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ISSN 打印: 1045-4403
ISSN 在线: 2162-6502

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DOI: 10.1615/CritRevEukarGeneExpr.v11.i1-3.90
26 pages

Critical Aspects of Tissue-Engineered Therapy for Bone Regeneration

Bruce Doll
Bone Tissue Engineering Center, Carnegie Mellon University, Pittsburgh, PA
Charles Sfeir
Bone Tissue Engineering Center, Carnegie Mellon University, Pittsburgh, PA
Shelly R. Winn
Department of Surgery, Oregon Health Sciences University, 3181 S.W. Sam Jackson Park Road, Portland OR 97201
John Huard
Bone Tissue Engineering Center, Carnegie Mellon University, Pittsburgh, PA
Jeffrey Hollinger
Bone Tissue Engineering Center, Carnegie Mellon University, Pittsburgh, PA

ABSTRACT

Recent advances in bone tissue engineering are established on the understanding of an engineered scaffold, the molecular milieu within the osteogenic site, and the cell(s) predisposed to an osteogenic lineage. Advances in the incorporation of a generative vehicle into a skeletal defect require temporal and spatial distribution of the scaffold, growth factor, and cell compatible with enhanced bone healing. Monitoring events culminating in osteogenesis has focused on phenotypic and intracellular indicators. Phenotypic and intracellular indicators include the presence of receptors and intracellular signals that enable cell proliferation and differentiation. Progress in the areas of scaffold design, growth factor utilization, bone cell lineage, and intracellular signaling are reviewed.


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