图书馆订阅: Guest
肿瘤形成评论综述™

每年出版 4 

ISSN 打印: 0893-9675

ISSN 在线: 2162-6448

SJR: 0.395 SNIP: 0.322 CiteScore™:: 2.5 H-Index: 54

Indexed in

The Role of Transcription Factor YY1 in the Biology of Cancer

卷 22, 册 1-2, 2017, pp. 13-21
DOI: 10.1615/CritRevOncog.2017021071
Get accessGet access

摘要

The transcription factor Yin Yang 1 (YY1) is a ubiquitously expressed protein involved in several biological functions, including embryogenesis, differentiation, replication, and cellular proliferation. YY1 can both activate and repress transcription depending on its interactions with other transcription factors and co-factors. It affects the transcription of a large number of mammalian and viral genes. In this review, we focus on the role of YY1 in cancer biology, including its expression, function, regulation by other upstream factors, and some of its more significant downstream effectors. We also discuss its context-dependent and tumor-specific role in human cancer progression, roles as a prognostic marker, and how its interactions with other cancer-associated factors can be exploited to develop novel targeted therapies.

对本文的引用
  1. Hays Emily, Bonavida Benjamin, YY1 regulates cancer cell immune resistance by modulating PD-L1 expression, Drug Resistance Updates, 43, 2019. Crossref

  2. Wang Qiang, Chen Chen, Ding Qingqing, Zhao Yan, Wang Zhangding, Chen Junjie, Jiang Zerun, Zhang Yan, Xu Guifang, Zhang Jingjing, Zhou Jianwei, Sun Beicheng, Zou Xiaoping, Wang Shouyu, METTL3-mediated m6A modification of HDGF mRNA promotes gastric cancer progression and has prognostic significance, Gut, 69, 7, 2020. Crossref

  3. Bhaskar Rao Divya, Panneerpandian Ponmathi, Balakrishnan Karthik, Ganesan Kumaresan, YY1 regulated transcription‐based stratification of gastric tumors and identification of potential therapeutic candidates, Journal of Cell Communication and Signaling, 15, 2, 2021. Crossref

  4. Michele Gabriele, Giuseppe Testa, Anders Hansen, Molecular mechanisms of YY1 overexpression in human cancers and its prognostic significance, in YY1 in the Control of the Pathogenesis and Drug Resistance of Cancer, 2021. Crossref

  5. Zhang Shuya, Kim Ji Young, Xu Suowen, Liu Huan, Yin Meimei, Koroleva Marina, Guo Jia, Pei Xiuying, Jin Zheng Gen, Endothelial-specific YY1 governs sprouting angiogenesis through directly interacting with RBPJ, Proceedings of the National Academy of Sciences, 117, 9, 2020. Crossref

  6. Zhang Mingran, Xu Yunfeng, Yin Shuai, Qiu Feng, YY1-induced long non-coding RNA PSMA3 antisense RNA 1 functions as a competing endogenous RNA for microRNA 214-5p to expedite the viability and restrict the apoptosis of bladder cancer cells via regulating programmed cell death-ligand 1, Bioengineered, 12, 2, 2021. Crossref

  7. Moens Ugo, Role of Signaling Pathways in the Viral Life Cycle 2.0, International Journal of Molecular Sciences, 23, 14, 2022. Crossref

  8. Yao Weitao, Yan Qiang, Du Xinhui, Hou Jingyu, TNK2‐AS1 upregulated by YY1 boosts the course of osteosarcoma through targeting miR‐4319/WDR1, Cancer Science, 112, 2, 2021. Crossref

  9. Xu Jieyun, Qin Shijie, Yi Yunmeng, Gao Hanyu, Liu Xiaoqi, Ma Fei, Guan Miao, Delving into the Heterogeneity of Different Breast Cancer Subtypes and the Prognostic Models Utilizing scRNA-Seq and Bulk RNA-Seq, International Journal of Molecular Sciences, 23, 17, 2022. Crossref

  10. Bonavida Benjamin, Crosstalks between Yin-Yang 1 (YY1) and autophagy in cancer, in Autophagy in Immune Response: Impact on Cancer Immunotherapy, 2020. Crossref

Begell Digital Portal Begell 数字图书馆 电子图书 期刊 参考文献及会议录 研究收集 订购及政策 Begell House 联系我们 Language English 中文 Русский Português German French Spain