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ISSN 打印: 0743-4863

ISSN 在线: 2162-660X

The Impact Factor measures the average number of citations received in a particular year by papers published in the journal during the two preceding years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) IF: 2.7 To calculate the five year Impact Factor, citations are counted in 2017 to the previous five years and divided by the source items published in the previous five years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) 5-Year IF: 3.6 The Immediacy Index is the average number of times an article is cited in the year it is published. The journal Immediacy Index indicates how quickly articles in a journal are cited. Immediacy Index: 0.8 The Eigenfactor score, developed by Jevin West and Carl Bergstrom at the University of Washington, is a rating of the total importance of a scientific journal. Journals are rated according to the number of incoming citations, with citations from highly ranked journals weighted to make a larger contribution to the eigenfactor than those from poorly ranked journals. Eigenfactor: 0.00023 The Journal Citation Indicator (JCI) is a single measurement of the field-normalized citation impact of journals in the Web of Science Core Collection across disciplines. The key words here are that the metric is normalized and cross-disciplinary. JCI: 0.39 SJR: 0.42 SNIP: 0.89 CiteScore™:: 5.5 H-Index: 79

Indexed in

Steroid Receptors as Molecular Targets for Cancer Diagnosis and Therapy

卷 26, 册 3, 2009, pp. 207-273
DOI: 10.1615/CritRevTherDrugCarrierSyst.v26.i3.10
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摘要

The targeted delivery of chemotherapeutics is essential to minimizing the side effects by sparing the normal tissues by exposure to cytotoxic agents. The various receptors are overexpressed on the surface of the tumor tissues as compared to the normal tissues because their requirement for various essential components is high for the growth and development of tumor tissues. These overexpressed receptors on the tumor surface have been investigated for selective delivery of imaging, cytotoxic, or other therapeutic agents. Hormonal receptors viz. peptide and steroid receptors (SRs), which are present over the tumor surface, are also used for tumor targeting of various molecules for therapeutic use or imaging purpose. The key role of SRs is in the transactivation step of protein synthesis and to maintain the homeostasis in normal and diseased states. These receptors are overactivated in different diseases, including tumorigenesis. Hence, these SRs may act as a potential target for selective delivery of different therapeutic or cytotoxic agents. The selective delivery of these agents may be a better treatment strategy for endocrine cancer because it results in cytosolic and nuclear delivery of cytotoxic agents as well. The objective of the present review is to explore the importance of sex SRs as a vital target in endocrine cancer therapy. Potential strategies investigated for the delivery of imaging agents, chemotherapeutics, and toxins via steroidal ligands have been discussed. The importance of gene therapy in different diseases, including endocrine cancer, is well defined; thus, some effective gene delivery approaches investigated in endocrine cancer via steroidal ligands have also been discussed.

对本文的引用
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  2. Wängler Björn, Schirrmacher Ralf, Wängler Carmen, Aiming at the tumor-specific accumulation of MGMT-inhibitors: First description of a synthetic strategy towards inhibitor-peptide conjugates, Tetrahedron Letters, 61, 19, 2020. Crossref

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  4. Jain Sanjay K, Jain Ashish, Gulbake Arvind, Shilpi Satish, Khare Piush, Steroid-coupled liposomes for targeted delivery to tumor, Therapeutic Delivery, 1, 2, 2010. Crossref

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