图书馆订阅: Guest
Begell Digital Portal Begell 数字图书馆 电子图书 期刊 参考文献及会议录 研究收集
生物医学工程评论综述™
SJR: 0.207 SNIP: 0.376 CiteScore™: 0.79

ISSN 打印: 0278-940X
ISSN 在线: 1943-619X

生物医学工程评论综述™

DOI: 10.1615/CritRevBiomedEng.v28.i12.270
pages 159-163

Development of Fiber Optic and Electrochemical pH Sensors to Monitor Brain Tissue

Sheila A. Grant
Center for Biomedical Engineering, Michigan Technological University, Houghton, Ml
Kerry Bettencourt
Lawrence Livermore National Laboratory, Livermore, CA
Peter Krulevitch
Lawrence Livermore National Laboratory, Livermore, CA
Julie Hamilton
Lawrence Livermore National Laboratory, Livermore, CA
Robert Glass
Lawrence Livermore National Laboratory, Livermore, CA

ABSTRACT

This article describes fiber optic and electrochemical pH sensors that could become part of a therapeutic arsenal to quickly and aggressively treat stroke victims as well as people who have suffered brain trauma. The fiber optic sensor design was based on the immobilization of a pH-sensitive dye, seminaphthorhodamine-1 carboxylate (SNARF-1C), onto the end of a 125-mm-diameter silica optical fiber using the sol-gel method. A miniature bench-top fluorimeter system was developed for use with the optical fiber to obtain pH measurements. The electrochemical sensor was based on sputter-coated indium oxide thin films. Linear and reproducible responses for both sensors were obtained in human blood with pH varying between 6.8 to 8.0, which encompasses the clinically relevant range. In vivo studies were also performed and results indicated that both types of sensors tracked pH with very little drift.


Articles with similar content:

A Comparison of Force Sensing for Applications in Prosthetic Haptic Feedback
Critical Reviews™ in Biomedical Engineering, Vol.47, 2019, issue 2
Jinglin Liu, Megan Wieser, Priscilla Hernandez, Jeffrey T. La Belle
PUMP-PROBE THERMOREFLECTANCE
Annual Review of Heat Transfer, Vol.16, 2013, issue 16
Aaron J. Schmidt
Skin-Layer Impedance of an Explosion-Produced Plasma Column in Free Space
Telecommunications and Radio Engineering, Vol.67, 2008, issue 8
A. O. Puzanov
Hybrid Model for Simulation of Magneto-Optical Response of Layers of Semiconductor Nano-Objects
International Journal for Multiscale Computational Engineering, Vol.8, 2010, issue 2
Oleksandr Voskoboynikov
Bioactive Anthocyanins Detected in Human Urine after Ingestion of Blackcurrant Juice
Journal of Environmental Pathology, Toxicology and Oncology, Vol.20, 2001, issue 2
Irmgard Bitsch, Michael Netzel, Gabriele Strass, Marlies Janssen, Roland Bitsch