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真核基因表达评论综述™
影响因子: 2.156 5年影响因子: 2.255 SJR: 0.649 SNIP: 0.599 CiteScore™: 3

ISSN 打印: 1045-4403
ISSN 在线: 2162-6502

真核基因表达评论综述™

DOI: 10.1615/CritRevEukaryotGeneExpr.2019030483
pages 343-350

Programming hMSCs into Potential Genetic Therapy in Cancer

Nedime Serakinci
Near East University, Faculty of Medicine, Department of Medical Genetics, Near East Avenue, Nicosia 99138, Northern Cyprus; Near East University, Faculty of Arts and Sciences, Dept. of Molecular Biology and Genetics, Near East Avenue, Nicosia 99138, Northern Cyprus
Huseyin Cagsin
Near East University, Faculty of Medicine, Department of Medical Genetics, Nicosia, Turkish Republic of Northern Cyprus; Near East University, Faculty of Art and Sciences, Department of Molecular Biology and Genetics, Nicosia, Turkish Republic of Northern Cyprus

ABSTRACT

Based on their distinct characteristics, such as self-renewal and differentiation potential, human mesenchymal stem cells (hMSCs) have been proposed as a feasible tool for cancer therapy. The characteristic of hMSCs that can be used in cancer therapy is their ability to home to primary and metastatic tumor sites. Recent studies have shown that use of stem cells obtained from adult tissue may be a novel vehicle for stem cell–mediated cancer therapy with improved antitumor effects. Stem cells have been used as vehicles to deliver various agents to tumor sites in order to decrease the size of the tumor or increase the lifespan of the organism. Genetically modified MSCs have been shown to increase apoptosis and decrease growth and angiogenesis in solid tumors. In this review, we will focus on the potential of the genetically modified hMSC-based genetic therapy that is a combination of stem cell and gene therapy approaches and its potential advantages over current therapies.

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