图书馆订阅: Guest
Begell Digital Portal Begell 数字图书馆 电子图书 期刊 参考文献及会议录 研究收集
医药载体系统评论综述
影响因子: 2.9 5年影响因子: 3.72 SJR: 0.573 SNIP: 0.551 CiteScore™: 2.43

ISSN 打印: 0743-4863
ISSN 在线: 2162-660X

医药载体系统评论综述

DOI: 10.1615/CritRevTherDrugCarrierSyst.v28.i1.20
pages 47-99

Gastroretentive Floating Drug-Delivery Systems: A Critical Review

Udaya Kotreka
Boehringer Ingelheim Roxane Lboratories, Inc
Moji Christianah Adeyeye
Department of Biopharmaceutical Sciences College of Pharmacy, Roosevelt University, Schaumburg, IL, USA

ABSTRACT

The oral delivery of drugs with a narrow absorption window in the gastrointestinal tract (GIT) is often limited by poor bioavailability with conventional dosage forms due to incomplete drug release and short residence time at the site of absorption. To overcome this drawback and to maximize the oral absorption of these drugs, gastroretentive systems such as mucoadhesive, high-density, expandable, and floating systems have been developed. These systems provide controlled delivery of drugs with prolonged gastric residence time. However, in humans, differences in various physiological and biological factors can affect the gastric residence time and drug-delivery behavior from gastroretentive systems. Some floating drugdelivery systems (FDDS) have shown the capability to accommodate these variations without affecting drug release. This review mainly focuses on various physiological considerations for development of FDDS, and highlights recent technological developments including new dosage forms and their production techniques (e.g., holt-melt extrusion, melt pelletization, and pulsed plasma-irradiation processes). Alternatives to the existing in vitro compendial methods for evaluating floating dosage forms will be discussed, and a critical analysis of the existing literature on FDDS, identifying the potential areas for future research, is provided.


Articles with similar content:

Pharmacoscintigraphy: A Blazing Trail for the Evaluation of New Drugs and Delivery Systems
Critical Reviews™ in Therapeutic Drug Carrier Systems, Vol.26, 2009, issue 4
Prateek Dani, Sanyog Jain, Rakesh Kumar Sharma
Nanosuspensions in Drug Delivery: Recent Advances, Patent Scenarios, and Commercialization Aspects
Critical Reviews™ in Therapeutic Drug Carrier Systems, Vol.28, 2011, issue 5
Krutika Sawant, Kailash C. Petkar, Sandip S. Chavhan
Stimuli-Responsive Systems with Diverse Drug Delivery and Biomedical Applications: Recent Updates and Mechanistic Pathways
Critical Reviews™ in Therapeutic Drug Carrier Systems, Vol.34, 2017, issue 3
Ranjot Kaur, Sumant Saini, Bhupinder Singh, Rajneet Kaur Khurana, Babita Garg
Overview on Therapeutic Applications of Microparticulate Drug Delivery Systems
Critical Reviews™ in Therapeutic Drug Carrier Systems, Vol.33, 2016, issue 4
Swarna Bale, Mandip Singh, A. Shiva Shankar Reddy, Amit Khurana, Chandraiah Godugu
Mucosal Drug Delivery: Membranes, Methodologies, and Applications
Critical Reviews™ in Therapeutic Drug Carrier Systems, Vol.21, 2004, issue 3
Bozena Michniak, Yifan Song, Rashmi Thakur, Victor M. Meidan, Yiping Wang