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ISSN 打印: 0893-9675

ISSN 在线: 2162-6448

SJR: 0.395 SNIP: 0.322 CiteScore™:: 2.5 H-Index: 54

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Risk Factors for Esophageal Cancer, with an Emphasis on the Role of Specificity Protein Transcription Factors in Prognosis and Therapy

卷 25, 册 4, 2020, pp. 355-363
DOI: 10.1615/CritRevOncog.2020036449
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摘要

Specificity protein (Sp) transcription factors regulate the expression of genes associated with several cellular processes and play a critical role in early development. Typically, Sp protein expression decreases with age in healthy adults. Research has shown that Sp proteins can impact the development and transformation of cancer cells and other oncogenic processes, including survival, proliferation, spread, and metastasis. Among the Sp proteins, Sp1, Sp3, and Sp4 have been the main targets of study as they are shown to be highly expressed in cancer cells compared to healthy cells. Increased levels of Sp1 are correlated with poor prognosis in some malignancies, including gastrointestinal cancers. In this review, we discuss the role of Sp transcription factors and examine their activities as pro-oncogenic factors in esophageal cancer (EC). Other aspects presented in this review are potential therapeutic options for EC that target Sp1. We summarize the published information on preclinical results using mithramycin and tolfenamic acid.

参考文献
  1. Pennathur A, Gibson MK, Jobe BA, Luketich JD. Oesophageal carcinoma. Lancet. 2013 Feb 2;381(9864):400-12. PubMed PMID: 23374478. Epub 2013/02/05.

  2. Huang FL, Yu SJ. Esophageal cancer: Risk factors, genetic association, and treatment. Asian J Surg. 2018 May;41(3):210-5. PubMed PMID: 27986415. Epub 2016/12/18.

  3. Chen W, Zheng R, Zeng H, Zhang S. The incidence and mortality of major cancers in China, 2012. Chin J Cancer. 2016 Aug 2;35(1):73. PubMed PMID: 27484217. PM-CID: PMC4971631. Epub 2016/08/04.

  4. Wang ZQ, Cai Q, Hu L, He CY, Li JF, Quan ZW, Liu BY, Li C, Zhu ZG. Long noncoding RNA UCA1 induced by SP1 promotes cell proliferation via recruiting EZH2 and activating AKT pathway in gastric cancer. Cell Death Dis. 2017 Jun 1;8(6):e2839. PubMed PMID: 28569779. PM-CID: PMC5520878. Epub 2017/06/02.

  5. McManus DT, Olaru A, Meltzer SJ. Biomarkers of esophageal adenocarcinoma and Barrett's esophagus. Cancer Res. 2004 Mar 1;64(5):1561-9. PubMed PMID: 14996709. Epub 2004/03/05.

  6. Kubo A, Corley DA. Marked multiethnic variation of esophageal and gastric cardia carcinomas within the United States. Am J Gastroenterol. 2004 Apr;99(4):582-8. PubMed PMID: 15089886. Epub 2004/04/20.

  7. El-Serag HB, Mason AC, Petersen N, Key CR. Epidemiological differences between adenocarcinoma of the oesophagus and adenocarcinoma of the gastric cardia in the USA. Gut. 2002 Mar;50(3):368-72. PubMed PMID: 11839716. PMCID: PMC1773122. Epub 2002/02/13.

  8. Cook MB, Chow WH, Devesa SS. Oesophageal cancer incidence in the United States by race, sex, and histologic type, 1977-2005. Br J Cancer. 2009 Sep 1;101(5):855-9. PubMed PMID: 19672254. PMCID: PMC2736840. Epub 2009/08/13.

  9. Chen Z, Ren Y, Du XL, Yang J, Shen Y, Li S, Wu Y, Lv M, Dong D, Li E, Li W, Liu P, Yang J, Yi M. Incidence and survival differences in esophageal cancer among 18. ethnic groups in the United States. Oncotarget. 2017 Jul 18;8(29):47037-51. PubMed PMID: 28410201. PMCID: PMC5564542. Epub 2017/04/15.

  10. Cook MB, Wild CP, Forman D. A systematic review and meta-analysis of the sex ratio for Barrett's esophagus, erosive reflux disease, and nonerosive reflux disease. 19. Am J Epidemiol. 2005 Dec 1;162(11):1050-61. PubMed PMID: 16221805. Epub 2005/10/14.

  11. Kubo A, Corley DA. Marked regional variation in adenocarcinomas of the esophagus and the gastric cardia in the United States. Cancer. 2002 Nov 15;95(10):2096-102. 20. PubMed PMID: 12412162. Epub 2002/11/02.

  12. Cook MB, Kamangar F, Whiteman DC, Freedman ND, Gammon MD, Bernstein L, Brown LM, Risch HA, Ye W, Sharp L, Pandeya N, Webb PM, Wu AH, Ward MH, Giffen C, Casson AG, Abnet CC, Murray LJ, Corley DA, 21. Nyren O, Vaughan TL, Chow WH. Cigarette smoking and adenocarcinomas of the esophagus and esophago-gastric junction: A pooled analysis from the international BEACON consortium. J Natl Cancer Inst. 2010 Sep 22. 8;102(17):1344-53. PubMed PMID: 20716718. PMCID: PMC2935475. Epub 2010/08/19.

  13. Pandeya N, Williams G, Green AC, Webb PM, Whiteman DC, Australian Cancer Study. Alcohol consumption and the risks of adenocarcinoma and squamous cell carcinoma of the esophagus. Gastroenterology. 2009 23. Apr;136(4):1215-24, e1-2. PubMed PMID: 19250648. Epub 2009/03/03.

  14. Cook MB, Corley DA, Murray LJ, Liao LM, Kamangar 24. F, Ye W, Gammon MD, Risch HA, Casson AG, Freedman ND, Chow WH, Wu AH, Bernstein L, Nyren O, Pandeya N, Whiteman DC, Vaughan TL. Gastroesophageal reflux in relation to adenocarcinomas of the esophagus: 25. A pooled analysis from the Barrett's and Esophageal Adenocarcinoma Consortium (BEACON). PLoS One. 2014;9(7):e103508. PubMed PMID: 25075959. PMCID: 26. PMC4116205. Epub 2014/07/31.

  15. Corley DA, Kubo A, Zhao W. Abdominal obesity and the risk of esophageal and gastric cardia carcinomas. Cancer Epidemiol Biomarkers Prev. 2008 Feb;17(2):352-8. PubMed PMID: 18268119. PMCID: PMC2670999. Epub 27. 2008/02/13.

  16. Watanabe M, Otake R, Kozuki R, Toihata T, Takahashi K, Okamura A, Imamura Y. Recent progress in multi-disciplinary treatment for patients with esophageal cancer. Surg Today. 2020 Jan;50(1):12-20. PubMed PMID: 31535225. PMCID: PMC6952324. Epub 2019/09/20.

  17. Kato K, Nakajima TE, Ito Y, Katada C, Ishiyama H, Tokunaga SY, Tanaka M, Hironaka S, Hashimoto T, Ura T, Kodaira T, Yoshimura K. Phase II study of concurrent chemoradiotherapy at the dose of 50.4 Gy with elective nodal irradiation for Stage II-III esophageal carcinoma. Jpn J Clin Oncol. 2013 Jun;43(6):608-15. PubMed PMID: 23585687. Epub 2013/04/16.

  18. Dong H, Strome SE, Salomao DR, Tamura H, Hirano F, Flies DB, Roche PC, Lu J, Zhu G, Tamada K, Lennon VA, Celis E, Chen L. Tumor-associated B7-H1 promotes T-cell apoptosis: A potential mechanism of immune evasion. Nat Med. 2002 Aug;8(8):793-800. PubMed PMID: 12091876. Epub 2002/07/02.

  19. Safe S, Abbruzzese J, Abdelrahim M, Hedrick E. Specificity protein transcription factors and cancer: Opportunities for drug development. Cancer Prev Res (Phila). 2018 Jul;11(7):371-82. PubMed PMID: 29545399. Epub 2018/03/17.

  20. Pathi S, Jutooru I, Chadalapaka G, Nair V, Lee SO, Safe S. Aspirin inhibits colon cancer cell and tumor growth and downregulates specificity protein (Sp) transcription factors. PLoS One. 2012;7(10):e48208. PubMed PMID: 23110215. PMCID: PMC3482208. Epub 2012/10/31.

  21. Vizcaino C, Mansilla S, Portugal J. Sp1 transcription factor: A long-standing target in cancer chemotherapy. Pharmacol Ther. 2015 Aug;152:111-24. PubMed PMID: 25960131. Epub 2015/05/12.

  22. Gupta SC, Kim JH, Prasad S, Aggarwal BB. Regulation of survival, proliferation, invasion, angiogenesis, and metastasis of tumor cells through modulation of inflammatory pathways by nutraceuticals. Cancer Metastasis Rev. 2010 Sep;29(3):405-34. PubMed PMID: 20737283. PMCID: PMC2996866. Epub 2010/08/26.

  23. Hanahan D, Weinberg RA. Hallmarks of cancer: The next generation. Cell. 2011 Mar 4;144(5):646-74. PubMed PMID: 21376230. Epub 2011/03/08.

  24. Suske G, Bruford E, Philipsen S. Mammalian SP/KLF transcription factors: Bring in the family. Genomics. 2005 May;85(5):551-6. PubMed PMID: 15820306. Epub 2005/04/12.

  25. Beishline K, Azizkhan-Clifford J. Sp1 and the "hallmarks of cancer." FEBS J. 2015 Jan;282(2):224-58. PubMed PMID: 25393971. Epub 2014/11/14.

  26. Higgins KJ, Abdelrahim M, Liu S, Yoon K, Safe S. Regulation of vascular endothelial growth factor receptor-2 expression in pancreatic cancer cells by Sp proteins. Biochem Biophys Res Commun. 2006 Jun 23;345(1):292-301. PubMed PMID: 16678129. Epub 2006/05/09.

  27. Li L, Davie JR. The role of Sp1 and Sp3 in normal and cancer cell biology. Ann Anat. 2010 Sep 20;192(5):275-83. PubMed PMID: 20810260. Epub 2010/09/03.

  28. Oleaga C, Welten S, Belloc A, Sole A, Rodriguez L, Mencia N, Selga E, Tapias A, Noe V, Ciudad CJ. Identification of novel Sp1 targets involved in proliferation and cancer by functional genomics. Biochem Pharmacol. 2012 Dec 15;84(12):1581-91. PubMed PMID: 23018034. Epub 2012/09/29.

  29. Thiesen HJ, Bach C. Target detection assay (TDA): A versatile procedure to determine DNA binding sites as demonstrated on SP1 protein. Nucleic Acids Res. 1990 Jun 11;18(11):3203-9. PubMed PMID: 2192357. PM-CID: PMC330924. Epub 1990/06/11.

  30. Marin M, Karis A, Visser P, Grosveld F, Philipsen S. Transcription factor Sp1 is essential for early embryonic development but dispensable for cell growth and differentiation. Cell. 1997 May 16;89(4):619-28. PubMed PMID: 9160753. Epub 1997/05/16.

  31. Ammanamanchi S, Freeman JW, Brattain MG. Acetylated SP3 is a transcriptional activator. J Biol Chem. 2003 Sep 12;278(37):35775-80. PubMed PMID: 12837748. Epub 2003/07/03.

  32. He S, Sun JM, Li L, Davie JR. Differential intranuclear organization of transcription factors Sp1 and Sp3. Mol Biol Cell. 2005 Sep;16(9):4073-83. PubMed PMID: 15987735. PMCID: PMC1196320. Epub 2005/07/01.

  33. Koutsodontis G, Vasilaki E, Chou WC, Papakosta P, Kardassis D. Physical and functional interactions between members of the tumour suppressor p53 and the Sp families of transcription factors: Importance for the regulation of genes involved in cell-cycle arrest and apoptosis. Biochem J. 2005 Jul 15;389(Pt 2):443-55. PubMed PMID: 15790310. PMCID: PMC1175122. Epub 2005/03/26.

  34. Macleod D, Charlton J, Mullins J, Bird AP. Sp1 sites in the mouse APRT gene promoter are required to prevent methylation of the CpG island. Genes Dev. 1994 Oct 1;8(19):2282-92. PubMed PMID: 7958895. Epub 1994/10/01.

  35. O'Connor L, Gilmour J, Bonifer C. The role of the ubiquitously expressed transcription factor Sp1 in tissue-specific transcriptional regulation and in disease. Yale J Biol Med. 2016 Dec;89(4):513-25. PubMed PMID: 28018142. PM-CID: PMC5168829. Epub 2016/12/27.

  36. Saffer JD, Jackson SP, Annarella MB. Developmental expression of Sp1 in the mouse. Mol Cell Biol. 1991 Apr;11(4):2189-99. PubMed PMID: 2005904. PMCID: PMC359911. Epub 1991/04/01.

  37. Gu L, Sang M, Li J, Liu F, Wu Y, Liu S, Wang P, Shan B. Expression and prognostic significance of MAGE-A11 and transcription factors (Sp1, TFCP2, and ZEB1) in ESCC tissues. Pathol Res Pract. 2019 Jul;215(7):152446. PubMed PMID: 31126819. Epub 2019/05/28.

  38. Mei LL, Wang WJ, Qiu YT, Xie XF, Bai J, Shi ZZ. miR-145-5p suppresses tumor cell migration, invasion and epithelial to mesenchymal transition by regulating the Sp1/NF-kappaB signaling pathway in esophageal squamous cell carcinoma. Int J Mol Sci. 2017 Aug 23;18(9). PubMed PMID: 28832500. PMCID: PMC5618482. Epub 2017/08/24.

  39. Papineni S, Chintharlapalli S, Abdelrahim M, Lee SO, Burghardt R, Abudayyeh A, Baker C, Herrera L, Safe S. Tolfenamic acid inhibits esophageal cancer through repression of specificity proteins and c-Met. Carcinogenesis. 2009 Jul;30(7):1193-201. PubMed PMID: 19406933. PMCID: PMC2704282. Epub 2009/05/02.

  40. Jiang D, He Z, Wang C, Zhou Y, Li F, Pu W, Zhang X, Feng X, Zhang M, Yecheng X, Xu Y, Jin L, Guo S, Wang J, Wang M. Epigenetic silencing of ZNF132 mediated by methylation-sensitive Sp1 binding promotes cancer progression in esophageal squamous cell carcinoma. Cell Death Dis. 2018 Dec 18;10(1):1. PubMed PMID: 30578410. PMCID: PMC6315024. Epub 2018/12/24.

  41. Cao HH, Zheng CP, Wang SH, Wu JY, Shen JH, Xu XE, Fu JH, Wu ZY, Li EM, Xu LY. A molecular prognostic model predicts esophageal squamous cell carcinoma prognosis. PLoS One. 2014;9(8):e106007. PubMed PMID: 25153136. PMCID: PMC4143329. Epub 2014/08/26.

  42. Xu H, Jiang J, Zhang J, Cheng L, Pan S, Li Y. Mi-croRNA-375 inhibits esophageal squamous cell carcinoma proliferation through direct targeting of Sp1. Exp Ther Med. 2019 Mar;17(3):1509-16. PubMed PMID: 30867685. PMCID: PMC6396021. Epub 2019/03/15.

  43. Zhang M, Mathur A, Zhang Y, Xi S, Atay S, Hong JA, Datrice N, Upham T, Kemp CD, Ripley RT, Wiegand G, Avital I, Fetsch P, Mani H, Zlott D, Robey R, Bates SE, Li X, Rao M, Schrump DS. Mithramycin represses basal and cigarette smoke-induced expression of ABCG2 and inhibits stem cell signaling in lung and esophageal cancer cells. Cancer Res. 2012 Aug 15;72(16):4178-92. PubMed PMID: 22751465. PMCID: PMC6261440. Epub 2012/07/04.

  44. Ludwig JA, Weinstein JN. Biomarkers in cancer staging, prognosis and treatment selection. Nat Rev Cancer. 2005 Nov;5(11):845-56. PubMed PMID: 16239904. Epub 2005/10/22.

  45. Maliakal P, Abdelrahim M, Sankpal UT, Maliakal C, Baker CH, Safe S, Herrera LJ, Abudayyeh A, Kaja S, Basha R. Chemopreventive effects of tolfenamic acid against esophageal tumorigenesis in rats. Invest New Drugs. 2012 Jun;30(3):853-61. PubMed PMID: 21197621. Epub 2011/01/05.

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