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ISSN 打印: 1045-4403

ISSN 在线: 2162-6502

The Impact Factor measures the average number of citations received in a particular year by papers published in the journal during the two preceding years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) IF: 1.6 To calculate the five year Impact Factor, citations are counted in 2017 to the previous five years and divided by the source items published in the previous five years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) 5-Year IF: 2.2 The Immediacy Index is the average number of times an article is cited in the year it is published. The journal Immediacy Index indicates how quickly articles in a journal are cited. Immediacy Index: 0.3 The Eigenfactor score, developed by Jevin West and Carl Bergstrom at the University of Washington, is a rating of the total importance of a scientific journal. Journals are rated according to the number of incoming citations, with citations from highly ranked journals weighted to make a larger contribution to the eigenfactor than those from poorly ranked journals. Eigenfactor: 0.00058 The Journal Citation Indicator (JCI) is a single measurement of the field-normalized citation impact of journals in the Web of Science Core Collection across disciplines. The key words here are that the metric is normalized and cross-disciplinary. JCI: 0.33 SJR: 0.345 SNIP: 0.46 CiteScore™:: 2.5 H-Index: 67

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Nmp4/CIZ Closes the Parathyroid Hormone Anabolic Window

卷 22, 册 3, 2012, pp. 205-218
DOI: 10.1615/CritRevEukarGeneExpr.v22.i3.40
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摘要

Chronic degenerative diseases are increasing with the aging U.S. population. One consequence of this phenomenon is the need for long-term osteoporosis therapies. Parathyroid hormone (PTH), the only FDA-approved treatment that adds bone to the aged skeleton, loses its potency within two years of initial treatment but the mechanism regulating its limited "anabolic window" is unknown. We have discovered that disabling the nucleocytoplasmic shuttling transcription factor nuclear matrix protein 4/cas interacting zinc finger protein (Nmp4/CIZ) in mice extends the PTH bone-forming capacity. Nmp4 was discovered during our search for nuclear matrix transcription factors that couple this hormone's impact on osteoblast cytoskeletal and nuclear organization with its anabolic capacity. CIZ was independently discovered as a protein that associates with the focal adhesion-associated mechanosensor p130Cas. The Nmp4/CIZ-knockout (KO) skeletal phenotype exhibits a modestly enhanced bone mineral density but manifests an exaggerated response to both PTH and to BMP2 and is resistant to disuse-induced bone loss. The cellular basis of the global Nmp4/CIZ-KO skeletal phenotype remains to be elucidated but may involve an expansion of the bone marrow osteoprogenitor population along with modestly enhanced osteoblast and osteoclast activities supporting anabolic bone turnover. As a shuttling Cys2His2 zinc finger protein, Nmp4/CIZ acts as a repressive transcription factor perhaps associated with epigenetic remodeling complexes, but the functional significance of its interaction with p130Cas is not known. Despite numerous remaining questions, Nmp4/CIZ provides insights into how the anabolic window is regulated, and itself may provide an adjuvant therapy target for the treatment of osteoporosis by extending PTH anabolic efficacy.

对本文的引用
  1. Yang Yan, Zhang Xue-Jun, Zhu Xian-Jun, Zhang Lei, Bao Ming-Jing, Xian Yang, Wu Ji-Chuan, Liu Li-Mei, Li Peng-Qiu, Comparison between recombinant human parathyroid hormone (1–34) and elcatonin in treatment of primary osteoporosis, Asian Pacific Journal of Tropical Medicine, 8, 1, 2015. Crossref

  2. Endo Akifumi, Tomizawa Daisuke, Aoki Yuki, Morio Tomohiro, Mizutani Shuki, Takagi Masatoshi, EWSR 1/ ELF 5 induces acute myeloid leukemia by inhibiting p53/p21 pathway , Cancer Science, 107, 12, 2016. Crossref

  3. Dave Jay R., Dewle Ankush M., Mhaske Suhas T., Phulpagar Prashant T., Mathe Vikas L., More Supriya E., Khan Ayesha A., Murthy Appala Venkata Ramana, Datar Suwarna S., Jog Ajay J., Page Megha, Tomar Geetanjali B., Hydroxyapatite nanorods loaded with parathyroid hormone (PTH) synergistically enhance the net formative effect of PTH anabolic therapy, Nanomedicine: Nanotechnology, Biology and Medicine, 15, 1, 2019. Crossref

  4. Eriksen Erik Fink, Anabolics, in The Duration and Safety of Osteoporosis Treatment, 2016. Crossref

  5. Childress Paul, Stayrook Keith R., Alvarez Marta B., Wang Zhiping, Shao Yu, Hernandez-Buquer Selene, Mack Justin K., Grese Zachary R., He Yongzheng, Horan Daniel, Pavalko Fredrick M., Warden Stuart J., Robling Alexander G., Yang Feng-Chun, Allen Matthew R., Krishnan Venkatesh, Liu Yunlong, Bidwell Joseph P., Genome-Wide Mapping and Interrogation of the Nmp4 Antianabolic Bone Axis, Molecular Endocrinology, 29, 9, 2015. Crossref

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