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雾化与喷雾

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ISSN 打印: 1044-5110

ISSN 在线: 1936-2684

The Impact Factor measures the average number of citations received in a particular year by papers published in the journal during the two preceding years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) IF: 1.2 To calculate the five year Impact Factor, citations are counted in 2017 to the previous five years and divided by the source items published in the previous five years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) 5-Year IF: 1.8 The Immediacy Index is the average number of times an article is cited in the year it is published. The journal Immediacy Index indicates how quickly articles in a journal are cited. Immediacy Index: 0.3 The Eigenfactor score, developed by Jevin West and Carl Bergstrom at the University of Washington, is a rating of the total importance of a scientific journal. Journals are rated according to the number of incoming citations, with citations from highly ranked journals weighted to make a larger contribution to the eigenfactor than those from poorly ranked journals. Eigenfactor: 0.00095 The Journal Citation Indicator (JCI) is a single measurement of the field-normalized citation impact of journals in the Web of Science Core Collection across disciplines. The key words here are that the metric is normalized and cross-disciplinary. JCI: 0.28 SJR: 0.341 SNIP: 0.536 CiteScore™:: 1.9 H-Index: 57

Indexed in

NUMERICAL SIMULATION OF THE DISPERSION AND DEPOSITION OF A SPRAY CARRIED BY A PULSATING AIRFLOW IN A PATIENT-SPECIFIC HUMAN NASAL CAVITY

卷 27, 册 11, 2017, pp. 913-928
DOI: 10.1615/AtomizSpr.2017020782
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摘要

The present numerical study concerns the dispersion and deposition of particles in a patient-specific human nose for steady and pulsating airflow conditions. The realistic three-dimensional geometry of the nasal cavity is reconstructed from a computer tomography (CT) scan. An unsteady Eulerian–Lagrangian formulation is used to describe the airflow and the spray dispersion and deposition in the realistic human nasal airway using two-way coupling between the gas and the liquid. A large eddy simulation (LES) with the dynamic Smagorinsky sub-grid scale (SGS) model is performed to study the spray in both a steady and a pulsating airflow with inflow rates of 4.78 L/min and 7.5 L/min for the steady case and a maximum inflow rate of 7.5 L/min and a frequency of 45 Hz in case of the pulsating spray as used in commercial inhalation devices. 10,000 mono-disperse particles with the diameters of 2.4 and 10 μm are uniformly and randomly injected at the nostrils. The airflow velocity reaches maximum values in the nasal valve, in parts of the septum, and in the nasopharynx. A complex airflow is observed in the vestibule and in the nasopharynx region, which may directly affect the dispersion and deposition pattern of the spray. The results reveal that the spray tends to deposit in the nasal valve, the septum, and in the nasopharynx due to the change in the direction of the airflow in these regions. Moreover, it is found that for the pulsating inflow, the aerosols are more dispersed and penetrate deeper into both the posterior regions and the meatuses where the connections to the sinuses reside.

对本文的引用
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  2. Calmet Hadrien, Inthavong Kiao, Eguzkitza Beatriz, Lehmkuhl Oriol, Houzeaux Guillaume, Vázquez Mariano, Gutheil Eva, Nasal sprayed particle deposition in a human nasal cavity under different inhalation conditions, PLOS ONE, 14, 9, 2019. Crossref

  3. Cui Xinguang, Wu Wenwang, Ge Haiwen, Investigation of airflow field in the upper airway under unsteady respiration pattern using large eddy simulation method, Respiratory Physiology & Neurobiology, 279, 2020. Crossref

  4. Farnoud Ali, Tofighian Hesam, Baumann Ingo, Garcia Guilherme J. M., Schmid Otmar, Gutheil Eva, Rashidi Mohammad Mehdi, Large eddy simulations of airflow and particle deposition in pulsating bi-directional nasal drug delivery, Physics of Fluids, 32, 10, 2020. Crossref

  5. Ahookhosh Kaveh, Saidi Maysam, Mohammadpourfard Mousa, Aminfar Habib, Hamishehkar Hamed, Farnoud Ali, Schmid Otmar, Flow Structure and Particle Deposition Analyses for Optimization of a Pressurized Metered Dose Inhaler (pMDI) in a Model of Tracheobronchial Airway, European Journal of Pharmaceutical Sciences, 164, 2021. Crossref

  6. Farnoud Ali, Tofighian Hesam, Baumann Ingo, Martin Andrew R., Rashidi Mohammad M., Menden Micheal P., Schmid Otmar, Pulsatile Bi-Directional Aerosol Flow Affects Aerosol Delivery to the Intranasal Olfactory Region: A Patient-Specific Computational Study, Frontiers in Pharmacology, 12, 2021. Crossref

  7. Cui Xinguang, Ge Haiwen, Wu Wenwang, Feng Yaning, Wang Jintao, LES study of the respiratory airflow field in a whole-lung airway model considering steady respiration, Journal of the Brazilian Society of Mechanical Sciences and Engineering, 43, 3, 2021. Crossref

  8. Taheri Mohammad Hasan, Pourmehran Oveis, Sarafraz Mohammad Mohsen, Ahookhosh Keveh, Farnoud Ali, Cui Xinguang, Effect of swirling flow and particle-release pattern on drug delivery to human tracheobronchial airways, Biomechanics and Modeling in Mechanobiology, 20, 6, 2021. Crossref

  9. Tretiakow Dmitry, Tesch Krzysztof, Meyer-Szary Jarosław, Markiet Karolina, Skorek Andrzej, Three-dimensional modeling and automatic analysis of the human nasal cavity and paranasal sinuses using the computational fluid dynamics method, European Archives of Oto-Rhino-Laryngology, 278, 5, 2021. Crossref

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  11. Wang Li, Ge Haiwen, Chen Liang, Hajipour Alireza, Feng Yaning, Cui Xinguang, LES study on the impact of airway deformation on the airflow structures in the idealized mouth–throat model, Journal of the Brazilian Society of Mechanical Sciences and Engineering, 44, 1, 2022. Crossref

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