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等离子医学
SJR: 0.278 SNIP: 0.183 CiteScore™: 0.57

ISSN 打印: 1947-5764
ISSN 在线: 1947-5772

等离子医学

DOI: 10.1615/PlasmaMed.2018026588
pages 203-215

Micro-Sized Cold Atmospheric Plasma Source for Brain and Breast Cancer Treatment

Zhitong Chen
Department of Mechanical and Aerospace Engineering, The George Washington University, Washington, DC, USA
Li Lin
Department of Pathology, The Second Affiliated Hospital of Nanjing Medical University, 121 Jiangjiayuan Rd, Nanjing 010011, China; Department of Mechanical and Aerospace Engineering, The George Washington University, Washington, DC, USA
Qinmin Zheng
Department of Civil and Environmental Engineering, The George Washington University, Washington, DC, USA
Jonathan H. Sherman
Neurological Surgery, The George Washington University, Foggy Bottom South Pavilion, 22nd Street NW, 7th Floor, Washington, DC 20037, USA
Jerome Canady
Jerome Canady Research Institute for Advanced Biological and Technological Sciences, US Medical innovation LLC, Takoma Park, MD, USA
Barry Trink
Hadassah-Hebrew University Medical Center, Israel; Jerome Canady Institute for Advance Biological and Technical Science, Plasma Medicine Life Science, Takoma Park, MD, USA; Department of Otolaryngology, School of Medicine, Johns Hopkins University, Baltimore, Maryland, USA
Michael Keidar
Department of Mechanical and Aerospace Engineering, The George Washington University, Science and Engineering Hall, 800 22nd Street, NW, Room 3550, Washington, DC 20052, USA

ABSTRACT

Micro-sized cold atmospheric plasma (µCAP) has been developed to expand the applications of CAP in cancer therapy. In this paper, µCAP devices with different nozzle lengths were applied to investigate effects on both brain (glioblastoma U87) and breast (MDA-MB-231) cancer cells. Various diagnostic techniques were employed to evaluate the parameters of µCAP devices with different lengths. Parameters included potential distribution, electron density, and optical emission spectroscopy. The generation of short- and long-lived species (such as hydroxyl radical [·OH], superoxide [O2], hydrogen peroxide [H2O2], and nitrite [NO2]) were studied. These data revealed that µCAP treatment with a 20 mm long tube has a stronger effect than that of the 60 mm tube because of the synergetic effects of reactive species and free radicals. Reactive species generated by µCAP enhanced tumor cell death that was dose-dependent and nonspecific to tumor cell type.


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