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ISSN 打印: 1064-2285
ISSN 在线: 2162-6561

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DOI: 10.1615/HeatTransRes.2012006187
pages 245-272

BIOPRESERVATION: HEAT/MASS TRANSFER CHALLENGES AND BIOCHEMICAL/GENETIC ADAPTATIONS IN BIOLOGICAL SYSTEMS

Ram V. Devireddy
Department of Mechanical Engineering, Louisiana State University, Baton Rouge, LA 70803

ABSTRACT

Biopreservation is the science of extending the shelf life (storage time) of biological systems. The scientific field of biopreservation can be broadly classified into three distinct but interrelated research areas: Cryopreservation (storage by freezing), Desiccation (storage by drying) and Freeze‐Drying (storage by first freezing and then sublimating the frozen water). Although, both freeze‐drying and desiccation create products that are easier to store and transport, they have not, as yet, been successfully applied to store a variety of biological specimens. However, both these technologies have been quite successfully applied in a variety of fields including pharmaceutical sciences and food industry, as demonstrated by the easy availability of shelf‐stable drugs and instant mashed potatoes! On the other hand, freezing storage has a long and storied history of being used to transport biological specimens, over long distances, as far back as the time of the Pharaohs. However, the lack of portable refrigeration/freezing techniques (and the inviolate second law) limited the use of cryopreservation in every‐day life, until the early 19th century. This short review will outline some of the challenges and opportunities in the fields of engineering, heat and mass transfer, biochemical and genetic adaptations in the preservation of biological systems.


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