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生物医学工程评论综述™
SJR: 0.207 SNIP: 0.376 CiteScore™: 0.79

ISSN 打印: 0278-940X
ISSN 在线: 1943-619X

生物医学工程评论综述™

DOI: 10.1615/CritRevBiomedEng.v37.i4-5.10
pages 283-320

Molecular Aspects of Cardiac Differentiation in Embryonic Stem Cells

Prasenjit Sarkar
Department of Chemical and Biomolecular Engineering, North Carolina State University, Raleigh, North Carolina, USA
Balaji M. Rao
Department of Chemical and Biomolecular Engineering, North Carolina State University, USA

ABSTRACT

Embryonic stem cells (ESCs) are culture-adapted pluripotent cells derived from the inner cell mass of the blastocyst-stage embryo. ESCs provide unique opportunities to study the molecular basis of the process of differentiation that gives rise to all the somatic cell types of the body, including cells of the cardiac lineages. Many protocols have been established to obtain cells of the cardiac lineage from ESCs in vitro. More recently, a clearer picture of the regulatory networks governing cardiac differentiation has begun to emerge. Herein, we summarize the current methods to obtain cells of the cardiac lineages from ESCs and present a review of the signaling pathways, transcription factors, and target genes involved in cardiac differentiation.