图书馆订阅: Guest
Begell Digital Portal Begell 数字图书馆 电子图书 期刊 参考文献及会议录 研究收集
真核基因表达评论综述™
影响因子: 1.841 5年影响因子: 1.927 SJR: 0.649 SNIP: 0.516 CiteScore™: 1.96

ISSN 打印: 1045-4403
ISSN 在线: 2162-6502

真核基因表达评论综述™

DOI: 10.1615/CritRevEukarGeneExpr.v8.i2.40
pages 169-190

Coactivation and Corepression in Transcriptional Regulation by Steroid/Nuclear Hormone Receptors

J. Don Chen
Department of Pharmacology and Molecular Toxicology, University of Massachusetts Medical School, 55 Lake Avenue North, Worcester, MA 01655-0126
Hui Li
Department of Pharmacology and Molecular Toxicology, University of Massachusetts Medical School, 55 Lake Avenue North, Worcester, MA 01655-0126

ABSTRACT

Transcriptional regulation by steroid/nuclear receptors is the central theme of hormone action that controls key aspects of cell differentiation, development, and homeostasis. The molecular mechanisms of gene activation and repression by the receptors have been investigated extensively in recent years. Particularly, several new proteins involved in this signaling pathway have been identified, cloned, and demonstrated to modulate transcription in concert with nuclear receptors. In the absence of hormone, unliganded receptors interact with a family of transcriptional corepressors, including SMRT and N-CoR, which target histone deacetylases to establish a condensed and repressed chromatin structure. Upon hormone binding, the corepressor complex is replaced by a coactivator complex, containing SRC1/TIF2/RAC3 and CBP/p300, which target histone acetyltransferases to generate a transcriptionally accessible chromatin structure. These studies initiate a new era in the history of hormone research and provide novel entry points for understanding the mechanisms of transcriptional regulation by steroid/nuclear receptors.


Articles with similar content:

Heparan Sulfate Proteoglycans: Key Players in Cartilage Biology
Critical Reviews™ in Eukaryotic Gene Expression, Vol.15, 2005, issue 1
Jacqueline T. Hecht, Mary C. Farach-Carson, Daniel D. Carson
LPS-induced Cytokine Production in Human Monocytes and Macrophages
Critical Reviews™ in Immunology, Vol.31, 2011, issue 5
Matthew J. Sweet, Sunna Hauschildt, Holger Heine, Undine Meusch, Carina Klein, Dagmar Quandt, Manuela Rossol
Energy-Dependent Chromatin Remodelers: Complex Complexes and Their Components
Critical Reviews™ in Eukaryotic Gene Expression, Vol.8, 1998, issue 3-4
Anthony N. Imbalzano
Coregulators of Estrogen Receptor Action
Critical Reviews™ in Eukaryotic Gene Expression, Vol.12, 2002, issue 1
Vincent Giguere, Gilles B. Tremblay
Parameters of LRP5 from a Structural and Molecular Perspective
Critical Reviews™ in Eukaryotic Gene Expression, Vol.15, 2005, issue 3
Mark L. Johnson, Douglas T. Summerfield