图书馆订阅: Guest
Begell Digital Portal Begell 数字图书馆 电子图书 期刊 参考文献及会议录 研究收集
医药载体系统评论综述
影响因子: 2.9 5年影响因子: 3.72 SJR: 0.736 SNIP: 0.551 CiteScore™: 2.43

ISSN 打印: 0743-4863
ISSN 在线: 2162-660X

医药载体系统评论综述

DOI: 10.1615/CritRevTherDrugCarrierSyst.v18.i6.30
24 pages

Capture of Stealth Nanoparticles by the Body’s Defences

S. Moein Moghimi
Molecular Targeting and Polymer Toxicology Group, School of Pharmacy and Biomolecular Sciences, Cockcroft Building, University of Brighton, Brighton BN2 4GJ, UK
Christy Hunter
Molecular Targeting and Polymer Toxicology Group, School of Pharmacy and Biomolecular Sciences, Cockcroft Building, University of Brighton, Brighton BN2 4GJ, UK

ABSTRACT

This article highlights and discusses our experience in the design, handling, and biological evaluation of long-circulating nanoparticles based on polyoxypropylene/polyoxyethylene copolymer nonionic surfactants. A frequently observed but ignored phenomenon following intravenous injection of such polymer-modified long-circulating colloidal systems is their eventual recognition and clearance by macrophages of the reticuloendothelial system. The pharmacokinetics as well as the tissue distribution of such so-called “stealth” nanoparticles are also altered after repeated intravenous injection in a time-dependent manner. An understanding of immunological and pathological factors that control the pharmacokinetic and biological behavior of long-circulating particles after single or repeated administration is therefore crucial for the design of a system with an optimal diagnostic and/or therapeutic performance. Therefore, we have also examined and discussed the concept of macrophage recognition of a “stealth-like nature” and factors that initiate this cascade. A critical discussion of the future of this interesting area of nano-biotechnology/engineering is also provided.


Articles with similar content:

Fungal Capsular Polysaccharide and T-Cell Suppression: The Hidden Nature of Poor Immunogenicity
Critical Reviews™ in Immunology, Vol.27, 2007, issue 6
Anna Vecchiarelli
Pleiotropic Roles of TGFβ/Smad Signaling in the Progression of Chronic Liver Disease
Critical Reviews™ in Eukaryotic Gene Expression, Vol.23, 2013, issue 3
DeAn Tian, LiHong XU, Yong Zheng
Structural Plasticity of the Proteasome and Its Function in Antigen Processing
Critical Reviews™ in Immunology, Vol.21, 2001, issue 4
Maries van den Broek, Annalisa Macagno, Marcus Groettrup, Katrin Schwarz, Rita de Giuli, Gunter Schmidtke, Selina Khan
Mechanism and Consequences of δ-Opioid Receptor Internalization
Critical Reviews™ in Neurobiology, Vol.17, 2005, issue 1
Rudiger Schulz, Daniela A. Eisinger
Current Data on ATP-Containing Liposomes and Potential Prospects To Enhance Cellular Energy Status for Hepatic Applications
Critical Reviews™ in Therapeutic Drug Carrier Systems, Vol.25, 2008, issue 4
V. Korb, D. Scherman, G. Dumortier, L. Cynober, C. Richard, K. Tep, J. C. Chaumeil, V. Escriou