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真核基因表达评论综述™
影响因子: 2.156 5年影响因子: 2.255 SJR: 0.649 SNIP: 0.599 CiteScore™: 3

ISSN 打印: 1045-4403
ISSN 在线: 2162-6502

真核基因表达评论综述™

DOI: 10.1615/CritRevEukarGeneExpr.v9.i2.30
pages 159-173

Multipotential Cells in the Bone Marrow Stroma: Regulation in the Context of Organ Physiology

Paolo Bianco
Dipartimento di Medicina Sperimentale, Universita dell'Aquila
Mara Riminucci
Dipartimento di Medicina Sperimentale, Universita dell'Aquila
Sergei Kuznetsov
Craniofacial and Skeletal Diseases Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, MD
Pamela Gehron Robey
Craniofacial and Skeletal Diseases Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, MD

ABSTRACT

Multipotential (osteogenic, adipogenic, chondrogenic, and myelosupportive) cells associated with the bone marrow stroma are revealed by in vitro or in vivo differentiation assays. If considered in the context of development, growth, and adaptive changes of bone as an organ, the hierarchical organization, histophysiology, and biological significance of the so-called "stromal system" appear distinct from those predicted from the commonly used analogy with the hematopoietic system, with which the stromal system and its putative "stem" cell are usually compared. The plasticity of differentiated phenotypes and the emergence of individual lineages in a defined temporal succession throughout development and postnatal life reflect the role of the multipotential cells in the stromal system in tissue adaptation and growth, rather than in cell consumption and replacement. This makes the stromal system and its progenitors an interesting paradigm of the biology of an individual cell's flexibility in complex organisms.


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