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肿瘤形成评论综述™
SJR: 0.631 SNIP: 0.503 CiteScore™: 2

ISSN 打印: 0893-9675
ISSN 在线: 2162-6448

肿瘤形成评论综述™

DOI: 10.1615/CritRevOncog.2018027689
pages 235-245

Surveillance of HPV-Positive Head and Neck Squamous Cell Carcinoma with Circulating and Salivary DNA Biomarkers

Daniele Borsetto
School of Cancer Sciences, Institute of Head and Neck Studies and Education, University of Birmingham, Birmingham, United Kingdom
Jordan Cheng
School of Dentistry, University of California Los Angeles, Los Angeles, California, United States of America
Karl Payne
School of Cancer Sciences, Institute of Head and Neck Studies and Education, University of Birmingham, Birmingham, United Kingdom
Paul Nankivell
School of Cancer Sciences, Institute of Head and Neck Studies and Education, University of Birmingham, Birmingham, United Kingdom
Nikolas Batis
School of Cancer Sciences, Institute of Head and Neck Studies and Education, University of Birmingham, Birmingham, United Kingdom
Kanishka Rao
School of Cancer Sciences, Institute of Head and Neck Studies and Education, University of Birmingham, Birmingham, United Kingdom
Shreerang Bhide
The Royal Marsden Hospital and The Institute of Cancer Research, Sutton and London, United Kingdom
Feng Li
School of Dentistry, University of California Los Angeles, Los Angeles, California, United States of America
Yong Kim
School of Dentistry, University of California Los Angeles, Los Angeles, California, United States of America
Hisham Mehanna
School of Cancer Sciences, Institute of Head and Neck Studies and Education, University of Birmingham, Birmingham, United Kingdom
David Wong
School of Dentistry, University of California Los Angeles, Los Angeles, California, United States of America

ABSTRACT

Head and neck squamous cell carcinoma (HNSCC) manifests in the mucosal epithelial lining of the oral cavity, oropharynx, hypopharynx, nasopharynx or larynx and has a tremendous disease burden worldwide. Smoking and alcohol consumption were once major risk factors, but HPV-associated infection has emerged as the major contributor to HNSCC occurrence in developed countries. Circulating biomarker evaluations in biofluids, also known as liquid biopsy, are an attractive alternative for cancer screening as they are minimally invasive, potentially low cost, and easily repeatable on a serial basis. This review summarizes the current knowledge and potential of assessing circulating blood and salivary HPV DNA and HPV antibodies for the surveillance of HPV-positive HNSCC. Additionally, the biological underpinnings of the presence and relevance of circulating HPV DNA is discussed.