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真核基因表达评论综述™
影响因子: 1.734 5年影响因子: 1.848 SJR: 0.627 SNIP: 0.516 CiteScore™: 1.96

ISSN 打印: 1045-4403
ISSN 在线: 2162-6502

真核基因表达评论综述™

DOI: 10.1615/CritRevEukaryotGeneExpr.2018024615
pages 311-319

Interleukin-1 Beta +3594 C/T Gene Polymorphism and Susceptibility to Sepsis: A Meta-Analysis

Wenjuan Zheng
ICU, Yiwu Central Hospital, Yiwu, Zhejiang Province, China
Jiao Wang
ICU, Yiwu Central Hospital, Yiwu, Zhejiang Province, China
Xiaoshui Si
ICU, Yiwu Central Hospital, Yiwu, Zhejiang Province, China
Mengyan Chen
ICU, Yiwu Central Hospital, Yiwu, Zhejiang Province, China

ABSTRACT

Emerging evidence has indicated that the interleukin-1B (IL-1B) +3954 C > T polymorphism may affect individual susceptibility to sepsis. However, the results of published studies are inconclusive. The aim of this meta-analysis was to elucidate the association of this polymorphism with sepsis risk. Eligible studies were identified by a search of electronic databases. Overall and subgroup analyses were performed. Odds ratio (OR) and 95% confidence interval (CI) were applied to assess the associations between the IL-1B +3954 C > T polymorphism and sepsis risk. Six case–control studies were included in this meta-analysis. The pooled analysis indicated that the IL-1B +3954 C > T polymorphism significantly decreased the risk of sepsis under the homozygote model (TT vs. CC: OR = 0.57, 95% CI:0.37–0.88). In stratified analysis, we found that the protective effect of the IL-1B +3954 C > T polymorphism on sepsis risk remained significant in the subgroup of Caucasians and for high-quality studies. In conclusion, the IL-1B +3954 C > T polymorphism is associated with decreased sepsis risk in Caucasians. Further well-designed studies with large sample sizes are required to confirm this conclusion.


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