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肿瘤形成评论综述™
SJR: 0.631 SNIP: 0.503 CiteScore™: 2.2

ISSN 打印: 0893-9675
ISSN 在线: 2162-6448

肿瘤形成评论综述™

DOI: 10.1615/CritRevOncog.v17.i4.30
pages 331-343

Current Status of Radiation Therapy for the Management of Rectal Cancer

William Rule
Department of Radiation Oncology, Mayo Clinic-Arizona, Phoenix, AZ
Jeffrey Meyer
Department of Radiation Oncology, University of Texas Southwestern, Dallas, TX

ABSTRACT

Neoadjuvant chemoradiation for stage II and III rectal adenocarcinoma patients is delivered on a routine basis. This treatment paradigm, built on decades of clinical study, is continuously evolving. While multiple radiosensitizers have gained a great deal of interest over the past couple of decades, 5-fluorouracil still remains as the standard radiosensitizing agent. Long-course preoperative chemoradiotherapy is the current standard of care in the Unites States, but short-course hypofractionated preoperative radiotherapy is advocated by some investigators. This review will discuss the current standard of care in the preoperative setting for patients with rectal cancer and will also examine the novel ways in which investigators are modifying this regimen in an effort to improve patient outcomes.


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