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等离子医学
SJR: 0.278 SNIP: 0.183 CiteScore™: 0.57

ISSN 打印: 1947-5764
ISSN 在线: 1947-5772

等离子医学

DOI: 10.1615/PlasmaMed.2014011882
pages 243-265

Promising Trial for Treatment of Chronic Myelogenous Leukemia Using Plasma Technology

M. M. Ahmed
Radiation Biology Department, National Center for Radiation Research and Technology, Egyptian Atomic Energy Authority, Cairo, Egypt
Gamal M. El-Aragi
Plasma Department, Nuclear Research Center, Egyptian Atomic Energy Authority, Cairo, Egypt
Abdel Monsef A. Elhadary
Biological Application Dept., Nuclear Research center, Atomic Energy Authority Cairo, Egypt
Z. S. Said
Radiation Safety Department, Nuclear & Radiological Regulatory Authority, Cairo, Egypt

ABSTRACT

This article presents a trial of the treatment of chronic-phase (CP) and accelerated-phase (AP) chronic myelogenous leukemia (CML) that is resistant or only partially responded to chemotherapy. Blood samples of 6 cases diagnosed with CML were studied and compared with a control group. The first 3 cases were AP CML resistant to imatinib and nilotinib. The other 3 partially responded to the chemotherapy and returned to CP CML. Triple blood cultures for each case were exposed to a cold, pulsed, atmospheric pressure plasma jet for different durations (40, 80, and 120 seconds). Hematological, cytogenetic, and biochemical investigations were done before and after plasma jet exposure. The results showed an increase in necrotic and apoptotic cell counts and a decrease in the number of characteristic nucleoplasmic bridges (multinucleated threadlike shape). Concentrations of transforming growth factor-β1 and arginase decreased in the CML blood samples after exposure to plasma jet.This type of nonthermal plasma can kill cancer cells and prevent the cells from dividing, especially for the 80-second duration.