每年出版 6 期
ISSN 打印: 1045-4403
ISSN 在线: 2162-6502
Indexed in
Vitamin D Control of Gene Expression: Temporal and Spatial Parameters for Organization of the Regulatory Machinery
摘要
Vitamin D is a principal modulator of skeletal gene expression, thus necessitating an understanding of interfaces between the activity of this steroid hormone and regulatory cascades that are functionally linked to the regulation of skeletal genes. Physiologic responsiveness requires combinatorial control, whereas coregulatory proteins determine the specificity of biologic responsiveness to physiologic cues. It is becoming increasingly evident that regulatory complexes containing the vitamin D receptor are dynamic rather than static. Temporal and spatial modifications in the composition of these complexes provide a mechanism for integrating regulatory signals to support positive or negative control through synergism and antagonism. Compartmentalization of components of vitamin D control in nuclear microenvironments supports the integration of regulatory activities, perhaps by establishing thresholds for protein activity in time frames that are consistent with the execution of regulatory signaling.
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Zhang Ying, Hassan Mohammad Q., Li Zhao-Yong, Stein Janet L., Lian Jane B., van Wijnen Andre J., Stein Gary S., Intricate gene regulatory networks of helix-loop-helix (HLH) proteins support regulation of bone-tissue related genes during osteoblast differentiation, Journal of Cellular Biochemistry, 105, 2, 2008. Crossref
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Sarkisyan N. G., Paskhina А. I., Shageev G. Y., Melikyan S. G., The use of ultraviolet radiation in medical practice, Clinical Medicine (Russian Journal), 100, 6, 2022. Crossref
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Lian Jane B., Stein Gary S., Montecino Martin, Stein Janet L., van Wijnen Andre J., Genetic and Epigenetic Control of the Regulatory Machinery for Skeletal Development and Bone Formation: Contributions of Vitamin D3, in Vitamin D, 2011. Crossref