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医药载体系统评论综述
影响因子: 2.9 5年影响因子: 3.72 SJR: 0.736 SNIP: 0.551 CiteScore™: 2.43

ISSN 打印: 0743-4863
ISSN 在线: 2162-660X

医药载体系统评论综述

DOI: 10.1615/CritRevTherDrugCarrierSyst.2017020147
pages 551-587

Expanding the domain of drug delivery for HIV prevention: exploration of the transdermal route

Ashana Puri
Department of Pharmaceutical Sciences, College of Pharmacy, Mercer University, Atlanta, GA
Arunprasad Sivaraman
Department of Pharmaceutical Sciences, College of Pharmacy, Mercer University, Atlanta, GA
Wei Zhang
CONRAD, Department of Obstetrics and Gynecology, Eastern Virginia Medical School, Arlington, VA
Meredith R. Clark
CONRAD, Department of Obstetrics and Gynecology, Eastern Virginia Medical School, Arlington, VA
Ajay K. Banga
Department of Pharmaceutical Sciences, College of Pharmacy and Health Sciences, Mercer University, Atlanta, GA, USA

ABSTRACT

Constant efforts for HIV prevention using antiretroviral drugs, pre- and postexposure prophylactic agents, and microbicides are being made by researchers. Drug-delivery systems such as oral tablets and coitally dependent vaginal gels are short acting, require daily application, and are associated with user adherence issues, whereas the coitally independent systems such as injectables and biodegradable implants are long acting, lasting several months, during which time the termination of prophylaxis is impractical in case of adverse effects. An effective drug-delivery system to be used for an intermediate duration, if available, would be an attractive alternative option for users in terms of adherence. Transdermal delivery systems, overcoming most of the limitations of the other routes of administration and aiming to provide sustained delivery of drugs through skin, may be explored for HIV prevention. Passive and physical enhancement techniques may be designed strategically to improve the transdermal delivery of HIV preventive agents.


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