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生物医学工程评论综述™
SJR: 0.207 SNIP: 0.376 CiteScore™: 0.79

ISSN 打印: 0278-940X
ISSN 在线: 1943-619X

生物医学工程评论综述™

DOI: 10.1615/CritRevBiomedEng.v39.i2.30
pages 125-180

Biomaterial Design Considerations for Repairing the Injured Spinal Cord

Ryan J. Gilbert
Regeneration and Repair Laboratory, Department of Biomedical Engineering, Michigan Technological University, Houghton, MI; Department of Biomedical Engineering, Rensselaer Polytechnic Institute, Troy, NY
Christopher J. Rivet
Regeneration and Repair Laboratory, Department of Biomedical Engineering, Michigan Technological University, Houghton, MI; Department of Biomedical Engineering, Rensselaer Polytechnic Institute, Troy, NY
Jonathan M. Zuidema
Regeneration and Repair Laboratory, Department of Biomedical Engineering, Michigan Technological University, Houghton, MI; Department of Biomedical Engineering, Rensselaer Polytechnic Institute, Troy, NY
Phillip G. Popovich
Department of Neuroscience and The Center for Brain and Spinal Cord Repair, The Ohio State University College of Medicine, Columbus, OH

ABSTRACT

With increasing regularity, biomaterials are being designed with the goal of promoting repair of the injured spinal cord. Most often, the efficacy of novel biomaterials is tested using in vitro models; however, their true potential will be realized only after they are applied and evaluated in standardized in vivo spinal cord injury (SCI) models. The purpose of this review is to (1) provide a primer on SCI research including an overview of common pathogenic mechanisms that may respond to biomaterials and the in vivo models and outcomes assessment tools used to evaluate therapeutic efficacy; (2) review the types of biomaterials that have been tested in these models; (3) discuss which biomaterials might be applied to these models in the future; and (4) recommend future engineering strategies to create better in vivo models and assessment tools.


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