图书馆订阅: Guest
医药载体系统评论综述

每年出版 6 

ISSN 打印: 0743-4863

ISSN 在线: 2162-660X

The Impact Factor measures the average number of citations received in a particular year by papers published in the journal during the two preceding years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) IF: 2.7 To calculate the five year Impact Factor, citations are counted in 2017 to the previous five years and divided by the source items published in the previous five years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) 5-Year IF: 3.6 The Immediacy Index is the average number of times an article is cited in the year it is published. The journal Immediacy Index indicates how quickly articles in a journal are cited. Immediacy Index: 0.8 The Eigenfactor score, developed by Jevin West and Carl Bergstrom at the University of Washington, is a rating of the total importance of a scientific journal. Journals are rated according to the number of incoming citations, with citations from highly ranked journals weighted to make a larger contribution to the eigenfactor than those from poorly ranked journals. Eigenfactor: 0.00023 The Journal Citation Indicator (JCI) is a single measurement of the field-normalized citation impact of journals in the Web of Science Core Collection across disciplines. The key words here are that the metric is normalized and cross-disciplinary. JCI: 0.39 SJR: 0.42 SNIP: 0.89 CiteScore™:: 5.5 H-Index: 79

Indexed in

Modeling of Drug Release from Polymeric Delivery Systems—A Review

卷 21, 册 5, 2004, 42 pages
DOI: 10.1615/CritRevTherDrugCarrierSyst.v21.i5.10
Get accessGet access

摘要

Polymeric drug delivery platforms have been receiving increasing attention in the past decade. The pharmaceutical industry is evaluating modes of delivery for their prized therapeutics at every step of the design cycle. Not only can the drug delivery platform transport drug molecules effectively, it can also improve patient compliance, offer greater patient convenience, and extend product lifecycles as patents expire. A large number of successful drug delivery systems have been developed as a result of an almost arbitrary selection of constituents and configurations. However, the development of advanced drug delivery systems relies on a judicious and careful selection of components, configurations, and geometries, which can be facilitated through mathematical modeling of controlled release systems. Mathematical modeling aids in predicting the drug release rates and diffusion behavior from these systems by the solution of an appropriate model, thereby reducing the number of experiments needed. It also aids in understanding the physics of a particular drug transport phenomenon, thus facilitating the development of new pharmaceutical products. The objective of this article is to review the spectrum of mathematical models that have been developed to describe drug release from polymeric controlled release systems. The mathematical models presented in this article have been grouped under diffusion controlled systems, swelling controlled systems, and erosion controlled systems as proposed by Langer and Peppas.2,3 Simple empirical or semi-empirical models and complex mechanistic model that consider diffusion, swelling, and erosion processes simultaneously are presented.

对本文的引用
  1. Parveen Suphiya, Sahoo Sanjeeb K, Nanomedicine, Clinical Pharmacokinetics, 45, 10, 2006. Crossref

  2. Karakosta E., McDonald P. J., An MRI Analysis of the Dissolution of a Soluble Drug Incorporated within an Insoluble Polymer Tablet, Applied Magnetic Resonance, 32, 1-2, 2007. Crossref

  3. AlKhatib Hatim S., Hamed Saja, Mohammad Mohammad K., Bustanji Yasser, AlKhalidi Bashar, Aiedeh Khaled M., Najjar Samer, Effects of Thermal Curing Conditions on Drug Release from Polyvinyl Acetate–Polyvinyl Pyrrolidone Matrices, AAPS PharmSciTech, 11, 1, 2010. Crossref

  4. Matero Sanni, Reinikainen Satu-Pia, Lahtela-Kakkonen Maija, Korhonen Ossi, Ketolainen Jarkko, Poso Antti, Estimation of drug release profiles of a heterogeneous set of drugs from a hydrophobic matrix tablet using molecular descriptors, Journal of Chemometrics, 22, 11-12, 2008. Crossref

  5. Chakravarthi Sudhir S., Robinson Dennis H., Biodegradable Nanoparticles, in Pharmaceutical Sciences Encyclopedia, 2010. Crossref

  6. Tavera Enrique Muñoz, Kadali Shyam B., Bagaria Hitesh G., Liu Amy W., Wong Michael S., Experimental and modeling analysis of diffusive release from single-shell microcapsules, AIChE Journal, 55, 11, 2009. Crossref

  7. Prokop Ales, Davidson Jeffrey M., Nanovehicular Intracellular Delivery Systems, Journal of Pharmaceutical Sciences, 97, 9, 2008. Crossref

  8. Cheng Felice, Choy Young Bin, Choi Hyungsoo, Kim Kyekyoon (Kevin), Modeling of small-molecule release from crosslinked hydrogel microspheres: Effect of crosslinking and enzymatic degradation of hydrogel matrix, International Journal of Pharmaceutics, 403, 1-2, 2011. Crossref

  9. Lin Chien-Chi, Metters Andrew T., Hydrogels in controlled release formulations: Network design and mathematical modeling, Advanced Drug Delivery Reviews, 58, 12-13, 2006. Crossref

  10. Viridén Anna, Abrahmsén-Alami Susanna, Wittgren Bengt, Larsson Anette, Release of theophylline and carbamazepine from matrix tablets – Consequences of HPMC chemical heterogeneity, European Journal of Pharmaceutics and Biopharmaceutics, 78, 3, 2011. Crossref

  11. Harth Karem C., Rosen Michael J., Thatiparti Thimma R., Jacobs Michael R., Halaweish Ihab, Bajaksouzian Saralee, Furlan Joseph, von Recum Horst A., Antibiotic-Releasing Mesh Coating to Reduce Prosthetic Sepsis: An In Vivo Study, Journal of Surgical Research, 163, 2, 2010. Crossref

  12. Lee Yan Sim, Lowe John P., Gilby Ed, Perera Semali, Rigby Sean P., The initial release of cisplatin from poly(lactide-co-glycolide) microspheres, International Journal of Pharmaceutics, 383, 1-2, 2010. Crossref

  13. Pitt William G., Jack Daniel R., Zhao Yibei, Nelson Jared L., Pruitt John D., Loading and Release of a Phospholipid From Contact Lenses, Optometry and Vision Science, 88, 4, 2011. Crossref

  14. Adibkia Khosro, Hamedeyazdan Sanaz, Javadzadeh Yousef, Drug release kinetics and physicochemical characteristics of floating drug delivery systems, Expert Opinion on Drug Delivery, 8, 7, 2011. Crossref

  15. Vlugt-Wensink Karin D.F., Vlugt Thijs J.H., Jiskoot Wim, Crommelin Daan J.A., Verrijk Ruud, Hennink Wim E., Modeling the release of proteins from degrading crosslinked dextran microspheres using kinetic Monte Carlo simulations, Journal of Controlled Release, 111, 1-2, 2006. Crossref

  16. Adnadjevic B., Jovanovic J., A comparative kinetics study of isothermal drug release from poly(acrylic acid) and poly(acrylic-co-methacrylic acid) hydrogels, Colloids and Surfaces B: Biointerfaces, 69, 1, 2009. Crossref

  17. Hamidi Mehrdad, Azadi Amir, Rafiei Pedram, Hydrogel nanoparticles in drug delivery, Advanced Drug Delivery Reviews, 60, 15, 2008. Crossref

  18. Viridén Anna, Wittgren Bengt, Andersson Thomas, Larsson Anette, The effect of chemical heterogeneity of HPMC on polymer release from matrix tablets, European Journal of Pharmaceutical Sciences, 36, 4-5, 2009. Crossref

  19. Carvalho Joana M., Coimbra Manuel A., Gama Francisco M., New dextrin-vinylacrylate hydrogel: Studies on protein diffusion and release, Carbohydrate Polymers, 75, 2, 2009. Crossref

  20. Viridén Anna, Wittgren Bengt, Larsson Anette, Investigation of critical polymer properties for polymer release and swelling of HPMC matrix tablets, European Journal of Pharmaceutical Sciences, 36, 2-3, 2009. Crossref

  21. Mehta Manav, Schmidt-Bleek Katharina, Duda Georg N., Mooney David J., Biomaterial delivery of morphogens to mimic the natural healing cascade in bone, Advanced Drug Delivery Reviews, 64, 12, 2012. Crossref

  22. Yadav Kiran, Yadav Deepak, Srivastava Anand Kumar, Evaluation of hydrophilic, hydrophobic and waxy matrix excipients for sustained release tablets of Venlafaxine hydrochloride, Drug Development and Industrial Pharmacy, 39, 8, 2013. Crossref

  23. Tamasi Gabriella, Casolaro Mario, Cini Renzo, X-ray structure and computational study for N-acryloyl-l-valine, a versatile monomer for preparing smart drug delivery carriers, Journal of Molecular Structure, 1029, 2012. Crossref

  24. Hamidi Mehrdad, Ashrafi Hajar, Azadi Amir, Surface Functionalized Hydrogel Nanoparticles, in Biomedical Materials and Diagnostic Devices, 2012. Crossref

  25. Barry Steven I., Caunce James, Exact and numerical solutions to a Stefan problem with two moving boundaries, Applied Mathematical Modelling, 32, 1, 2008. Crossref

  26. Ford Versypt Ashlee N., Pack Daniel W., Braatz Richard D., Mathematical modeling of drug delivery from autocatalytically degradable PLGA microspheres — A review, Journal of Controlled Release, 165, 1, 2013. Crossref

  27. Ražem Dušan, Katušin-Ražem Branka, The effects of irradiation on controlled drug delivery/controlled drug release systems, Radiation Physics and Chemistry, 77, 3, 2008. Crossref

  28. Lu S.M., Chang Szu-Lin, Ku Wen-Yu, Chang Hou-Chien, Wang Jiunn-Yau, Lee Duu-Jong, Urea release rate from a scoop of coated pure urea beads: Unified extreme analysis, Journal of the Chinese Institute of Chemical Engineers, 38, 3-4, 2007. Crossref

  29. Pitt William G., Jack Daniel R., Zhao Yibei, Nelson Jared L., Pruitt John D., Transport of Phospholipid in Silicone Hydrogel Contact Lenses, Journal of Biomaterials Science, Polymer Edition, 23, 1-4, 2012. Crossref

  30. McAfee Michele S., Annunziata Onofrio, Cross-diffusion in a colloid–polymer aqueous system, Fluid Phase Equilibria, 356, 2013. Crossref

  31. Khan Wahid, Farah Shady, Nyska Abraham, Domb Abraham J., Carrier free rapamycin loaded drug eluting stent: In vitro and in vivo evaluation, Journal of Controlled Release, 168, 1, 2013. Crossref

  32. Farah Shady, Khan Wahid, Domb Abraham J., Crystalline coating of rapamycin onto a stent: Process development and characterization, International Journal of Pharmaceutics, 445, 1-2, 2013. Crossref

  33. Minelli Matteo, Doghieri Ferruccio, Predictive model for gas and vapor solubility and swelling in glassy polymers I: Application to different polymer/penetrant systems, Fluid Phase Equilibria, 381, 2014. Crossref

  34. Good Clinical Practice, in Handbook of Bioequivalence Testing, 2014. Crossref

  35. Linderman Jennifer J., Cilfone Nicholas A., Pienaar Elsje, Gong Chang, Kirschner Denise E., A multi-scale approach to designing therapeutics for tuberculosis, Integrative Biology, 7, 5, 2015. Crossref

  36. Das Dipankar, Pal Sagar, Modified biopolymer-dextrin based crosslinked hydrogels: application in controlled drug delivery, RSC Advances, 5, 32, 2015. Crossref

  37. Amiryousefi Mohammad Reza, Mohebbi Mohebbat, Golmohammadzadeh Shiva, Koocheki Arash, Encapsulation of caffeine in hydrogel colloidosome: optimization of fabrication, characterization and release kinetics evaluation, Flavour and Fragrance Journal, 31, 2, 2016. Crossref

  38. Shenderovich Julia, Feldman Mark, Kirmayer David, Al-Quntar Abed, Steinberg Doron, Lavy Eran, Friedman Michael, Local sustained-release delivery systems of the antibiofilm agent thiazolidinedione-8 for prevention of catheter-associated urinary tract infections, International Journal of Pharmaceutics, 485, 1-2, 2015. Crossref

  39. Grin A., Moor E., Friedman M., Sustained release of doxycycline as matrix metalloproteinase inhibitor for treatment of chronic periodontal diseases: in vitro evaluation, Journal of Drug Delivery Science and Technology, 19, 4, 2009. Crossref

  40. Maver T., Kurečič M., Smrke D. M., Kleinschek K. Stana, Maver U., Electrospun nanofibrous CMC/PEO as a part of an effective pain-relieving wound dressing, Journal of Sol-Gel Science and Technology, 79, 3, 2016. Crossref

  41. Abdel-Hafez Mamoun, Husseini Ghaleb A., Predicting the Release of Chemotherapeutics From the Core of Polymeric Micelles Using Ultrasound, IEEE Transactions on NanoBioscience, 14, 4, 2015. Crossref

  42. Jasso-Gastinel Carlos Federico, Gradients in Polymers, in Encyclopedia of Biomedical Polymers and Polymeric Biomaterials, 2015. Crossref

  43. Kwon Soon Sik, Kong Bong Ju, Park Soo Nam, Physicochemical properties of pH-sensitive hydrogels based on hydroxyethyl cellulose–hyaluronic acid and for applications as transdermal delivery systems for skin lesions, European Journal of Pharmaceutics and Biopharmaceutics, 92, 2015. Crossref

  44. Bunker Alex, Molecular Modeling as a Tool to Understand the Role of Poly(Ethylene) Glycol in Drug Delivery, in Computational Pharmaceutics, 2015. Crossref

  45. Cilfone NA, Pienaar E, Thurber GM, Kirschner DE, Linderman JJ, Systems Pharmacology Approach Toward the Design of Inhaled Formulations of Rifampicin and Isoniazid for Treatment of Tuberculosis, CPT: Pharmacometrics & Systems Pharmacology, 4, 3, 2015. Crossref

  46. Chan Lai Wah, Ching Ai Ling, Liew Celine Valeria, Heng Paul Wan Sia, Mechanistic Study on Hydration and Drug Release Behavior of Sodium Alginate Compacts, Drug Development and Industrial Pharmacy, 33, 6, 2007. Crossref

  47. Bunker Alex, Magarkar Aniket, Viitala Tapani, Rational design of liposomal drug delivery systems, a review: Combined experimental and computational studies of lipid membranes, liposomes and their PEGylation, Biochimica et Biophysica Acta (BBA) - Biomembranes, 1858, 10, 2016. Crossref

  48. Gefter (Shenderovich) Julia, Zaks Batya, Kirmayer David, Lavy Eran, Steinberg Doron, Friedman Michael, Chlorhexidine sustained-release varnishes for catheter coating – Dissolution kinetics and antibiofilm properties, European Journal of Pharmaceutical Sciences, 112, 2018. Crossref

  49. Saudi Muhamad Hakimi, Mahali Shalela Mohd, Harun Fatimah Noor, The analytical solution for drug delivery system with nonhomogeneous moving boundary condition, 1870, 2017. Crossref

  50. Majumder Arnab, Scott Jeffrey R., Novitsky Yuri W., Evaluation of the Antimicrobial Efficacy of a Novel Rifampin/Minocycline-Coated, Noncrosslinked Porcine Acellular Dermal Matrix Compared With Uncoated Scaffolds for Soft Tissue Repair, Surgical Innovation, 23, 5, 2016. Crossref

  51. Wadi Ali, Abdel-Hafez Mamoun, Husseini Ghaleb A., Identification of the Uncertainty Structure to Estimate the Acoustic Release of Chemotherapeutics From Polymeric Micelles, IEEE Transactions on NanoBioscience, 16, 7, 2017. Crossref

  52. Stergar Janja, Ban Irena, Gradišnik Lidija, Maver Uroš, Novel drug delivery system based on NiCu nanoparticles for targeting various cells, Journal of Sol-Gel Science and Technology, 88, 1, 2018. Crossref

  53. Feldman Mark, Shenderovich Julia, Lavy Eran, Friedman Michael, Steinberg Doron, A Sustained-Release Membrane of Thiazolidinedione-8: Effect on Formation of a Candida/Bacteria Mixed Biofilm on Hydroxyapatite in a Continuous Flow Model, BioMed Research International, 2017, 2017. Crossref

  54. Farah Shady, Domb Abraham J., Crystalline paclitaxel coated DES with bioactive protective layer development, Journal of Controlled Release, 271, 2018. Crossref

  55. Villanova Janaina C. O., Oréfice Rodrigo L., Cunha Armando S., Aplicações farmacêuticas de polímeros, Polímeros, 20, 1, 2010. Crossref

  56. Moscovici Misu, Hlevca Cristina, Casarica Angela, Pavaloiu Ramona-Daniela, Nanocellulose and Nanogels as Modern Drug Delivery Systems, in Nanocellulose and Nanohydrogel Matrices, 2017. Crossref

  57. Raza Faisal, Zafar Hajra, Zhu Ying, Ren Yuan, -Ullah Aftab, Khan Asif, He Xinyi, Han Han, Aquib Md, Boakye-Yiadom Kofi, Ge Liang, A Review on Recent Advances in Stabilizing Peptides/Proteins upon Fabrication in Hydrogels from Biodegradable Polymers, Pharmaceutics, 10, 1, 2018. Crossref

  58. Levina Marina, Rajabi-Siahboomi Ali R., An Industrial Perspective on Hydrophilic Matrix Tablets Based on Hyproxypropyl Methylcellulose (Hypromellose), in Hydrophilic Matrix Tablets for Oral Controlled Release, 16, 2014. Crossref

  59. Huang Haiqin, Qi Xiaole, Chen Yanhua, Wu Zhenghong, Thermo-sensitive hydrogels for delivering biotherapeutic molecules: A review, Saudi Pharmaceutical Journal, 27, 7, 2019. Crossref

  60. Shen Lanbo, Gao Na, Huang Xirong, Synthesis, characterization and electropolymerization of functionalized organic salt–anilinium saccharinate and electrochemically controlled release of saccharinate anions, Electrochimica Acta, 329, 2020. Crossref

  61. Subrizi Astrid, del Amo Eva M., Korzhikov-Vlakh Viktor, Tennikova Tatiana, Ruponen Marika, Urtti Arto, Design principles of ocular drug delivery systems: importance of drug payload, release rate, and material properties, Drug Discovery Today, 24, 8, 2019. Crossref

  62. Freitas Emanuelle D., Vidart Jacyara M.M., da Silva Meuris G.C., Vieira Melissa G.A., Thermal characterization and stability investigation of sericin and alginate blend loaded with diclofenac sodium or ibuprofen, European Polymer Journal, 142, 2021. Crossref

  63. Freitas Emanuelle D., Freitas Vitória M.S., Rosa Paulo C.P., da Silva Meuris G.C., Vieira Melissa G.A., Development and evaluation of naproxen-loaded sericin/alginate beads for delayed and extended drug release using different covalent crosslinking agents, Materials Science and Engineering: C, 118, 2021. Crossref

  64. Annunziata Onofrio, Buzatu Daniela, Albright John G., Protein Diffusiophoresis and Salt Osmotic Diffusion in Aqueous Solutions, The Journal of Physical Chemistry B, 116, 42, 2012. Crossref

  65. Hou Jia, Sun Xiaoyan, Huang Ying, Yang Shaohua, Liu Junjie, Feng Changhao, Ma Jun, Chen Bin, The Design and Application of Nanomaterials as Drug Carriers in Cancer Treatment, Current Medicinal Chemistry, 27, 36, 2020. Crossref

  66. McAfee Michele S., Zhang Huixiang, Annunziata Onofrio, Amplification of Salt-Induced Polymer Diffusiophoresis by Increasing Salting-Out Strength, Langmuir, 30, 41, 2014. Crossref

  67. Ehsanimehr Sedigheh, Najafi Moghadam Peyman, Dehaen Wim, Shafiei-Irannejad Vahid, Synthesis of pH-sensitive nanocarriers based on polyacrylamide grafted nanocrystalline cellulose for targeted drug delivery to folate receptor in breast cancer cells, European Polymer Journal, 150, 2021. Crossref

  68. Gao Yu, Chen Yu, Ji Xiufeng, He Xinyu, Yin Qi, Zhang Zhiwen, Shi Jianlin, Li Yaping, Controlled Intracellular Release of Doxorubicin in Multidrug-Resistant Cancer Cells by Tuning the Shell-Pore Sizes of Mesoporous Silica Nanoparticles, ACS Nano, 5, 12, 2011. Crossref

  69. Zhang Huixiang, Annunziata Onofrio, Diffusion of an Ionic Drug in Micellar Aqueous Solutions, Langmuir, 25, 6, 2009. Crossref

  70. Minelli Matteo, Sarti Giulio C., 110th Anniversary: Gas and Vapor Sorption in Glassy Polymeric Membranes—Critical Review of Different Physical and Mathematical Models, Industrial & Engineering Chemistry Research, 59, 1, 2020. Crossref

  71. Farah Shady, Protective Layer Development for Enhancing Stability and Drug-Delivery Capabilities of DES Surface-Crystallized Coatings, ACS Applied Materials & Interfaces, 10, 10, 2018. Crossref

  72. Minelli Matteo, Doghieri Ferruccio, A Predictive Model for Vapor Solubility and Volume Dilation in Glassy Polymers, Industrial & Engineering Chemistry Research, 51, 50, 2012. Crossref

  73. Zhang Huixiang, Annunziata Onofrio, Modulation of Drug Transport Properties by Multicomponent Diffusion in Surfactant Aqueous Solutions, Langmuir, 24, 19, 2008. Crossref

  74. Enwereuzo Onyekachi Oluchi, Akakuru Obinna Chigoziem, Uwaoma Romanus Chinonso, Elemike Elias Emeka, Akakuru Ozioma Udochukwu, Self-assembled membrane-polymer nanoparticles of top-notch tissue tolerance for the treatment of gastroesophageal reflux disease, Journal of Nanostructure in Chemistry, 11, 4, 2021. Crossref

  75. Hathout Rania M., Metwally AbdelKader A., Woodman Timothy J., Hardy John G., Prediction of Drug Loading in the Gelatin Matrix Using Computational Methods, ACS Omega, 5, 3, 2020. Crossref

  76. McAfee Michele S., Annunziata Onofrio, Effect of Particle Size on Salt-Induced Diffusiophoresis Compared to Brownian Mobility, Langmuir, 30, 17, 2014. Crossref

  77. Akakuru Ozioma Udochukwu, Onyido Ikenna, Controlled Release Formulations of 2,4-Dichlorophenoxyacetic Acid with Ecofriendly Matrices for Agricultural and Environmental Sustainability, Macromolecular Research, 29, 1, 2021. Crossref

  78. Heredia Nathaly S., Vizuete Karla, Flores-Calero Marco, Pazmiño V. Katherine, Pilaquinga Fernanda, Kumar Brajesh, Debut Alexis, Annamalai Pratheep K., Comparative statistical analysis of the release kinetics models for nanoprecipitated drug delivery systems based on poly(lactic-co-glycolic acid), PLOS ONE, 17, 3, 2022. Crossref

  79. Park Jung-Hwan, Allen Mark G., Prausnitz Mark R., Polymer Microneedles for Controlled-Release Drug Delivery, Pharmaceutical Research, 23, 5, 2006. Crossref

  80. Jin Xin, Wei Chengxiong, Wu Chengwei, Zhang Wei, Gastroretentive core–shell hydrogel assembly for sustained release of metformin hydrochloride, European Polymer Journal, 170, 2022. Crossref

  81. Manjula B., Reddy A. Babul, Jayaramudu T., Sadiku E.R., Owonubi S.J., Owonubi S.J., Agboola Oluranti, Agboola Oluranti, Agboola Oluranti, Mokrani Tauhami, Hydrogels and its Nanocomposites from Renewable Resources: Biotechnological and Biomedical Applications, in Handbook of Composites from Renewable Materials, 2017. Crossref

  82. Garshasbi Morteza, Bagomghaleh Shadi Malek, Investigation of a Drug Release Moving Boundary Problem in a Swelling Polymeric Device, International Journal of Applied and Computational Mathematics, 8, 2, 2022. Crossref

  83. Tundisi L.L., Mostaço G.B., Carricondo P.C., Petri D.F.S., Hydroxypropyl methylcellulose: Physicochemical properties and ocular drug delivery formulations, European Journal of Pharmaceutical Sciences, 159, 2021. Crossref

  84. Feldman Mark, Gati Irith, Sionov Ronit Vogt, Sahar-Helft Sharonit, Friedman Michael, Steinberg Doron, Potential Combinatory Effect of Cannabidiol and Triclosan Incorporated into Sustained Release Delivery System against Oral Candidiasis, Pharmaceutics, 14, 8, 2022. Crossref

  85. Chavan Y.R., Tambe S.M., Jain D.D., Khairnar S.V., Amin P.D., Redefining the importance of polylactide-co-glycolide acid (PLGA) in drug delivery, Annales Pharmaceutiques Françaises, 80, 5, 2022. Crossref

Begell Digital Portal Begell 数字图书馆 电子图书 期刊 参考文献及会议录 研究收集 订购及政策 Begell House 联系我们 Language English 中文 Русский Português German French Spain