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生物医学工程评论综述™

每年出版 6 

ISSN 打印: 0278-940X

ISSN 在线: 1943-619X

SJR: 0.262 SNIP: 0.372 CiteScore™:: 2.2 H-Index: 56

Indexed in

Tissue Engineering Approaches to Heart Repair

卷 42, 册 3-4, 2014, pp. 213-227
DOI: 10.1615/CritRevBiomedEng.2014011661
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摘要

The heart is a large organ containing many cell types, each of which is necessary for normal function. Because of this, cardiac regenerative medicine presents many unique challenges. Because each of the many types of cells within the heart has unique physiological and electrophysiological characteristics, donor cells must be well matched to the area of the heart into which they are grafted to avoid mechanical dysfunction or arrhythmia. In addition, grafted cells must be functionally integrated into host tissue to effectively repair cardiac function. Because of its size and physiological function, the metabolic needs of the heart are considerable. Therefore grafts must contain not only cardiomyocytes but also a functional vascular network to meet their needs for oxygen and nutrition. In this article we review progress in the use of pluripotent stem cells as a source of donor cardiomyocytes and highlight current unmet needs in the field. We also examine recent tissue engineering approaches integrating cells with various engineered materials that should address some of these unmet needs.

对本文的引用
  1. Simon LaTonya R., Masters Kristyn S., Disease-Inspired Tissue Engineering: Investigation of Cardiovascular Pathologies, ACS Biomaterials Science & Engineering, 6, 5, 2020. Crossref

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