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生物医学工程评论综述™

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ISSN 打印: 0278-940X

ISSN 在线: 1943-619X

SJR: 0.262 SNIP: 0.372 CiteScore™:: 2.2 H-Index: 56

Indexed in

Biomaterials, Fibrosis, and the Use of Drug Delivery Systems in Future Antifibrotic Strategies

卷 37, 册 3, 2009, pp. 259-281
DOI: 10.1615/CritRevBiomedEng.v37.i3.20
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摘要

All biomaterials, when implanted into the body, elicit an inflammatory response that evolves into fibrovascular tissue formation on and around the material. As a result, material scientists and tissue engineers should be concerned about host response to tissue-engineered constructs that have a biomaterial component, because the host response to this component will interfere with device function and reduce the lifespan of tissue engineering devices in vivo. The fibrotic response to biomaterials is not unlike pathological fibrosis of the liver, lung, kidney, and peritoneum in many ways: i) the presence of mononuclear leukocytes are common in the local environment of both pathological fibrosis and biomaterial-induced fibrosis even though cells of mesenchymal origin are responsible for laying the majority of the extracellular matrix; ii) paracrinesignaling molecules, such as transforming growth factor β1, are essential mediators of fibrosis, whether it is pathological or biomaterial induced; and iii) injury and/or the presence of foreign materials (including bacterial components, toxins, or man-made objects) are essential initiators for the development of the fibrotic response. This review discusses mechanisms and research methodology related to pathological fibrosis that is of interest to researchers focused on biomaterials. Potential research models for the study of fibrosis from the fields of biomaterials and drug delivery are also discussed, which may be of interest to scientists working on the pathology of fibrotic disease.

对本文的引用
  1. Love Ryan J., Jones Kim S., Transient inhibition of connective tissue infiltration and collagen deposition into porous poly(lactic-co-glycolic acid) discs, Journal of Biomedical Materials Research Part A, 101, 12, 2013. Crossref

  2. Love R.J., Jones K.S., Adaptive Immune Responses to Biomaterials, in Comprehensive Biomaterials, 2011. Crossref

  3. Jones Kim, Fibrotic Response to Biomaterials and all Associated Sequence of Fibrosis, in Host Response to Biomaterials, 2015. Crossref

  4. López-Dolado Elisa, González-Mayorga Ankor, Gutiérrez María Concepción, Serrano María Concepción, Immunomodulatory and angiogenic responses induced by graphene oxide scaffolds in chronic spinal hemisected rats, Biomaterials, 99, 2016. Crossref

  5. Love R.J., Jones K.S., 4.4 Adaptive Immune Responses to Biomaterials ☆, in Comprehensive Biomaterials II, 2017. Crossref

  6. Poppelaars Felix, Faria Bernardo, Gaya da Costa Mariana, Franssen Casper F. M., van Son Willem J., Berger Stefan P., Daha Mohamed R., Seelen Marc A., The Complement System in Dialysis: A Forgotten Story?, Frontiers in Immunology, 9, 2018. Crossref

  7. Kastellorizios Michail, Tipnis Namita, Burgess Diane J., Foreign Body Reaction to Subcutaneous Implants, in Immune Responses to Biosurfaces, 865, 2015. Crossref

  8. Wang Sihong, Nagrath Deepak, Liver Tissue Engineering, in Biomaterials for Tissue Engineering Applications, 2011. Crossref

  9. Noskovicova Nina, Hinz Boris, Pakshir Pardis, Implant Fibrosis and the Underappreciated Role of Myofibroblasts in the Foreign Body Reaction, Cells, 10, 7, 2021. Crossref

  10. Dorris Emma R, Russell John, Murphy Madeline, Post-intubation subglottic stenosis: aetiology at the cellular and molecular level, European Respiratory Review, 30, 159, 2021. Crossref

  11. Huang Yan, Wu Chengtie, Zhang Xiaoling, Chang Jiang, Dai Kerong, Regulation of immune response by bioactive ions released from silicate bioceramics for bone regeneration, Acta Biomaterialia, 66, 2018. Crossref

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