每年出版 6 期
ISSN 打印: 1045-4403
ISSN 在线: 2162-6502
Indexed in
Vitamin D and MicroRNAs in Bone
摘要
MicroRNAs (miRNAs) are short noncoding RNAs that orchestrate complex posttranscriptional regulatory networks essential to the regulation of gene expression. Through complementarity with messenger RNA (mRNA) sequences, miRNAs act primarily to silence gene expression through either degradation or inhibited translation of target transcripts. In this way, miRNAs can act to fine-tune the transcriptional regulation of gene expression, but they may also play distinct roles in the proliferation, differentiation, and function of specific cell types. miRNA regulatory networks may be particularly important for signaling molecules such as vitamin D that exert pleiotropic effects on tissues throughout the body. The active form of vitamin D, 1,25-dihydroxyvitamin D (1,25(OH)2D) functions as a steroid hormone that, when bound to its nuclear vitamin D receptor, is able to regulate target gene expression. However, recent studies have also implicated 1,25(OH)2D in epigenetic regulation of genes most notably as a modulator of miRNA function. The current review details our understanding of vitamin D and miRNAs with specific emphasis on the implications of this interaction for biological responses to vitamin D in one of its classical target tissues, i.e., bone.
-
LaPorta Erika, Welsh JoEllen, Modeling vitamin D actions in triple negative/basal-like breast cancer, The Journal of Steroid Biochemistry and Molecular Biology, 144, 2014. Crossref
-
Zhou Rui, Chun Rene F., Lisse Thomas S., Garcia Alejandro J., Xu Jianzhong, Adams John S., Hewison Martin, Vitamin D and alternative splicing of RNA, The Journal of Steroid Biochemistry and Molecular Biology, 148, 2015. Crossref
-
Landrier Jean-François, Vitamine D : sources, métabolisme et mécanismes d’action, Cahiers de Nutrition et de Diététique, 49, 6, 2014. Crossref
-
Chun Rene F., Liu Philip T., Modlin Robert L., Adams John S., Hewison Martin, Impact of vitamin D on immune function: lessons learned from genome-wide analysis, Frontiers in Physiology, 5, 2014. Crossref
-
van der Eerden Bram C.J., MicroRNAs in the skeleton: Cell-restricted or potent intercellular communicators?, Archives of Biochemistry and Biophysics, 561, 2014. Crossref
-
Landrier Jean-François, Vitamine D : sources, métabolisme et mécanismes d’action, OCL, 21, 3, 2014. Crossref
-
Rieger Sandra, Zhao Hengguang, Martin Paige, Abe Koichiro, Lisse Thomas S., The role of nuclear hormone receptors in cutaneous wound repair, Cell Biochemistry and Function, 33, 1, 2015. Crossref
-
van de Peppel Jeroen, van Leeuwen Johannes P. T. M., Vitamin D and gene networks in human osteoblasts, Frontiers in Physiology, 5, 2014. Crossref
-
Karlic Heidrun, Thaler Roman, Gerner Christopher, Grunt Thomas, Proestling Katharina, Haider Florian, Varga Franz, Inhibition of the mevalonate pathway affects epigenetic regulation in cancer cells, Cancer Genetics, 208, 5, 2015. Crossref
-
Bouillon Roger, Vitamin D, in Endocrinology: Adult and Pediatric, 2016. Crossref
-
Cetin Idil, Topcul Mehmet, Triple Negative Breast Cancer, Asian Pacific Journal of Cancer Prevention, 15, 6, 2014. Crossref
-
Sakai A., Ito M., Tomomitsu T., Tsurukami H., Ikeda S., Fukuda F., Mizunuma H., Inoue T., Saito H., Nakamura T., Efficacy of combined treatment with alendronate (ALN) and eldecalcitol, a new active vitamin D analog, compared to that of concomitant ALN, vitamin D plus calcium treatment in Japanese patients with primary osteoporosis, Osteoporosis International, 26, 3, 2015. Crossref
-
Montecino Martin, Stein Gary, Stein Janet, Zaidi Kaleem, Aguilar Rodrigo, Multiple levels of epigenetic control for bone biology and pathology, Bone, 81, 2015. Crossref
-
Butz H., Kinga N., Racz K., Patocs A., Circulating miRNAs as biomarkers for endocrine disorders, Journal of Endocrinological Investigation, 39, 1, 2016. Crossref
-
Hassan Mohammad Q., Tye Coralee E., Stein Gary S., Lian Jane B., Non-coding RNAs: Epigenetic regulators of bone development and homeostasis, Bone, 81, 2015. Crossref
-
Landrier Jean-François, Karkeni Esma, Marcotorchino Julie, Bonnet Lauriane, Tourniaire Franck, Vitamin D modulates adipose tissue biology: possible consequences for obesity?, Proceedings of the Nutrition Society, 75, 1, 2016. Crossref
-
Lombardi Giovanni, Perego Silvia, Sansoni Veronica, Banfi Giuseppe, Circulating miRNA as fine regulators of the physiological responses to physical activity: Pre-analytical warnings for a novel class of biomarkers, Clinical Biochemistry, 49, 18, 2016. Crossref
-
Goswami Ritobrata, Kaplan Mark H, Essential vitamins for an effective T cell response, World Journal of Immunology, 6, 1, 2016. Crossref
-
Patel Parmi, Shah Jigna, Role of Vitamin D in Amyloid clearance via LRP-1 upregulation in Alzheimer’s disease: A potential therapeutic target?, Journal of Chemical Neuroanatomy, 85, 2017. Crossref
-
Butz Henriett, Patócs Attila, Technical Aspects Related to the Analysis of Circulating microRNAs, in Circulating microRNAs in Disease Diagnostics and their Potential Biological Relevance, 106, 2015. Crossref
-
Nunez Lopez Yury O., Pittas Anastassios G., Pratley Richard E., Seyhan Attila A., Circulating levels of miR-7, miR-152 and miR-192 respond to vitamin D supplementation in adults with prediabetes and correlate with improvements in glycemic control, The Journal of Nutritional Biochemistry, 49, 2017. Crossref
-
Zhao Hengguang, Pullagura Sri Ramulu N., Rieger Sandra, Lisse Thomas S., Vitamin D and MicroRNAs, in Vitamin D, 2018. Crossref
-
Teymoori-Rad Majid, Mozhgani Sayed-Hamidreza, Zarei-Ghobadi Mohadeseh, Sahraian Mohammad Ali, Nejati Ahmad, Amiri Mohammad Mehdi, Shokri Fazel, Marashi Sayed Mahdi, Integrational analysis of miRNAs data sets as a plausible missing linker between Epstein-Barr virus and vitamin D in relapsing remitting MS patients, Gene, 689, 2019. Crossref
-
Michou Laëtitia, Épigénétique des maladies osseuses, Revue du Rhumatisme, 85, 5, 2018. Crossref
-
Michou Laetitia, Epigenetics of bone diseases, Joint Bone Spine, 85, 6, 2018. Crossref
-
Furst Jessica M., Stein Emily M., Starr Jessica, Shane Elizabeth, Vitamin D and Organ Transplantation, in Vitamin D, 2018. Crossref
-
Zhou Li, Wang Julie, Li Jingren, Li Ting, Chen Yanming, June Rayford R., Zheng Song Guo, 1,25-Dihydroxyvitamin D3 Ameliorates Collagen-Induced Arthritis via Suppression of Th17 Cells Through miR-124 Mediated Inhibition of IL-6 Signaling, Frontiers in Immunology, 10, 2019. Crossref
-
Rodney Cady, Rodney Sherriann, Millis Richard M., Vitamin D and Demyelinating Diseases: Neuromyelitis Optica (NMO) and Multiple Sclerosis (MS), Autoimmune Diseases, 2020, 2020. Crossref
-
Lisse Thomas S., Vitamin D Regulation of a SOD1-to-SOD2 Antioxidative Switch to Prevent Bone Cancer, Applied Sciences, 10, 7, 2020. Crossref
-
Vishlaghi Neda, Lisse Thomas S., Dicer- and Bulge Stem Cell-Dependent MicroRNAs During Induced Anagen Hair Follicle Development, Frontiers in Cell and Developmental Biology, 8, 2020. Crossref
-
Ionova Zh. I., Sergeeva E. G., Berkovich O. A., Genetic and epigenetic factors regulating the expression and function of the vitamin D receptor in patients with coronary artery disease, Russian Journal of Cardiology, 26, 2021. Crossref
-
Crescioli Clara, The Role of Estrogens and Vitamin D in Cardiomyocyte Protection: A Female Perspective, Biomolecules, 11, 12, 2021. Crossref
-
Bravo Vázquez Luis Alberto, Moreno Becerril Mariana Yunuen, Mora Hernández Erick Octavio, León Carmona Gabriela García de, Aguirre Padilla María Emilia, Chakraborty Samik, Bandyopadhyay Anindya, Paul Sujay, The Emerging Role of MicroRNAs in Bone Diseases and Their Therapeutic Potential, Molecules, 27, 1, 2021. Crossref
-
Schneider Sandra, Biberthaler Peter, Hanschen Marc, miRNA-Detektion bei Osteoblasten, BIOspektrum, 26, 6, 2020. Crossref
-
Rendina Domenico, D′Elia Lanfranco, Abate Veronica, Rebellato Andrea, Buondonno Ilaria, Succoio Mariangela, Martinelli Fabio, Muscariello Riccardo, De Filippo Gianpaolo, D′Amelio Patrizia, Fallo Francesco, Strazzullo Pasquale, Faraonio Raffaella, Vitamin D Status, Cardiovascular Risk Profile, and miRNA-21 Levels in Hypertensive Patients: Results of the HYPODD Study, Nutrients, 14, 13, 2022. Crossref
-
Jayachandran Parvathy, Koshy Linda, Sudhakaran Perumana R., Nair Govindapillai Mohanadasan, Gangaprasad Appukuttan Nair, Nair Ananthakrishnan Jayakumaran, 1, 25-(OH)2D3 protects against ER stress and miRNA dysregulation in Mus musculus neurons, Genes & Genomics, 2022. Crossref
-
He Xing, Sun Yue, Lei Nanhang, Fan Xiaobin, Zhang Cheng, Wang Yange, Zheng Kuiyang, Zhang Dongmei, Pan Weiqing, MicroRNA-351 promotes schistosomiasis-induced hepatic fibrosis by targeting the vitamin D receptor , Proceedings of the National Academy of Sciences, 115, 1, 2018. Crossref
-
Quigley Mikayla, Rieger Sandra, Capobianco Enrico, Wang Zheng, Zhao Hengguang, Hewison Martin, Lisse Thomas S, Vitamin D Modulation of Mitochondrial Oxidative Metabolism and mTOR Enforces Stress Adaptations and Anticancer Responses , JBMR Plus, 6, 1, 2022. Crossref
-
Kanemoto Yoshiaki, Nishimura Koichi, Hayakawa Akira, Sawada Takahiro, Amano Rei, Mori Jinichi, Kurokawa Tomohiro, Murakami Yoshinori, Kato Shigeaki, A long non-coding RNA as a direct vitamin D target transcribed from the antisense strand of the human HSD17B2 locus, Bioscience Reports, 42, 5, 2022. Crossref