图书馆订阅: Guest
Begell Digital Portal Begell 数字图书馆 电子图书 期刊 参考文献及会议录 研究收集
医药载体系统评论综述
影响因子: 2.9 5年影响因子: 3.72 SJR: 0.736 SNIP: 0.551 CiteScore™: 2.43

ISSN 打印: 0743-4863
ISSN 在线: 2162-660X

医药载体系统评论综述

DOI: 10.1615/CritRevTherDrugCarrierSyst.v21.i5.20
36 pages

PLGA Nanoparticles in Drug Delivery: The State of the Art

Indu Bala
Department of Pharmaceutics, National Institute of Pharmaceutical Education and Research (NIPER), Punjab, India
Sarita Hariharan
Department of Pharmaceutics, National Institute of Pharmaceutical Education and Research (NIPER), Punjab, India
M. N. V. Ravi Kumar
Department of Pharmaceutics, National Institute of Pharmaceutical Education and Research (NIPER), Punjab, India

ABSTRACT

Nanoparticles represent drug delivery systems suitable for most administration routes. Over the years, a variety of natural and synthetic polymers have been explored for the preparation of nanoparticles, of which Poly(lactic acid) (PLA), Poly(glycolic acid) (PGA), and their copolymers (PLGA) have been extensively investigated because of their biocompatibility and biodegradability. Nanoparticles act as potential carries for several classes of drugs such as anticancer agents, antihypertensive agents, immunomodulators, and hormones; and macromolecules such as nucleic acids, proteins, peptides, and antibodies. The options available for preparation have increased with advances in traditional methods, and many novel techniques for preparation of drug-loaded nanoparticles are being developed and refined. The various methods used for preparation of nanoparticles with their advantages and limitations have been discussed. The crux of the problem is the stability of nanoparticles after preparation, which is being addressed by freeze-drying using different classes of lyoprotectants. Nanoparticles can be designed for the site-specific delivery of drugs. The targeting capability of nanoparticles is influenced by particle size, surface charge, surface modification, and hydrophobicity. Finally, the performance of nanoparticles in vivo is influenced by morphological characteristics, surface chemistry, and molecular weight. Careful design of these delivery systems with respect to target and route of administration may solve some of the problems faced by new classes of active molecules.


Articles with similar content:

Functional Polymeric Nanoparticles: An Efficient and Promising Tool for Active Delivery of Bioactives
Critical Reviews™ in Therapeutic Drug Carrier Systems, Vol.23, 2006, issue 4
Senthilkumar Murugesan, Tathagata Dutta, Abhay Asthana, Manoj Tare, Surbhi Saraf, Narendra Kumar Jain, Vijayaraj Rajkumar, Manoj Nahar, Dinesh Mishra
Nanostructured Materials in Drug and Gene Delivery: A Review of the State of the Art
Critical Reviews™ in Therapeutic Drug Carrier Systems, Vol.28, 2011, issue 2
Krutika Sawant, Kailash C. Petkar, Sandip S. Chavhan, Snezana Agatonovik-Kustrin
Lipid Nanocarriers: Influence of Lipids on Product Development and Pharmacokinetics
Critical Reviews™ in Therapeutic Drug Carrier Systems, Vol.28, 2011, issue 4
Lav Keshri, Mayank Shah, Kamla Pathak
Peptide and Protein Delivery Using New Drug Delivery Systems
Critical Reviews™ in Therapeutic Drug Carrier Systems, Vol.30, 2013, issue 4
Ashish Jain, Satish Shilpi, Pooja Hurkat, Aviral Jain, Arvind Gulbake, Sanjay Kumar Jain
Polymer-Drug Conjugates for Anticancer Drug Delivery
Critical Reviews™ in Therapeutic Drug Carrier Systems, Vol.32, 2015, issue 3
Saurabh Wadhwa , Russell J. Mumper