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医药载体系统评论综述
影响因子: 2.9 5年影响因子: 3.72 SJR: 0.736 SNIP: 0.551 CiteScore™: 2.43

ISSN 打印: 0743-4863
ISSN 在线: 2162-660X

医药载体系统评论综述

DOI: 10.1615/CritRevTherDrugCarrierSyst.v15.i5.30
43 pages

Hyaluronate Derivatives in Drug Delivery

Koen P. Vercruysse
Department of Medicinal Chemistry, 30 South 2000 East, Room 201, College of Pharmacy, University of Utah, Salt Lake City, Utah 84112-5820, U.S.A.
Glenn D. Prestwich
Department of Medicinal Chemistry, 30 South 2000 East, Room 201, College of Pharmacy, University of Utah, Salt Lake City, Utah 84112-5820, U.S.A.

ABSTRACT

Hyaluronan (HA), an abundant nonsulfated glycosaminoglycan component of synovial fluid and the extracellular matrix, is an attractive building block for new biocompatible and biodegradable polymers that have applications in drug delivery, tissue engineering, and viscosupplementation. This review consists of three subtopics: (i) chemical modification of HA; (ii) physicochemical and biochemical characterization of HA derivatives; and (iii) in vitro and in vivo bioevaluation studies. Important new products have already reached the marketplace, and the approval and introduction of a variety of new medical applications of HA-based biomaterials can be anticipated in the next decade.


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