilde, Holgado Maria, Álvarez-Fuentes Josefa, Arias José, Fernández-Arévalo Mercedes, Martín-Banderas Lucía, Peroral Polyester Drug Delivery Systems, in Handbook of Polyester Drug Delivery Systems, 2016. Crossref

  26. Mehra Neelesh K., Jain Amit K., Nahar Manoj, Carbon nanomaterials in oncology: an expanding horizon, Drug Discovery Today, 23, 5, 2018. Crossref

  27. Jahan Sheikh Tasnim, Sadat Sams M. A., Walliser Matthew, Haddadi Azita, Targeted Therapeutic Nanoparticles: An Immense Promise to Fight against Cancer, Journal of Drug Delivery, 2017, 2017. Crossref

  28. CHANG PEI-YING, PENG SHU-FEN, LEE CHAO-YING, LU CHI-CHENG, TSAI SHIH-CHANG, SHIEH TZONG-MING, WU TIAN-SHUNG, TU MING-GENE, CHEN MICHAEL YUANCHIEN, YANG JAI-SING, Curcumin-loaded nanoparticles induce apoptotic cell death through regulation of the function of MDR1 and reactive oxygen species in cisplatin-resistant CAR human oral cancer cells, International Journal of Oncology, 43, 4, 2013. Crossref

  29. Kim Yeon Sun, Park Ji Sun, Park Mira, Ko Min Yeon, Yi Se Won, Yoon Jung Ah, Yang SeungChel, Shim Sung Han, Park Keun-Hong, Song Haengseok, PLGA nanoparticles with multiple modes are a biologically safe nanocarrier for mammalian development and their offspring, Biomaterials, 183, 2018. Crossref

  30. Roointan Amir, Kianpour Sedigheh, Memari Fatemeh, Gandomani Molood, Gheibi Hayat Seyed Mohammad, Mohammadi-Samani Soliman, Poly(lactic-co-glycolic acid): The most ardent and flexible candidate in biomedicine!, International Journal of Polymeric Materials and Polymeric Biomaterials, 67, 17, 2018. Crossref

  31. Datir Sagar Satish, Plant Metabolites as New Leads to Anticancer Drug Discovery: Approaches and Challenges, in Anticancer Plants: Natural Products and Biotechnological Implements, 2018. Crossref

  32. Dong Hao, Wu Guoyu, Xu Hong, Zhang Chenghong, Wang Jiao, Gao Meng, Pang Yue, Zhang Houli, Zhang Baojing, Tian Yan, Li Qingwei, N-acetylaminogalactosyl-decorated biodegradable PLGA-TPGS copolymer nanoparticles containing emodin for the active targeting therapy of liver cancer, Artificial Cells, Nanomedicine, and Biotechnology, 46, sup2, 2018. Crossref

  33. Zheng Jin, Qi Jianguo, Zou Quan, Zhang Zhenzhong, Construction of PLGA/JNK3-shRNA nanoparticles and their protective role in hippocampal neuron apoptosis induced by oxygen and glucose deprivation, RSC Advances, 8, 36, 2018. Crossref

  34. Han Yu, Zhao Ruibo, Xu Feng, Neutrophil-Based Delivery Systems for Nanotherapeutics, Small, 14, 42, 2018. Crossref

  35. Agrawal Mukta, Saraf Swarnlata, Saraf Shailendra, Antimisiaris Sophia G., Hamano Nobuhito, Li Shyh-Dar, Chougule Mahavir, Shoyele Sunday A., Gupta Umesh, Ajazuddin , Alexander Amit, Recent advancements in the field of nanotechnology for the delivery of anti-Alzheimer drug in the brain region, Expert Opinion on Drug Delivery, 15, 6, 2018. Crossref

  36. Swarnakar Nitin Kumar, Venkatesan Natarajan, Betageri Guru, Critical In Vitro Characterization Methods of Lipid-Based Formulations for Oral Delivery: a Comprehensive Review, AAPS PharmSciTech, 20, 1, 2019. Crossref

  37. Kumar Pramod, Gajbhiye Kavita R., Paknikar Kishore M., Gajbhiye Virendra, Current Status and Future Challenges of Various Polymers as Cancer Therapeutics, in Polymeric Nanoparticles as a Promising Tool for Anti-cancer Therapeutics, 2019. Crossref

  38. Jain Anjali, Khan Wahid, Kyzioł Agnieszka, Particulate systems of PLA and its copolymers, in Materials for Biomedical Engineering, 2019. Crossref

  39. Agrawal Ashish Kumar, Urimi Dileep, Jain Sanyog, Multifunctional Polymeric Nano-Carriers in Targeted Drug Delivery, in Targeted Drug Delivery : Concepts and Design, 2015. Crossref

  40. Alvarado Yolanda, Muro Claudia, Illescas Javier, Riera Francisco, Polymer nanoparticles for the release of complex molecules, in Materials for Biomedical Engineering, 2019. Crossref

  41. Khan Haroon, Mirzaei Hamid Reza, Amiri Atefeh, Kupeli Akkol Esra, Ashhad Halimi Syed Muhammad, Mirzaei Hamed, Glyco-nanoparticles: New drug delivery systems in cancer therapy, Seminars in Cancer Biology, 69, 2021. Crossref

  42. Elmowafy Enas M., Tiboni Mattia, Soliman Mahmoud E., Biocompatibility, biodegradation and biomedical applications of poly(lactic acid)/poly(lactic-co-glycolic acid) micro and nanoparticles, Journal of Pharmaceutical Investigation, 49, 4, 2019. Crossref

  43. Tran Phuong, Lee Sang-Eun, Kim Dong-Hyun, Pyo Yong-Chul, Park Jeong-Sook, Recent advances of nanotechnology for the delivery of anticancer drugs for breast cancer treatment, Journal of Pharmaceutical Investigation, 50, 3, 2020. Crossref

  44. Swider Edyta, Srinivas Mangala, Spinning to a Different Beat: 19F Agents for “Hot-Spot” Cellular MR Imaging, in Design and Applications of Nanoparticles in Biomedical Imaging, 2017. Crossref

  45. Hwang Lee S., Krivosheya Daria, Vogelbaum Michael A., Clinical Methods of Nervous System Drug Delivery for Tumors, in Nervous System Drug Delivery, 2019. Crossref

  46. Mohanrasu K., Siva Prakash G., Boobalan T., Ananthi V., Dinesh G. H., Anand K., Sudhakar M., Chuturgoon Anil, Arun A., Synthetic, Natural Derived Lipid Nanoparticles and Polymeric Nanoparticles Drug Delivery Applications, in Integrative Nanomedicine for New Therapies, 2020. Crossref

  47. Shibata Seiji B., West Matthew B., Du Xiaoping, Iwasa Yoichiro, Raphael Yehoash, Kopke Richard D., Gene therapy for hair cell regeneration: Review and new data, Hearing Research, 394, 2020. Crossref

  48. Kumari Priyanka, Luqman Suaib, Meena Abha, Nanomaterials: A Promising Tool for Drug Delivery, in Nanoscience in Medicine Vol. 1, 39, 2020. Crossref

  49. Mankamna Kumari R., Goswami Ritu, Nimesh Surendra, Application of Nanotechnology in Diagnosis and Therapeutics, in Nanotechnology for Energy and Environmental Engineering, 2020. Crossref

  50. Shah Sunny R, Prajapati Hani R, Sheth Devang B, Gondaliya Ekta M, Vyas Amit J, Soniwala Moinuddin M, Chavda Jayant R, Pharmacokinetics and in vivo distribution of optimized PLGA nanoparticles for pulmonary delivery of levofloxacin, Journal of Pharmacy and Pharmacology, 72, 8, 2020. Crossref

  51. Parveen Shaheda, Fatima Saman, Quadri Syed Naved, Beg Sarwar, Abdin M.Z., Surface-decoration strategies in nanomedicine for cancer treatment, in Nanoformulation Strategies for Cancer Treatment, 2021. Crossref

  52. Sohrabi Somayeh, Khedri Mohammad, Maleki Reza, Keshavarz Moraveji Mostafa, Molecular engineering of the last-generation CNTs in smart cancer therapy by grafting PEG–PLGA–riboflavin, RSC Advances, 10, 67, 2020. Crossref

  53. Lai Yen-Ho, Chiang Chih-Sheng, Hsu Chin-Hao, Cheng Hung-Wei, Chen San-Yuan, Development and Characterization of a Fucoidan-Based Drug Delivery System by Using Hydrophilic Anticancer Polysaccharides to Simultaneously Deliver Hydrophobic Anticancer Drugs, Biomolecules, 10, 7, 2020. Crossref

  54. Varani Michela, Galli Filippo, Capriotti Gabriela, Mattei Maurizio, Cicconi Rosella, Campagna Giuseppe, Panzuto Francesco, Signore Alberto, Theranostic Designed Near-Infrared Fluorescent Poly (Lactic-co-Glycolic Acid) Nanoparticles and Preliminary Studies with Functionalized VEGF-Nanoparticles, Journal of Clinical Medicine, 9, 6, 2020. Crossref

  55. Maleki Reza, Khedri Mohammad, Malekahmadi Donya, Mohaghegh Seraj, Jahromi Ahmad Miri, Shahbazi Mohammad-Ali, Simultaneous doxorubicin encapsulation and in-situ microfluidic micellization of bio-targeted polymeric nanohybrids using dichalcogenide monolayers: A molecular in-silico study, Materials Today Communications, 26, 2021. Crossref

  56. Kanapathipillai Mathumai, Mammoto Akiko, Mammoto Tadanori, Kang Joo H., Jiang Elisabeth, Ghosh Kaustabh, Korin Netanel, Gibbs Ashley, Mannix Robert, Ingber Donald E., Inhibition of Mammary Tumor Growth Using Lysyl Oxidase-Targeting Nanoparticles to Modify Extracellular Matrix, Nano Letters, 12, 6, 2012. Crossref

  57. Jain Sanyog, Rathi Vishal V, Jain Amit K, Das Manasmita, Godugu Chandraiah, Folate-decorated PLGA nanoparticles as a rationally designed vehicle for the oral delivery of insulin, Nanomedicine, 7, 9, 2012. Crossref

  58. Zhao Yunqi, Duan Shaofeng, Zeng Xing, Liu Chunjing, Davies Neal M., Li Benyi, Forrest M. Laird, Prodrug Strategy for PSMA-Targeted Delivery of TGX-221 to Prostate Cancer Cells, Molecular Pharmaceutics, 9, 6, 2012. Crossref

  59. Jain Sanyog, Patil Swapnil R., Swarnakar Nitin K., Agrawal Ashish K., Oral Delivery of Doxorubicin Using Novel Polyelectrolyte-Stabilized Liposomes (Layersomes), Molecular Pharmaceutics, 9, 9, 2012. Crossref

  60. Piotrowski-Daspit Alexandra S., Kauffman Amy C., Bracaglia Laura G., Saltzman W. Mark, Polymeric vehicles for nucleic acid delivery, Advanced Drug Delivery Reviews, 156, 2020. Crossref

  61. Yanes Rolando E, Tamanoi Fuyuhiko, Development of mesoporous silica nanomaterials as a vehicle for anticancer drug delivery, Therapeutic Delivery, 3, 3, 2012. Crossref

  62. Jain Amit K., Thanki Kaushik, Jain Sanyog, Co-encapsulation of Tamoxifen and Quercetin in Polymeric Nanoparticles: Implications on Oral Bioavailability, Antitumor Efficacy, and Drug-Induced Toxicity, Molecular Pharmaceutics, 10, 9, 2013. Crossref

  63. Korin Netanel, Mechanoresponsive nanotherapeutic for localized drug delivery to flow obstructed blood vessels, Therapeutic Delivery, 6, 8, 2015. Crossref

  64. Kammona Olga, Bourganis Vassilis, Karamanidou Theodora, Kiparissides Costas, Recent developments in nanocarrier-aided mucosal vaccination, Nanomedicine, 12, 9, 2017. Crossref

  65. Shaik Baji Baba, Katari Naresh Kumar, Krishnan Anand, Nanostructured Materials for Cancer Diagnosis and Therapeutics, in Engineered Nanomaterials for Innovative Therapies and Biomedicine, 2022. Crossref

  66. Rath Goutam, Pradhan Deepak, Ghosh Goutam, Goyal Amit K., Challenges and Opportunities of Nanotechnological based Approach for the Treatment of Tuberculosis, Current Pharmaceutical Design, 27, 17, 2021. Crossref

  67. Hamidia Zahra, Shahanipour Kahin, Talebian Nasrin, Monajemi Ramesh, Preparation of chelidonine highly loaded poly(lactide-co-glycolide)-based nanoparticles using a single emulsion method: Cytotoxic effect on MDA-MB-231 cell line, Journal of Herbmed Pharmacology, 11, 1, 2021. Crossref

  68. Bandiwadekar Akshay, Jose Jobin, Khayatkashani Maryam, Habtemariam Solomon, Khayat Kashani Hamid Reza, Nabavi Seyed Mohammad, Emerging Novel Approaches for the Enhanced Delivery of Natural Products for the Management of Neurodegenerative Diseases, Journal of Molecular Neuroscience, 72, 3, 2022. Crossref

  69. Musumeci Teresa, Bucolo Claudio, Carbone Claudia, Pignatello Rosario, Drago Filippo, Puglisi Giovanni, Polymeric nanoparticles augment the ocular hypotensive effect of melatonin in rabbits, International Journal of Pharmaceutics, 440, 2, 2013. Crossref

  70. Swider Edyta, Koshkina Olga, Tel Jurjen, Cruz Luis J., de Vries I. Jolanda M., Srinivas Mangala, Customizing poly(lactic-co-glycolic acid) particles for biomedical applications, Acta Biomaterialia, 73, 2018. Crossref

  71. Bhatt Kajol, Patil Pravin, Jani Parva, Thakkar Parth, Sawant Krutika, Design and evaluation of hyaluronic acid-coated PLGA nanoparticles of raloxifene hydrochloride for treatment of breast cancer, Drug Development and Industrial Pharmacy, 47, 12, 2021. Crossref

  72. Fakhoury Marc, Drug delivery approaches for the treatment of glioblastoma multiforme, Artificial Cells, Nanomedicine, and Biotechnology, 44, 6, 2016. Crossref

  73. Shah Sunny, Cristopher Dhanya, Sharma Shweta, Soniwala Moinuddin, Chavda Jayant, Inhalable linezolid loaded PLGA nanoparticles for treatment of tuberculosis: Design, development and in vitro evaluation, Journal of Drug Delivery Science and Technology, 60, 2020. Crossref

  74. Wang Shuhang, Cheng Keman, Chen Kun, Xu Chen, Ma Peiwen, Dang Guohui, Yang Yuqi, Lei Qi, Huang Huiyao, Yu Yue, Fang Yuan, Tang Qiyu, Jiang Ning, Miao Huilei, Liu Funan, Zhao Xiao, Li Ning, Nanoparticle-based medicines in clinical cancer therapy, Nano Today, 45, 2022. Crossref

  75. Chen Xuan, Chen Shangli, Chen Junyong, Jia Haiying, Tang Zhi, Hyaluronic Acid-Modified Poly-Beta-Amino-Esters for Adriamycin Delivery Against Nasopharyngeal Carcinoma, Journal of Biomedical Nanotechnology, 18, 5, 2022. Crossref

  76. Shahriar S. M. Shatil, Andrabi Syed Muntazir, Islam Farhana, An Jeong Man, Schindler Samantha J., Matis Mitchell P., Lee Dong Yun, Lee Yong-kyu, Next-Generation 3D Scaffolds for Nano-Based Chemotherapeutics Delivery and Cancer Treatment, Pharmaceutics, 14, 12, 2022. Crossref

Begell Digital Portal Begell 数字图书馆 电子图书 期刊 参考文献及会议录 研究收集 订购及政策 Begell House 联系我们 Language English 中文 Русский Português German French Spain