图书馆订阅: Guest
Begell Digital Portal Begell 数字图书馆 电子图书 期刊 参考文献及会议录 研究收集
医药载体系统评论综述
影响因子: 2.9 5年影响因子: 3.72 SJR: 0.573 SNIP: 0.551 CiteScore™: 2.43

ISSN 打印: 0743-4863
ISSN 在线: 2162-660X

医药载体系统评论综述

DOI: 10.1615/CritRevTherDrugCarrierSyst.2018025649
pages 137-181

Long-Acting Injectables: Current Perspectives and Future Promise

Komal Chaudhary
Institute of Pharmacy, Nirma University, Ahmedabad, Gujarat, India
Mayur M. Patel
Institute of Pharmacy, Nirma University, Ahmedabad, Gujarat, India
Priti J. Mehta
Institute of Pharmacy, Nirma University, Ahmedabad, Gujarat, India

ABSTRACT

The parenteral route of administration is preferred over the oral route for treatment of many chronic and life-threatening diseases due to better patient compliance. Long-acting injectables/depot delivery systems are formulations intended for prolonged/sustained drug release over a long period of time ranging from a few days to months. Depot delivery systems enhance product quality by decreasing dosing frequency, simplifying the drug regimen. Parenteral depots reduce the relapse rate of disease and the maintenance phase of therapy, hence improving efficacy and treatment adherence. However, despite being extensively explored in the last seventy years, only a few depot products have been marketed or have reached commercial viability. The introduction of long-acting injectables of any drug took 9 to 10 years after approval of its oral formulation. Mainly the market has been conquered by long-acting injectables for antipsychotic, substance abuse, and hormonal therapy drugs.
This article focuses on the preparation of long-acting injectables with special emphasis on challenges associated with formulation. The evolution and current global market trend of various depot formulations are also discussed. Insight is provided into the promising future of long-acting injectables of protein-based drugs as well as multidrug therapy, along with potential uses in the treatment of chronic diseases like HIV, Parkinson's, and Alzheimer's.


Articles with similar content:

Oral Absorption Promoters: Opportunities, Issues, and Challenges
Critical Reviews™ in Therapeutic Drug Carrier Systems, Vol.32, 2015, issue 5
Sushilkumar Patil, Girish Kore, Atul Kolate, Chetan Yewale, Ambikanandan Misra
Oral Controlled-Release Formulation in Veterinary Medicine
Critical Reviews™ in Therapeutic Drug Carrier Systems, Vol.23, 2006, issue 3
Stefan Soback, Eran Lavy, Amir Steinman
Perspectives of Lipid-Based Drug Carrier Systems for Transdermal Delivery
Critical Reviews™ in Therapeutic Drug Carrier Systems, Vol.35, 2018, issue 4
Shikha Srivastava, Madhulika Pradhan, Shailendra Saraf, Deependra Singh, Swarnlata Saraf, Manju Rawat Singh
Oral Delivery of HIV-Protease Inhibitors
Critical Reviews™ in Therapeutic Drug Carrier Systems, Vol.17, 2000, issue 2
Barbra H. Stewart, Lilian Y. Li, David Fleisher
Cancer Chemotherapy With Lipid-Based Nanocarriers
Critical Reviews™ in Therapeutic Drug Carrier Systems, Vol.27, 2010, issue 5
Na Zhang, Donghua Liu