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ISSN 打印: 0893-9675

ISSN 在线: 2162-6448

SJR: 0.395 SNIP: 0.322 CiteScore™:: 2.5 H-Index: 54

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The Nature of Reed-Sternberg Cells: Phenotype, Genotype, and Other Properties

卷 5, 册 2-3, 1994, pp. 213-245
DOI: 10.1615/CritRevOncog.v5.i2-3.60
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Su-Ming Hsu
Department of Pathology, University of Arkansas for Medical Sciences, Arkansas Cancer Research Center, and John L. McClellan Veterans Memorial Hospital, Little Rock, Arkansas
Pei-Ling Hsu
Department of Pathology, University of Arkansas for Medical Sciences, Arkansas Cancer Research Center, and John L. McClellan Veterans Memorial Hospital, Little Rock, Arkansas

摘要

The most recent sophisticated investigations have provided new and revealing but also contradictory and controversial information on the biological nature and the cellular origin of Hodgkin and Reed-Sternberg (H-RS) cells. Immunophenotypic analyses have shown consistent expression of CD 15, CD30, CD74, and HLA-Dr antigens, but generally lack of T- or B cell-associated markers in H-RS cells. The H-RS cells are also devoid of many monocyte/macrophage-associated antigens. Molecular genetic studies have demonstrated heterogeneous findings with respect to rearrangements of T-cell receptor and immunoglobulin genes. Only a small percentage of the cases have rearrangements; this cannot always be attributed to the threshold of sensitivity of the method and/ or the scarcity of the malignant cells in tissues examined. The H-RS cells do not express transcription factors such as BSAP, TCF-1, and GATA-3, known to be associated with lymphoid cells. It appears that evidence to support a lymphoid origin for H-RS cells is still lacking. On the contrary, the mechanism responsible for the unique clinical and histopathologic alterations associated with this disease has become clear. The H-RS cells have been shown to secrete IL-1, IL-5, IL-6, IL-9, TNF-a, M-CSF, and TGF-b, and, less frequently, IL-4 and G-CSF. These cytokines are likely to be responsible for the increased cellular reaction and fibrosis observed in tissues involved by HD and for the immunosuppression in patients with HD. Like most lymphomas, the etiology or pathogenesis of HD remains unknown. The Epstein-Barr virus (EBV) genomes are clonally integrated in the H-RS cells of about half the cases. The significance of these findings, whether EBV is a causative agent or an epiphenomenon, remains to be elucidated.

键词: Hodgkin's disease, cytokine, oncogenes, review
对本文的引用

  1. Hsu Su-Ming, Waldron James, Xie Su-Su, Hsu Pei-Ling, Hodgkin's disease and anaplastic large cell lymphoma revisited, Journal of Biomedical Science, 3, 1, 1996. Crossref

  2. AL SAATI TALAL, GALOIN SANDRINE, GRAVEL SYLVIA, LAMANT LAURENCE, RODA DANIEL, CHITTAL SHASHIKANT M., DELSOL GEORGES, IgH AND TcR-γ GENE REARRANGEMENTS IDENTIFIED IN HODGKIN'S DISEASE BY PCR DEMONSTRATE LACK OF CORRELATION BETWEEN GENOTYPE, PHENOTYPE, AND EPSTEIN-BARRVIRUS STATUS, The Journal of Pathology, 181, 4, 1997. Crossref

  3. van Vuren Annelies, Meyer-Wentrup Friederike, New targets for antibody therapy of pediatric B cell lymphomas, Pediatric Blood & Cancer, 61, 12, 2014. Crossref

  4. Moss Denis J., Schmidt Christopher, Elliott Suzanne, Suhrbier Andreas, Burrows Scott, Khanna Rajiv, , 69, 1996. Crossref

  5. Diepstra A., Niens M., Te Meerman G. J., Poppema S., Berg A., Genetic susceptibility to Hodgkin's lymphoma associated with the human leukocyte antigen region, European Journal of Haematology, 75, 2005. Crossref

  6. Horie Ryouichi, Higashihara Masaaki, Watanabe Toshiki, Hodgkin’s Lymphoma and CD30 Signal Transduction, International Journal of Hematology, 77, 1, 2003. Crossref

  7. Hsu Pei-Ling, Hsu Su-Ming, Autocrine Growth Regulation of CD30 Ligand in CD30-Expressing Reed-Sternberg Cells: Distinction Between Hodgkin's Disease and Anaplastic Large Cell Lymphoma, Laboratory Investigation, 80, 7, 2000. Crossref

  8. Holden R.J., Pakula I.S., The role of tumor necrosis factor-α in the pathogenesis of anorexia and bulimia nervosa, cancer cachexia and obesity, Medical Hypotheses, 47, 6, 1996. Crossref

  9. Pötter R, Paediatric Hodgkin's disease, European Journal of Cancer, 35, 10, 1999. Crossref

  10. Gruss Hans-Jürgen, Kadin Marshall E., 2 Pathophysiology of Hodgkin's disease: functional and molecular aspects, Baillière's Clinical Haematology, 9, 3, 1996. Crossref

  11. Croager Emma J., Gout Alexander M., Abraham Lawrence J., Involvement of Sp1 and Microsatellite Repressor Sequences in the Transcriptional Control of the Human CD30 Gene, The American Journal of Pathology, 156, 5, 2000. Crossref

  12. Chu Peiguo G., Chang Karen L., Arber Daniel A., Weiss Lawrence M., Practical applications of immunohistochemistry in hematolymphoid neoplasms, Annals of Diagnostic Pathology, 3, 2, 1999. Crossref

  13. Xiao Qianxun, Shen Ning, Hedvat Cyrus V., Moskowitz Craig H., Sussman Louis K., Filippa Daniel A., Zelenetz Andrew D., Houldsworth Jane, Chaganti Raju S. K., Teruya-Feldstein Julie, Differential Expression Patterns of c-REL Protein in Classic and Nodular Lymphocyte Predominant Hodgkin Lymphoma, Applied Immunohistochemistry & Molecular Morphology, 12, 3, 2004. Crossref

  14. Ayoub Jean-Pierre, Palmer Judy Lynn, Huh Yang, Cabanillas Fernando, Younes Anas, Therapeutic and Prognostic Implications of Peripheral Blood Lymphopenia in Patients with Hodgkin's Disease, Leukemia & Lymphoma, 34, 5-6, 1999. Crossref

  15. Hinz Michael , Lemke Petra , Anagnostopoulos Ioannis , Hacker Christine , Krappmann Daniel , Mathas Stephan , Dörken Bernd , Zenke Martin , Stein Harald , Scheidereit Claus , Nuclear Factor κB–dependent Gene Expression Profiling of Hodgkin's Disease Tumor Cells, Pathogenetic Significance, and Link to Constitutive Signal Transducer and Activator of Transcription 5a Activity , Journal of Experimental Medicine, 196, 5, 2002. Crossref

  16. Cabot Richard C., Scully Robert E., Mark Eugene J., McNeely William F., Shepard Jo-Anne O., Ebeling Sally H., Ellender Stacey M., Peters Christine C., Nutman Thomas B., Kradin Richard L., Case 1-2002, New England Journal of Medicine, 346, 2, 2002. Crossref

  17. Clodi Katharina, Asgari Zahra, Younes Mamoun, Palmer J. Lynn, Cabanillas Fernando, Carbone Antonino, Andreeff Michael, Younes Anas, Expression of CD40 ligand (CD154) in B and T lymphocytes of Hodgkin disease, Cancer, 94, 1, 2002. Crossref

  18. Izban Keith F, Ergin Melek, Huang Qin, Qin Jian-zhong, Martinez Robert L, Schnitzer Bertram, Ni Hongyu, Nickoloff Brian J, Alkan Serhan, Characterization of NF-κB Expression in Hodgkin’s Disease: Inhibition of Constitutively Expressed NF-κB Results in Spontaneous Caspase-Independent Apoptosis in Hodgkin and Reed-Sternberg Cells, Modern Pathology, 14, 4, 2001. Crossref

  19. Izban Keith F, Ergin Melek, Martinez Robert L, Alkan Serhan, Expression of the Tumor Necrosis Factor Receptor-Associated Factors (TRAFs) 1 and 2 is a Characteristic Feature of Hodgkin and Reed-Sternberg Cells, Modern Pathology, 13, 12, 2000. Crossref

  20. Ravoet Christophe, DeMartin Sonia, Gerard Raymonde, Dehon Michel, Peny Marie-Odile, Petit Bénédicte, Delannoy André, Husson Bernard, Contribution of Flow Cytometry to the Diagnosis of Malignant and Non Malignant Conditions in Lymph Node Biopsies, Leukemia & Lymphoma, 45, 8, 2004. Crossref

  21. Krenacs Laszlo, Himmelmann Andreas W., Quintanilla-Martinez Leticia, Fest Thierry, Riva Agostino, Wellmann Axel, Bagdi Eniko, Kehrl John H., Jaffe Elaine S., Raffeld Mark, Transcription Factor B-Cell–Specific Activator Protein (BSAP) Is Differentially Expressed in B Cells and in Subsets of B-Cell Lymphomas, Blood, 92, 4, 1998. Crossref

  22. Krenacs Laszlo, Himmelmann Andreas W., Quintanilla-Martinez Leticia, Fest Thierry, Riva Agostino, Wellmann Axel, Bagdi Eniko, Kehrl John H., Jaffe Elaine S., Raffeld Mark, Transcription Factor B-Cell–Specific Activator Protein (BSAP) Is Differentially Expressed in B Cells and in Subsets of B-Cell Lymphomas, Blood, 92, 4, 1998. Crossref

  23. Lee Im-soon, Kim Min Kyung, Choi Eun Young, Mehl Anja, Jung Kyeong Cheon, Gil Min Chan, Rowe Martin, Park Seong Hoe, CD99 expression is positively regulated by Sp1 and is negatively regulated by Epstein-Barr virus latent membrane protein 1 through nuclear factor-κB, Blood, 97, 11, 2001. Crossref

  24. Hinz Michael, Löser Peter, Mathas Stephan, Krappmann Daniel, Dörken Bernd, Scheidereit Claus, Constitutive NF-κB maintains high expression of a characteristic gene network, including CD40, CD86, and a set of antiapoptotic genes in Hodgkin/Reed-Sternberg cells, Blood, 97, 9, 2001. Crossref

  25. Ohshima Koichi, Sugihara Midori, Suzumiya Junji, Haraoka Seiji, Kanda Motonobu, Shimazaki Kae, Katoh Kei, Kumagawa Midori, Kikuchi Masahiro, Basic Fibroblast Growth Factor and Fibrosis in Hodgkin's Disease, Pathology - Research and Practice, 195, 3, 1999. Crossref

  26. Opinto Giuseppina, Agostinelli Claudio, Ciavarella Sabino, Guarini Attilio, Maiorano Eugenio, Ingravallo Giuseppe, Hodgkin Lymphoma: A Special Microenvironment, Journal of Clinical Medicine, 10, 20, 2021. Crossref

  27. Krappmann Daniel, Emmerich Florian, Kordes Uwe, Scharschmidt Erika, Dörken Bernd, Scheidereit Claus, Molecular mechanisms of constitutive NF-κB/Rel activation in Hodgkin/Reed-Sternberg cells, Oncogene, 18, 4, 1999. Crossref

  28. Steidl Christian, Connors Joseph M., Gascoyne Randy D., Molecular Pathogenesis of Hodgkin's Lymphoma: Increasing Evidence of the Importance of the Microenvironment, Journal of Clinical Oncology, 29, 14, 2011. Crossref

  29. Diepstra Arjan, van Imhoff Gustaaf W., Karim-Kos Henrike E., van den Berg Anke, te Meerman Gerard J., Niens Marijke, Nolte Ilja M., Bastiaannet Esther, Schaapveld Michael, Vellenga Edo, Poppema Sibrand, HLA Class II Expression by Hodgkin Reed-Sternberg Cells Is an Independent Prognostic Factor in Classical Hodgkin's Lymphoma, Journal of Clinical Oncology, 25, 21, 2007. Crossref

  30. Su Che-Chun, Chiu Hsiu-Hui, Chang Chia-Che, Chen Jui-Chieh, Hsu Su-Ming, CD30 Is Involved in Inhibition of T-Cell Proliferation by Hodgkin’s Reed-Sternberg Cells, Cancer Research, 64, 6, 2004. Crossref

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