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肿瘤形成评论综述™
SJR: 0.631 SNIP: 0.503 CiteScore™: 2

ISSN 打印: 0893-9675
ISSN 在线: 2162-6448

肿瘤形成评论综述™

DOI: 10.1615/CritRevOncog.2014010386
pages 77-90

The Pathophysiological Role of Chemokines in the Regulation of NK Cell Tissue Homing

Giovanni Bernardini
Laboratory of Immunology and Immunopathology, Department of Molecular Medicine and Istituto Pasteur-Fondazione Cenci Bolognetti, "Sapienza" Universita di Roma, Rome, Italy
Angela Santoni
Laboratory of Immunology and Immunopathology, Department of Molecular Medicine and Istituto Pasteur-Fondazione Cenci Bolognetti, "Sapienza" Universita di Roma, Rome, Italy

ABSTRACT

Natural killer (NK) cells are an essential component of innate immunity that can rapidly detect and respond to malignant or infected cells. Chemokines play important roles in directing immune responses by controlling tissue homing, retention, and activation of immune cells. Although some chemokines can promote tumor growth and metastasis, others are responsible for extensive infiltration of lymphocytes, thus resulting in a protective anti-tumor immune response. Here, we summarize discoveries that have revealed the role of specific chemokines in regulating the function of NK cells during inflammation, infection, and malignancies.


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