每年出版 6 期
ISSN 打印: 0278-940X
ISSN 在线: 1943-619X
Indexed in
Sepsis: From Pattern to Mechanism and Back
摘要
Sepsis is a clinical entity in which complex inflammatory and physiological processes are mobilized, not only across a range of cellular and molecular interactions, but also in clinically relevant physiological signals accessible at the bedside. There is a need for a mechanistic understanding that links the clinical phenomenon of physiologic variability with the underlying patterns of the biology of inflammation, and we assert that this can be facilitated through the use of dynamic mathematical and computational modeling. An iterative approach of laboratory experimentation and mathematical/computational modeling has the potential to integrate cellular biology, physiology, control theory, and systems engineering across biological scales, yielding insights into the control structures that govern mechanisms by which phenomena, detected as biological patterns, are produced. This approach can represent hypotheses in the formal language of mathematics and computation, and link behaviors that cross scales and domains, thereby offering the opportunity to better explain, diagnose, and intervene in the care of the septic patient.
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Zaaqoq Akram M., Namas Rami, Almahmoud Khalid, Azhar Nabil, Mi Qi, Zamora Ruben, Brienza David M., Billiar Timothy R., Vodovotz Yoram, Inducible Protein-10, a Potential Driver of Neurally Controlled Interleukin-10 and Morbidity in Human Blunt Trauma*, Critical Care Medicine, 42, 6, 2014. Crossref
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Namas Rami A., Mi Qi, Namas Rajaie, Almahmoud Khalid, Zaaqoq Akram M., Abdul-Malak Othman, Azhar Nabil, Day Judy, Abboud Andrew, Zamora Ruben, Billiar Timothy R., Vodovotz Yoram, Insights into the Role of Chemokines, Damage-Associated Molecular Patterns, and Lymphocyte-Derived Mediators from Computational Models of Trauma-Induced Inflammation, Antioxidants & Redox Signaling, 23, 17, 2015. Crossref
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Vodovotz Yoram, An Gary, An Overview of the Translational Dilemma and the Need for Model-Based Precision Medicine, in Complex Systems and Computational Biology Approaches to Acute Inflammation, 2021. Crossref
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An Gary, Vodovotz Yoram, The Rationale and Implementation of Model-Based Precision Medicine for Inflammatory Diseases, in Complex Systems and Computational Biology Approaches to Acute Inflammation, 2021. Crossref
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Vodovotz Yoram, Bartels John, An Gary, In Silico Trials and Personalized Therapy for Sepsis and Trauma, in Complex Systems and Computational Biology Approaches to Acute Inflammation, 2021. Crossref
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An Gary, Cockrell Chase, Zamora Ruben, Vodovotz Yoram, Machine learning and mechanistic computational modeling of inflammation as tools for designing immunomodulatory biomaterials, in Immunomodulatory Biomaterials, 2021. Crossref
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Brown David, Namas Rami A., Almahmoud Khalid, Zaaqoq Akram, Sarkar Joydeep, Barclay Derek A., Yin Jinling, Ghuma Ali, Abboud Andrew, Constantine Gregory, Nieman Gary, Zamora Ruben, Chang Steven C., Billiar Timothy R., Vodovotz Yoram, Trauma in silico: Individual-specific mathematical models and virtual clinical populations, Science Translational Medicine, 7, 285, 2015. Crossref