图书馆订阅: Guest
肿瘤形成评论综述™

每年出版 4 

ISSN 打印: 0893-9675

ISSN 在线: 2162-6448

SJR: 0.395 SNIP: 0.322 CiteScore™:: 2.5 H-Index: 54

Indexed in

Defined Tumor Cell-Host Interactions Are Necessary for Malignant Growth

卷 5, 册 1, 1994, pp. 69-105
DOI: 10.1615/CritRevOncog.v5.i1.40
Get accessGet access

摘要

Analyzing the different steps of malignant growth (primary tumor, metastasizing tumor cells, secondary tumor), one recognizes an intense interaction between normal and malignant cells. Tumor cells not only induce activities of normal cells, which normally are rarely activated, but also they exploit properties of normal cells for their own purposes. The major mechanisms and processes of this "parasitism" are described in more detail and the results are discussed. Tumors cannot grow beyond a certain size without a supply of blood and lymph vessels by the host (angiogenesis). Metastasizing tumor cells cannot leave the vessel (extravasate) in which they are transported without the cooperation of the respective endothelial cells of the host. An appropriate environment formed by the host tissues is essential for the settlement of tumor cells at secondary sites. Historically, these are a few examples that show intense cooperation between host and tumor. More are given in the present contribution.

对本文的引用
  1. Bukovsky A., Caudle M.R., Wimalasena J., Keenan J.A., Elder R.F., The role of the host–tumor interface and cell hybridization in invasive cancer, Medical Hypotheses, 57, 6, 2001. Crossref

  2. Arcadi John A., Extracellular matrix in prostate adenocarcinoma:, Urologic Oncology: Seminars and Original Investigations, 3, 4, 1997. Crossref

  3. Saez Enrique, Rutberg Susan E, Mueller Elisabetta, Oppenheim Heather, Smoluk Jennifer, Yuspa Stuart H, Spiegelman Bruce M, c-fos is required for malignant progression of skin tumors, Cell, 82, 5, 1995. Crossref

  4. Bukovsky Antonin, Cekanova Maria, Caudle Michael R., Wimalasena Jay, Foster James S., Keenan Jeffrey A., Elder Robert F., Variability of Placental Expression of Cyclin E Low Molecular Weight Variants1, Biology of Reproduction, 67, 2, 2002. Crossref

  5. Alves F., Vogel W., Ullrich A., Tumorinvasion — die Rolle der Rezeptoren, in Molekularbiologische Grundlagen der Gastroenterologie, 1995. Crossref

  6. Luisetto M, Similarity between Some Biological Systems, Organotropism and Metastatic Process: Active Role Played By Secondary Organ?, Insights in Biology and Medicine, 2018. Crossref

  7. Bouez Charbel, Reynaud Caroline, Noblesse Emmanuelle, Thépot Amélie, Gleyzal Claudine, Kanitakis Jean, Perrier Eric, Damour Odile, Sommer Pascal, The Lysyl Oxidase LOX Is Absent in Basal and Squamous Cell Carcinomas and Its Knockdown Induces an Invading Phenotype in a Skin Equivalent Model, Clinical Cancer Research, 12, 5, 2006. Crossref

  8. Jouanneau J, Moens G, Thiery JP, The community effect in FGF-1 mediated tumor progression of a rat bladder carcinoma does not involve a direct paracrine signaling, Oncogene, 18, 2, 1999. Crossref

Begell Digital Portal Begell 数字图书馆 电子图书 期刊 参考文献及会议录 研究收集 订购及政策 Begell House 联系我们 Language English 中文 Русский Português German French Spain