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ISSN 打印: 1044-5110

ISSN 在线: 1936-2684

The Impact Factor measures the average number of citations received in a particular year by papers published in the journal during the two preceding years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) IF: 1.2 To calculate the five year Impact Factor, citations are counted in 2017 to the previous five years and divided by the source items published in the previous five years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) 5-Year IF: 1.8 The Immediacy Index is the average number of times an article is cited in the year it is published. The journal Immediacy Index indicates how quickly articles in a journal are cited. Immediacy Index: 0.3 The Eigenfactor score, developed by Jevin West and Carl Bergstrom at the University of Washington, is a rating of the total importance of a scientific journal. Journals are rated according to the number of incoming citations, with citations from highly ranked journals weighted to make a larger contribution to the eigenfactor than those from poorly ranked journals. Eigenfactor: 0.00095 The Journal Citation Indicator (JCI) is a single measurement of the field-normalized citation impact of journals in the Web of Science Core Collection across disciplines. The key words here are that the metric is normalized and cross-disciplinary. JCI: 0.28 SJR: 0.341 SNIP: 0.536 CiteScore™:: 1.9 H-Index: 57

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MASS BALANCE OF NEBULIZED DRUG DELIVERY: RESIDUAL DRUG LEVELS AND THE EFFECTS OF AN ALTERNATIVE AIR HUMIDIFICATION METHOD

卷 18, 册 6, 2008, pp. 495-510
DOI: 10.1615/AtomizSpr.v18.i6.20
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摘要

Pulmonary drug delivery through the use of in-line nebulizers is a widespread method for delivering therapeutics to mechanically ventilated patients. However, previous studies have shown that often less than 30% of salbutamol sulfate, the generic therapeutic administered to asthmatics, ever reaches the lungs. The purpose of this study was to investigate methods through which nebulized drug delivery could be improved. The first part of these experiments involved testing three brands of nebulizers to determine if substantial differences existed between models. It was found that all three of the nebulizers performed comparably. In these nebulizers, most of the drug was recovered in the nebulizer housings, indicating that most of the therapeutic never escaped the device. When humidity was applied to the driving airflow prior to the air reaching the nebulizer in an effort to reduce evaporation effects, it was found that residual salbutamol sulfate levels in the nebulizer decreased by nearly half.

对本文的引用
  1. Naughton Piers J., Joyce Mary, Mac Giolla Eain Marc, O’Sullivan Andrew, MacLoughlin Ronan, Evaluation of Aerosol Drug Delivery Options during Adult Mechanical Ventilation in the COVID-19 Era, Pharmaceutics, 13, 10, 2021. Crossref

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