图书馆订阅: Guest
Begell Digital Portal Begell 数字图书馆 电子图书 期刊 参考文献及会议录 研究收集
肿瘤形成评论综述™
SJR: 0.631 SNIP: 0.503 CiteScore™: 2.2

ISSN 打印: 0893-9675
ISSN 在线: 2162-6448

肿瘤形成评论综述™

DOI: 10.1615/CritRevOncog.2013006061
pages 247-268

Gaucher Disease and Myeloma

Robert Ayto
Dept Haematology, North West London NHS Trust London UK
Derralynn A. Hughes
Lysosomal Storage Disorders Unit, Royal Free Campus, University College London, UK

ABSTRACT

Gaucher disease (GD), the commonest lysosomal storage disorder, is an autosomal recessive condition, caused by deficiency in lysosomal glucocerebrosidase. Skeletal disease, peripheral blood cytopenias and hepato-splenomegaly are common at presentation. Several reports describe an increased risk of cancer in GD; in particular multiple myeloma. Tumor Associated Macrophages (TAMs) may promote cancerous expansion in non-GD patients, but it is unknown whether such an occurrence is present in GD. GD is traditionally described as a disorder of macrophages, associated with numerical and functional lymphoid abnormalities which could contribute to a state of impaired 'tumor surveillance'. These abnormalities include disturbances in invariant NK-T cells that depend on sphingolipid metabolism to deliver a physiological response. Glucosylceramide deposition, chronic antigenic stimulation, increased free radical production, impaired antigen presentation, reduced intra-cellular ceramide levels and disturbed autophagy have all been postulated to facilitate the growth of malignant clones in the GD microenvironment. At present, it is unknown whether carrier status for a GBA1 mutation confers an increased risk of malignancy. A cancer diagnosis is not currently an indication for GD-specific therapy in the absence of other features of the disease This article reviews cancer epidemiology, potential biological mechanisms of carcinogenesis and highlights areas of future research regarding malignancy in GD.


Articles with similar content:

Gaucher's Disease and Cancer: A Sphingolipid Perspective
Critical Reviews™ in Oncogenesis, Vol.18, 2013, issue 3
Sriram S. Shanmugavelandy, Diana M. Tacelosky, Samy A. F. Morad, Myles C. Cabot, Mark Kester, Brian M. Barth
Gaucher Disease and Malignancy: A Model for Cancer Pathogenesis in an Inborn Error of Metabolism
Critical Reviews™ in Oncogenesis, Vol.18, 2013, issue 3
Stephan vom Dahl, Pramod K. Mistry, Barry E. Rosenbloom, Tamar Taddei
The Link between Psychological Stress and Autoimmune Response in Children
Critical Reviews™ in Immunology, Vol.35, 2015, issue 2
Maria Faresjo
Carbon Source Metabolism and Its Regulation in Cancer Cells
Critical Reviews™ in Eukaryotic Gene Expression, Vol.22, 2012, issue 1
Chengqian Yin, Shuo Qie, Nianli Sang
Role of Treg/Th17 Imbalance, Microbiota and miRNAs in Pancreatic Cancer: Therapeutic Options
Critical Reviews™ in Immunology, Vol.40, 2020, issue 1
Xue Yang, Yi-Ping Mou, Ying-Yu Ma, Jia-Yu Yao, Wei-Wei Jin, Mao-Hua Cai, Luo-Qin Fu