图书馆订阅: Guest
Begell Digital Portal Begell 数字图书馆 电子图书 期刊 参考文献及会议录 研究收集
肿瘤形成评论综述™
SJR: 0.631 SNIP: 0.503 CiteScore™: 2.2

ISSN 打印: 0893-9675
ISSN 在线: 2162-6448

肿瘤形成评论综述™

DOI: 10.1615/CritRevOncog.2013010596
pages 559-571

Aging, Nutrient Signaling, Hematopoietic Senescence, and Cancer

Priya Balasubramanian
Andrus Gerontology Center, University of Southern California, 3715 McClintock Avenue, Los Angeles, California 90089-0191, USA
Valter D. Longo
Andrus Gerontology Center, the Molecular and Computational Biology Department, and the Norris Cancer Center, University of Southern California, 3715 McClintock Avenue, Los Angeles, California 90089-0191, USA

ABSTRACT

It is well known that cancer is one of the main causes of mortality in the aged population. Recent studies suggest that oncogenic pathways, such as the insulin-like growth factor-1 (IGF-I), Ras, and Akt/PKB, can contribute to both aging and cancer not only by promoting growth and preventing apoptosis, but also by promoting DNA damage and genomic instability. Epidemiological studies suggest that the chronic, low-grade inflammation that accompanies aging also contributes to tissue damage and tumor progression. Coupled with the accumulation of senescent cells and declining immune function, this leads to the generation and survival of cancer cells, possibly explaining why advanced age is the primary risk factor for cancer.


Articles with similar content:

Toll-like Receptor Modulation in Head and Neck Cancer
Critical Reviews™ in Immunology, Vol.28, 2008, issue 3
Barbara Wollenberg, Sandra Wulff, Ralph Pries
Mechanisms That Contribute to the Development of Lymphoid Malignancies: Roles for Genetic Alterations and Cytokine Production
Critical Reviews™ in Immunology, Vol.16, 1996, issue 1
Kenneth L. Bost, Laura S. Levy
The Immune System in the Pathogenesis of Ovarian Cancer
Critical Reviews™ in Immunology, Vol.33, 2013, issue 2
Ellen L. Goode, Kimberly R. Kalli, Keith L. Knutson, Melissa S. DeRycke, Bridget Charbonneau
Effect of Circadian Rhythm on Clinical and Pathophysiological Conditions and Inflammation
Critical Reviews™ in Immunology, Vol.35, 2015, issue 4
Shogo Sato, Takako Kizaki, Hideki Ohno, Tetsuya Izawa, Kenji Suzuki, Yoshinobu Ohira, Takuya Sakurai, Junetsu Ogasawara, Ken Shirato
The Pathophysiological Role of Chemokines in the Regulation of NK Cell Tissue Homing
Critical Reviews™ in Oncogenesis, Vol.19, 2014, issue 1-2
Giovanni Bernardini, Angela Santoni