每年出版 6 期
ISSN 打印: 0743-4863
ISSN 在线: 2162-660X
Indexed in
Lipids and Surfactants: The Inside Story of Lipid-Based Drug Delivery Systems
摘要
In the bioavailability enhancement of poorly aqueous soluble drugs, self-emulsifying/microemulsifying drug delivery systems (SEDDS/SMEDDS) are isotropic mixtures of oils, surfactants, solvents, and cosolvents/surfactants that have gained immense popularity because of their self-emulsification ability. This characteristic relies on some critical parameters such as surfactant concentration, oil-to-surfactant ratio, polarity of the emulsion, droplet size and charge, which are acquired from an amalgamation of appropriate excipients. The fabrication of this combination is of utmost importance for formulation scientists. Hence, to explore the potential of such a delivery system, standardized guidelines for excipients must be developed to address bioavailability issues. In the present review, we summarize the approaches to selecting the most suitable lipid(s)-based drug delivery system, including characterization, especially for oral delivery, of both physicochemical and biopharmaceutical aspects and properties of assorted excipients as well as the related patent reports.
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Zhang Qi, Guo Kunkun, Wang Xin, Huang Baolin, Lin Zimin, Cai Zheng, Optimization of lipid materials in the formulation of S-carvedilol self-microemulsifying drug-delivery systems, Drug Development and Industrial Pharmacy, 46, 9, 2020. Crossref
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Karavasili Christina, Andreadis Ioannis I., Tsantarliotou Maria P., Taitzoglou Ioannis A., Chatzopoulou Paschalina, Katsantonis Dimitrios, Zacharis Constantinos K., Markopoulou Catherine, Fatouros Dimitrios G., Self-Nanoemulsifying Drug Delivery Systems (SNEDDS) Containing Rice Bran Oil for Enhanced Fenofibrate Oral Delivery: In Vitro Digestion, Ex Vivo Permeability, and In Vivo Bioavailability Studies, AAPS PharmSciTech, 21, 6, 2020. Crossref
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Ren Yanru, Feng Yicheng, Xu Kunyao, Yue Saisai, Yang Tiantian, Nie Kaili, Xu Man, Xu Haijun, Xiong Xin, Körte Fabian, Barbeck Mike, Zhang Peisen, Liu Luo, Enhanced Bioavailability of Dihydrotanshinone I–Bovine Serum Albumin Nanoparticles for Stroke Therapy, Frontiers in Pharmacology, 12, 2021. Crossref
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Nayak Amit Kumar, Hasnain Md Saquib, Behera Anindita, Dhara Amal Kumar, Pal Dilipkumar, Biological macromolecules in drug delivery, in Biological Macromolecules, 2022. Crossref
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Mirgorodskaya A. B., Kushnazarova R. A., Lukashenko S. S., Zakharova L. Ya., Mixed Micellar Solutions of Hexadecylpiperidinium Surfactants and Tween 80: Aggregation Behavior and Solubilizing Properties, Russian Journal of Physical Chemistry A, 94, 9, 2020. Crossref
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Dhara Amal Kumar, Nayak Amit Kumar, Biological macromolecules: sources, properties, and functions, in Biological Macromolecules, 2022. Crossref
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Almeida Furquim de Camargo Bruna, Fonseca-Santos Bruno, Gonçalves Carvalho Suzana, Corrêa Carvalho Gabriela, Delello Di Filippo Leonardo, Sousa Araújo Victor Hugo, Lobato Duarte Jonatas, Polli Silvestre Amanda Letícia, Bauab Taís Maria, Chorilli Marlus, Functionalized lipid-based drug delivery nanosystems for the treatment of human infectious diseases, Critical Reviews in Microbiology, 2022. Crossref
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Kadukkattil Ramanunny Arya, Singh Sachin Kumar, Wadhwa Sheetu, Gulati Monica, Kapoor Bhupinder, Khursheed Rubiya, Kuppusamy Gowthamarajan, Dua Kamal, Dureja Harish, Chellappan Dinesh Kumar, Jha Niraj Kumar, Gupta Piyush Kumar, Vishwas Sukriti, Overcoming hydrolytic degradation challenges in topical delivery: non-aqueous nano-emulsions, Expert Opinion on Drug Delivery, 19, 1, 2022. Crossref
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Dhaval Mori, Vaghela Poonam, Patel Kajal, Sojitra Keshvi, Patel Mohini, Patel Sushma, Dudhat Kiran, Shah Sunny, Manek Ravi, Parmar Ramesh, Lipid-based emulsion drug delivery systems — a comprehensive review, Drug Delivery and Translational Research, 12, 7, 2022. Crossref
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Nie Dengyun, Guo Ting, Yue Miao, Li Wenya, Zong Xinyu, Zhu Yinxing, Huang Junxing, Lin Mei, Research Progress on Nanoparticles-Based CRISPR/Cas9 System for Targeted Therapy of Tumors, Biomolecules, 12, 9, 2022. Crossref
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Earle R.R., Gadela V.R., Optimization and characterization of self-nanoemulsifying drug delivery system of iloperidone using box-behnken design and desirability function, Annales Pharmaceutiques Françaises, 2022. Crossref
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Betterelli Giuliano Camila, Moran Joseph, Ayache Jessica, Muiznieks Lisa, Stability characterization of microfluidics lipid-stabilized double emulsions under physiologically-relevant conditions, Open Research Europe, 2, 2022. Crossref
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Jin Zhiyu, Han Yu, Zhang Danshen, Li Zhongqiu, Jing Yongshuai, Hu Beibei, Sun Shiguo, Application of Intranasal Administration in the Delivery of Antidepressant Active Ingredients, Pharmaceutics, 14, 10, 2022. Crossref