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ISSN 打印: 1045-4403

ISSN 在线: 2162-6502

The Impact Factor measures the average number of citations received in a particular year by papers published in the journal during the two preceding years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) IF: 1.6 To calculate the five year Impact Factor, citations are counted in 2017 to the previous five years and divided by the source items published in the previous five years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) 5-Year IF: 2.2 The Immediacy Index is the average number of times an article is cited in the year it is published. The journal Immediacy Index indicates how quickly articles in a journal are cited. Immediacy Index: 0.3 The Eigenfactor score, developed by Jevin West and Carl Bergstrom at the University of Washington, is a rating of the total importance of a scientific journal. Journals are rated according to the number of incoming citations, with citations from highly ranked journals weighted to make a larger contribution to the eigenfactor than those from poorly ranked journals. Eigenfactor: 0.00058 The Journal Citation Indicator (JCI) is a single measurement of the field-normalized citation impact of journals in the Web of Science Core Collection across disciplines. The key words here are that the metric is normalized and cross-disciplinary. JCI: 0.33 SJR: 0.345 SNIP: 0.46 CiteScore™:: 2.5 H-Index: 67

Indexed in

Cancer Metabolism and the Warburg Effect As Anabolic Process Outcomes of Oncogene Operation

卷 20, 册 4, 2010, pp. 325-339
DOI: 10.1615/CritRevEukarGeneExpr.v20.i4.40
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摘要

Having considered the results of early works by other authors, their assumption was developed using modern knowledge that made it possible to propose the concept of a Warburg effect mechanism in cancer metabolism. This concept accents the high prevalence of anabolic processes in cancer metabolism, taking into account oncogene operation. The explanation of the Warburg effect mechanism alone has been provided considering the mechanism of energy shift to an anabolic pathway of cancer development. On the basis of previous experiments, the concept has also detected the point of bifurcation of the pathways of anabolic and catabolic processes, which have made it possible to ascertain the consumption of acetyl-CoA for anabolic processes and the lack of acetyl-CoA for catabolic processes. Thus, the results of other authors’ experiments were explained using the proposed concept. The mechanism of surviving cancer cells (apoptosis resistance) was also explained using this concept. In addition to using the Theorell formula and the proposed concept, an explanation has also been given from the physical chemistry point of view of the mechanism of the phenomenon regarding the absence of contact inhibition of proliferating cells in malignant tumors. Thus, this made it possible to explain other cancer phenomena mechanisms, including metastasis, nonhealing ulcers, and irrepressible growth mechanisms. In addition, this concept has made it possible to also explain experimental results that early and modern authors could not explain. Lastly, the distinction between mechanisms of the Pasteur effect and the Warburg effect was explained using the proposed concept.

对本文的引用
  1. Huang Chi-Ping, Hsieh Teng-Fu, Chen Chi-Cheng, Hung Xiao-Fan, Yu Ai-Lin, Chang Chawnshang, Shyr Chih-Rong, Anabolic androgens affect the competitive interactions in cell migration and adhesion between normal mouse urothelial cells and urothelial carcinoma cells, Biochemical and Biophysical Research Communications, 452, 3, 2014. Crossref

  2. Jung Dawoon E., Kim Jeong Mi, Kim Chanyang, Song Si Young, Embigin is overexpressed in pancreatic ductal adenocarcinoma and regulates cell motility through epithelial to mesenchymal transition via the TGF-β pathway, Molecular Carcinogenesis, 55, 5, 2016. Crossref

  3. Gao Shan, Tu Dan-Na, Li Heng, Jiang Jian-Xin, Cao Xin, You Jin-Bin, Zhou Xiao-Qin, Pharmacological or genetic inhibition of LDHA reverses tumor progression of pediatric osteosarcoma, Biomedicine & Pharmacotherapy, 81, 2016. Crossref

  4. Su Mei-An, Huang Yun-Tzu, Chen I-Tung, Lee Der-Yen, Hsieh Yun-Chieh, Li Chun-Yuan, Ng Tze Hann, Liang Suh-Yuen, Lin Shu-Yu, Huang Shiao-Wei, Chiang Yi-An, Yu Hon-Tsen, Khoo Kay-Hooi, Chang Geen-Dong, Lo Chu-Fang, Wang Han-Ching, Lagunoff Michael, An Invertebrate Warburg Effect: A Shrimp Virus Achieves Successful Replication by Altering the Host Metabolome via the PI3K-Akt-mTOR Pathway, PLoS Pathogens, 10, 6, 2014. Crossref

  5. M.R Ponizovskiy, Stoleski Sasho, SARS-CoV-2 affected cells Pathogeny and Therapy, International Journal of Coronaviruses, 2, 1, 2020. Crossref

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