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ISSN 打印: 0893-9675

ISSN 在线: 2162-6448

SJR: 0.395 SNIP: 0.322 CiteScore™:: 2.5 H-Index: 54

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Resistance Mechanisms and Their Regulation in Lung Cancer

卷 7, 册 3-4, 1996, pp. 227-244
DOI: 10.1615/CritRevOncog.v7.i3-4.50
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摘要

Data obtained from multiple sources indicate that no single mechanism can explain the drug resistance and the poor prognosis of patients with lung cancer. The resistance-related proteins P-glycoprotein, glutathione-dependent enzymes, topoisomerase II, metallothioneins, O-6-alkylguanine-DNA alkyltransferase, thymidylate synthase, dihydrofolate reductase and heat shock proteins have been found in lung carcinomas, but these alone cannot explain the drug-resistant phenotype. Cell cycle-related proteins, angiogenic factors, protooncogenes, and tumor suppressor genes also play a role in the phenotype that is resistant lung cancer. A key future challenge involves determining the relative quantitative contributions of each of these mechanisms to overall resistance.

对本文的引用
  1. Theocharis S E, Margeli A P, Klijanienko J T, Kouraklis G P, Metallothionein expression in human neoplasia, Histopathology, 45, 2, 2004. Crossref

  2. Theocharis S, Karkantaris C, Philipides T, Agapitos E, Gika A, Margeli A, Kittas C, Koutselinis A, Expression of metallothionein in lung carcinoma: correlation with histological type and grade, Histopathology, 40, 2, 2002. Crossref

  3. Liu Junhua, Wang Xu, Liu Peng, Deng Rongxin, Lei Min, Chen Wantao, Hu Lihong, 20(S)-Protopanaxadiol (PPD) analogues chemosensitize multidrug-resistant cancer cells to clinical anticancer drugs, Bioorganic & Medicinal Chemistry, 21, 14, 2013. Crossref

  4. Abbas D., Kaloustian J., Orneto C., Piccerelle P., Portugal H., Nicolay A., DSC and physico-chemical properties of a substituted pyridoquinoline and its interaction study with excipients, Journal of Thermal Analysis and Calorimetry, 93, 2, 2008. Crossref

  5. Chen Jianjun, Li Chien-Ming, Wang Jin, Ahn Sunjoo, Wang Zhao, Lu Yan, Dalton James T., Miller Duane D., Li Wei, Synthesis and antiproliferative activity of novel 2-aryl-4-benzoyl-imidazole derivatives targeting tubulin polymerization, Bioorganic & Medicinal Chemistry, 19, 16, 2011. Crossref

  6. Saeed Mohamed, Zeino Maen, Kadioglu Onat, Volm Manfred, Efferth Thomas, Overcoming of P-glycoprotein-mediated multidrug resistance of tumors in vivo by drug combinations, Synergy, 1, 1, 2014. Crossref

  7. Dei Silvia, Budriesi Roberta, Sudwan Paiwan, Ferraroni Marta, Chiarini Alberto, Garnier-Suillerot Arlette, Manetti Dina, Martelli Cecilia, Scapecchi Serena, Teodori Elisabetta, Diphenylcyclohexylamine derivatives as new potent multidrug resistance (MDR) modulators, Bioorganic & Medicinal Chemistry, 13, 4, 2005. Crossref

  8. Volm Manfred, Efferth Thomas, Prediction of Cancer Drug Resistance and Implications for Personalized Medicine, Frontiers in Oncology, 5, 2015. Crossref

  9. Mori Toshiyuki, Okamoto Hiroshi, Takahashi Naoko, Ueda Ryuzo, Okamoto Takashi, Aberrant overexpression of 53BP2 mRNA in lung cancer cell lines, FEBS Letters, 465, 2-3, 2000. Crossref

  10. Teodori E., Dei S., Scapecchi S., Gualtieri F., The medicinal chemistry of multidrug resistance (MDR) reversing drugs, Il Farmaco, 57, 5, 2002. Crossref

  11. Limtrakul P., Khantamat O., Pintha K., Inhibition of P-Glycoprotein Function and Expression by Kaempferol and Quercetin, Journal of Chemotherapy, 17, 1, 2005. Crossref

  12. ZHAO YUAN-YUAN, YU LI, LIU BAO-LING, HE XIN-JIA, ZHANG BI-YUAN, Downregulation of P-gp, Ras and p-ERK1/2 contributes to the arsenic trioxide-induced reduction in drug resistance towards doxorubicin in gastric cancer cell lines, Molecular Medicine Reports, 12, 5, 2015. Crossref

  13. Paul Debasish, Chanukuppa Venkatesh, Reddy Panga Jaipal, Taunk Khushman, Adhav Ragini, Srivastava Sanjeeva, Santra Manas Kumar, Rapole Srikanth, Global proteomic profiling identifies etoposide chemoresistance markers in non-small cell lung carcinoma, Journal of Proteomics, 138, 2016. Crossref

  14. Locke Vicki L., Davey Ross A., Davey Mary W., Modulation of drug and radiation resistance in small cell lung cancer cells by paclitaxel, Anti-Cancer Drugs, 14, 7, 2003. Crossref

  15. Grandjean Fabienne, Brémaud Laure, Verdier Mireille, Robert Jacques, Ratinaud Marie-Hélène, Sequential gene expression of P-glycoprotein (P-gp), multidrug resistance-associated protein (MRP) and lung resistance protein: functional activity of P-gp and MRP present in the doxorubicin-resistant human K562 cell lines, Anti-Cancer Drugs, 12, 3, 2001. Crossref

  16. Volm M, Koomägi R, Mattern J, Efferth T, Protein expression profiles indicative for drug resistance of non-small cell lung cancer, British Journal of Cancer, 87, 3, 2002. Crossref

  17. Tsang Wing-Pui, Chau Sophia P. Y., Fung Kwok-Pui, Kong Siu-Kai, Kwok Tim-Tak, Modulation of multidrug resistance-associated protein 1 (MRP1) by p53 mutant in Saos-2 cells, Cancer Chemotherapy and Pharmacology, 51, 2, 2003. Crossref

  18. Limtrakul Pornngarm, CURCUMIN AS CHEMOSENSITIZER, in The Molecular Targets and Therapeutic Uses of Curcumin in Health and Disease, 595, 2007. Crossref

  19. Efferth Thomas, Saeed Mohamed E.M., Mirghani Elhaj, Alim Awadh, Yassin Zahir, Saeed Elfatih, Khalid Hassan E., Daak Salah, Integration of phytochemicals and phytotherapy into cancer precision medicine, Oncotarget, 8, 30, 2017. Crossref

  20. In Vitro Testing for Drug Sensitivity/Resistance, in Chemotherapy for Gynecological Neoplasms, 2004. Crossref

  21. Martelli Cecilia, Coronnello Marcella, Dei Silvia, Manetti Dina, Orlandi Francesca, Scapecchi Serena, Novella Romanelli Maria, Salerno Milena, Mini Enrico, Teodori Elisabetta, Structure−Activity Relationships Studies in a Series of N,N-Bis(alkanol)amine Aryl Esters as P-Glycoprotein (Pgp) Dependent Multidrug Resistance (MDR) Inhibitors, Journal of Medicinal Chemistry, 53, 4, 2010. Crossref

  22. Teodori Elisabetta, Martelli Cecilia, Salerno Milena, Darghal Nacira, Dei Silvia, Garnier-Suillerot Arlette, Gualtieri Fulvio, Manetti Dina, Scapecchi Serena, Romanelli Maria Novella, Isomeric N,N-Bis(cyclohexanol)amine Aryl Esters:  The Discovery of a New Class of Highly Potent P-Glycoprotein (Pgp)-dependent Multidrug Resistance (MDR) Inhibitors, Journal of Medicinal Chemistry, 50, 4, 2007. Crossref

  23. Martelli Cecilia, Alderighi Daniela, Coronnello Marcella, Dei Silvia, Frosini Maria, Le Bozec Bénédicte, Manetti Dina, Neri Annalisa, Romanelli Maria Novella, Salerno Milena, Scapecchi Serena, Mini Enrico, Sgaragli Giampietro, Teodori Elisabetta, N,N-bis(Cyclohexanol)amine Aryl Esters: A New Class of Highly Potent Transporter-Dependent Multidrug Resistance Inhibitors, Journal of Medicinal Chemistry, 52, 3, 2009. Crossref

  24. Vock Carsten A., Ang Wee Han, Scolaro Claudine, Phillips Andrew D., Lagopoulos Lucienne, Juillerat-Jeanneret Lucienne, Sava Gianni, Scopelliti Rosario, Dyson Paul J., Development of Ruthenium Antitumor Drugs that Overcome Multidrug Resistance Mechanisms, Journal of Medicinal Chemistry, 50, 9, 2007. Crossref

  25. Teodori Elisabetta, Dei Silvia, Garnier-Suillerot Arlette, Gualtieri Fulvio, Manetti Dina, Martelli Cecilia, Romanelli Maria Novella, Scapecchi Serena, Sudwan Paiwan, Salerno Milena, Exploratory Chemistry toward the Identification of a New Class of Multidrug Resistance Reverters Inspired by Pervilleine and Verapamil Models, Journal of Medicinal Chemistry, 48, 23, 2005. Crossref

  26. Quiros-Fernandez I, Molina-Mora JA, Kop-Montero M, Salas-Hidalgo E, Mora-Rodriguez RA, Predicting Cancer Chemosensitivity Based on Intensity/Distribution Profiles of Cells Loaded with a Fluorescent Sphingolipid Analogue, 2018 IEEE International Work Conference on Bioinspired Intelligence (IWOBI), 2018. Crossref

  27. Dong Xiaowei, Mattingly Cynthia A., Tseng Michael T., Cho Moo J., Liu Yang, Adams Val R., Mumper Russell J., Doxorubicin and Paclitaxel-Loaded Lipid-Based Nanoparticles Overcome Multidrug Resistance by Inhibiting P-Glycoprotein and Depleting ATP, Cancer Research, 69, 9, 2009. Crossref

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